Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Isorhamnetin from Oenanthe javanica Attenuates Fibrosis in Rat Hepatic Stellate Cells via Inhibition of ERK Signaling Pathway

  • Lee, Mi-Kyeong (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Yang, Hye-Kyung (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Ha, Na-Ry (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Sung, Sang-Hyun (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Kim, Young-Choong (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University)
  • Published : 2008.06.30
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Abstract

Isorhamnetin isolated from Oenanthe javanica significantly inhibited proliferation and collagen production in HSC-T6 cells in concentration- and time-dependent manners. Pretreatment of HSC-T6 cells with isorhamnetin significantly inhibited serum-induced ERK phosphorylation, in a similar manner as PD98059, a known MEK inhibitor. These results suggested that isorhamnetin reduced collagen production in HSC-T6 cells, in part, via inhibition of ERK signaling pathway.

Keywords

References

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