Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Analysis of Tandem Repeats in the Promoter Region of iNOS Gene in Korean Genome

  • Kim, Sun-Ji (Department of Biology, Keimyung University) ;
  • Yoo, Min (Department of Biology, Keimyung University)
  • ;
  • 유민 (계명대학교 생물학과)
  • Published : 2008.06.30
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Abstract

To investigate if there are tandem repeats in iNOS gene in Korean genome we applied PCR amplification followed by DNA sequencing. Tandem repeats we were looking at were (AAAT)n in the promoter region. Totally, 65 people were subjected for this experiment. Twenty of them were patients with metabolic disease. Only $(AAAT)_4$ was found in all of these Korean samples. This result was somewhat different trom the data for Caucasians and other Asian people. So, we assume this is specific VNTR (variable number of tandem repeat) in Korean which can be used for the purpose of diagnosis and for the differentiation of ethnic groups.

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