Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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Effects of the Herbal-Acupuncture with Acanthopanacis cortex extract at KI10 (Eumgok) on osteoporosis in ovariectomized DDY mice

음곡(陰谷)(KI10)에 시술한 오가피(五加皮) 약침(藥鍼)이 난소적출 생쥐의 골다공증(骨多孔症)에 미치는 영향

  • Yim, Yun-Kyoung (Dept. of Oriental Medicine Graduate school, Daejeon University) ;
  • Jeong, Yen-Tag (Dept. of Oriental Medicine Graduate school, Daejeon University)
  • 임윤경 (대전대학교 한의과대학 경락경혈학교실) ;
  • 정연탁 (대전대학교 한의과대학 경락경혈학교실)
  • Published : 2008.03.27
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Abstract

Objective : The purpose of this study is to observe the effects of herbal-acupuncture with Acanthopanacis cortex extract (AC-HA) at KI10 (Eumgok) on osteoporosis in ovariectomized (OVX) ddy mice. Methods : We carried out several experimental items to analyze the changes in body weight, uterine weight, uterus index, tibial length, the ash bone weight, tibial BMD, serum ALP, serum creatinine, serum osteocalcin, serum Ca, and the levels of Ca, P, Ca/P ratio in tibia, and we performed histological and histomorphological analysis as well. Results : Tibial BMD was significantly decreased by OVX, while significantly increased by AC-HA at KI10. Serum creatinine level was significantly increased by OVX, while significantly decreased by AC-HA at KI10. Serum osteocalcin level was significantly increased by OVX, while significantly decreased by AC-HA at KI10. Tibial TBV(trabecular bone volume) was significantly decreased by OVX, while significantly increased by AC-HA at KI10. AC-HA at KI10 significantly suppressed the OVX-induced increase of GPL(growth plate length) of tibia in mice. Conclusion : These results suggest that AC-HA at KI10 has a therapeutic effect on osteoporosis in OVX mice.

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