The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Effects of Lycii Fructus on the Ovariectomized Osteoporosis of Rats

구기자(枸杞子)가 난소적출(卵巢摘出) 흰쥐의 골조직대사(骨組織代謝)에 미치는 영향(影響)

  • Koo, Yong-Mo (Department of Anatomy & Institute of Oriental Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Sung-Hoon (Department of Neuroscience and Brain Disease, Graduate School of East-West Medicine, Kyung Hee University) ;
  • Kim, Eun-Young (Department of Anatomy & Institute of Oriental Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Hyun-Sam (Department of Anatomy & Institute of Oriental Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Choi, Hyeon (Hamsoa Pharmaceutical Co.) ;
  • Sohn, Young-Joo ;
  • Jung, Hyuk-Sang (Department of Anatomy & Institute of Oriental Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Sohn, Nak-Won (Department of Neuroscience and Brain Disease, Graduate School of East-West Medicine, Kyung Hee University)
  • 구용모 (경희대학교 한의과대학 해부학교실) ;
  • 김성훈 (경희대학교 동서의학대학원 신경과학 및 뇌질환전공) ;
  • 김은영 (경희대학교 한의과대학 해부학교실) ;
  • 이현삼 (경희대학교 한의과대학 해부학교실) ;
  • 최현 ((주)함소아 제약) ;
  • 손영주 (Department of Gynecology, College of Oriental Medicine, Sangji University) ;
  • 정혁상 (경희대학교 한의과대학 해부학교실) ;
  • 손낙원 (경희대학교 동서의학대학원 신경과학 및 뇌질환전공)
  • Published : 2008.07.31
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Abstract

Objectives: Osteoporosis is one of the most common metabolic bone disorders in the menopausal stage, a disease signified by decrease of bone mass. The purpose of this study was to learn how Lycii Fructus influences SD rats with osteoporosis caused by the removal of the ovaries. Methods: After the removal of the ovaries from 24 female Sprague-Dawley rats, they were divided into a normal group, a control group, and a Lycii Fructus (25mg/100g) administration group. After 8 weeks, the rats were sacrificed and their weights, albumin, AST, ALT, ALP, total-cholesterol, triglyceride, P, Ca, T4, E2, weight of a femur, ash content of the tibia, and area and thickness of trabecular bone were measured. Results: Regarding the density of ALT, ALP, and estradiol from serum, the Lycii Fructus group was significantly decreased compared to the control group, and the density of phosphorous and calcium also decreased slightly. Moreover, albumin, triglyceride, and T4 showed an increasing propensity, but AST and total-cholesterol showed a decreasing propensity, but not significant. Regarding the variation of bone, femur weight and ash content of tibia, the Lycii Fructus group was increased compared to the control group but significance wasn't shown. The Lycii Fructus group increased significantly over the control group in area and thickness of trabecular bone and osteoclast number. Conclusions: From the results of the above study, Lycii Fructus should be effective for osteoporosis treatment and prevention.

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