Advances in Traditional Medicine

  • 제8권3호
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  • Pages.222-227
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  • 2008
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Effect of Citrus aurantium var amara on weight change in mice

  • Sarker, Satyajit Dey (School of Biomedical Sciences, University of Ulster) ;
  • Habibi, Bohlol (Department of Pharmacology, Faculty of Pharmacy, Tabriz University of Medical Sciences) ;
  • Sharifi, Tohid (Department of Pharmacology, Faculty of Pharmacy, Tabriz University of Medical Sciences) ;
  • Asnaashari, Solmaz (Pharmacognosy Laboratory, Drug Applied Research Center, Tabriz University of Medical Sciences) ;
  • Nahar, Lutfun (School of Biomedical Sciences, University of Ulster) ;
  • Delazar, AndAbbas (Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences)
  • 발행 : 2008.09.30
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초록

Citrus aurantium var. amara L., commonly known as 'bitter orange' or 'sour orange', of the family Rutaceae, has traditionally been used in the treatment of various ailments, and it possesses different types of pharmacological properties. As a part of our on-going studies on the plantsfrom the Iranian flora, the extract of C. aurantium var. amara has been studied for its weight lossproperties using the mice model. While the Sep-Pak fraction, 20% methanol (MeOH) in water, of the hydro-methanolic extract of the peels of C. aurantium var. amara fruits, when injectedintraperitoneal (i.p.) at a dose of 10 mg/kg, significantly decreased the level of weight gain of the mice in comparison with control the group (P < 0.01), the Sep-Pak fraction 80% MeOH in water decreased the initial weight of mice by 0.44% in six weeks. The administration of the total extract(10 and 20 mg/kg, i.p.), and the Sep-Pak fractions, 40% and 60% MeOH in water (10 mg/kg, i.p.)did not show any significant change of weight of the test mice. Of the two active fractions, the80% MeOH in water fraction did not show any noticeable adverse effects on mice, and was therefore analysed by reversed-phase preparative high performance liquid chromatography resulting in the isolation and identification of four major components, two coumarins, meranzin hydrate (1) and bergamottin (2), and two flavonoids, xanthomicrol 5,4'-di-methyl ether (tangeritin, 3) and hymenoxin 5,7-di-methyl ether (nobiletin, 4).

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참고문헌

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피인용 문헌

  1. Vahl vol.25, pp.1, 2011, https://doi.org/10.1080/14786411003754330
  2. Antibacterial and free-radical-scavenging properties of Stachys schtschegleevii (Lamiaceae) vol.62, pp.4, 2010, https://doi.org/10.2298/ABS1004941A