Supplementation of Conjugated Linoleic Acid with γ-Oryzanol for 12 Weeks Effectively Reduces Body Fat in Healthy Overweight Korean Women

  • Kim, Jung-Hee (HK Biotech Co., Ltd.) ;
  • Kim, Ok-Hyun (Department of Nutrition, College of Natural Sciences, Seoul Women's University) ;
  • Ha, Yeong-Lae (Division of Applied Life Science, and Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Kim, Jeong-Ok (HK Biotech Co., Ltd.)
  • Published : 2008.09.30


The enhancement of the human body fat reduction of conjugated linoleic acid (CLA) with the supplementation of $\gamma$-oryzanol (OZ) was investigated on overweight Korean women (n=51, BMI> 23). Subjects were divided into 4 groups of control, CLA, glyceride form of CLA (GCLA), and CLA plus OZ (CLA-OZ). The soft-gel capsule (500 mg) was used to deliver control (500 mg olive oil), CLA (500 mg CLA), GCLA (500 mg GCLA) and CLA-OZ (500 mg CLA plus 50 mg OZ). Three capsules were taken twice a day for 12 weeks. The CLA-OZ supplementation reduced 1.35% body fat that was 0.34% enhancement against CLA supplementation. As considered subject variations, CLA-OZ reduced body fat ranged from 7.9% to -2.7%, equivalent to 5.6 kg loss to 0.7 kg gain in body fat mass, against CLA. The CLA-OZ reduced body weight and body mass index (BMI), relative to control, but the reductions by CLA-OZ were not different from those by CLA and GCLA. All biochemical markers analyzed for safty were not significantly different within or between groups and were within the normal range. The CLA-OZ supplementation significantly reduced blood pressure, as compared to the supplementation of CLA, GCLA and control. These results suggest that OZ could be a useful ingredient to mix with CLA for the reduction of human body fat.


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