Natural Product Sciences

  • 제14권3호
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  • Pages.167-170
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  • 2008
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Neuroprotective Lignans from Biota orientalis leaves

  • Yoon, Jeong-Seon (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Koo, Kyung-Ah (Biohealth Product Research Center (BPRC), Inje University) ;
  • Ma, Choong-Je (School of Bioscience and Biotechnology, Kangwon National University) ;
  • Sung, Sang-Hyun (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Kim, Young-Choong (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University)
  • 발행 : 2008.09.30
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초록

We previously reported that 90% MeOH fraction of Biota orientalis leaves (L.) ENDL. had significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells. In the present study, (-)-savinin (1), (-)-hinokinin (2), dehydroheliobuphthalmin (3) were isolated by bioactivity-guided fractionation from the 90% MeOH fraction. All three lignans had significant neuroprotective activities against glutamate-induced neurotoxicity at the concentrations ranging from 0.1 to 10.0 ${\mu}M$.

키워드

참고문헌

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