생약학회지 (Korean Journal of Pharmacognosy)

  • 제39권3호
  • /
  • Pages.218-222
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  • 2008
  • /
  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

은행엽엑스 제제의 기준 및 시험법과 규격 설정

Development of the Standard Analytical Methods for Ginkgo biloba Leaf Extract

  • 김승현 ((주)엘컴사이언스 생명과학연구소) ;
  • 김대현 ((주)엘컴사이언스 생명과학연구소) ;
  • 박진호 ((주)엘컴사이언스 생명과학연구소) ;
  • 오미현 (식품의약품안전청 생약평가부 생약제제과) ;
  • 조창희 (식품의약품안전청 생약평가부 생약제제과) ;
  • 백주현 (식품의약품안전청 생약평가부 생약제제과) ;
  • 조정희 (식품의약품안전청 생약평가부 생약제제과) ;
  • 김태범 (서울대학교 약학대학) ;
  • 이기용 (서울대학교 약학대학) ;
  • 김영중 (서울대학교 약학대학) ;
  • 성상현 (서울대학교 약학대학)
  • Kim, Seung-Hyun (Institute for LifeScience, Elcom Science Co. Ltd.) ;
  • Kim, Dae-Hyun (Institute for LifeScience, Elcom Science Co. Ltd.) ;
  • Park, Jin-Ho (Institute for LifeScience, Elcom Science Co. Ltd.) ;
  • Oh, Mi-Hyune (Department of Herbal Medicines Evaluation, Division of Herbal Medicinal Products, Korea Food & Drug Administration) ;
  • Cho, Chang-Hee (Department of Herbal Medicines Evaluation, Division of Herbal Medicinal Products, Korea Food & Drug Administration) ;
  • Baek, Ju-Hyun (Department of Herbal Medicines Evaluation, Division of Herbal Medicinal Products, Korea Food & Drug Administration) ;
  • Cho, Jung-Hee (Department of Herbal Medicines Evaluation, Division of Herbal Medicinal Products, Korea Food & Drug Administration) ;
  • Kim, Tae-Bum (College of Pharmacy, Seoul National University) ;
  • Lee, Ki-Yong (College of Pharmacy, Seoul National University) ;
  • Kim, Young-Choong (College of Pharmacy, Seoul National University) ;
  • Sung, Sang-Hyun (College of Pharmacy, Seoul National University)
  • 발행 : 2008.09.30
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초록

This study was carried out to establish standard analytical methods for Ginkgo biloba leaf extract. Ginkgo flavonoids, terpene lactones, ginkgolic acids were employed as reference compounds for analytical method. Analytical method of US Pharmacopoeia was adopted for flavonoids and terpene lactones, and a new method was developed for ginkgolic acids. Analytical methods established in this study could be applied to a reasonable and unified quality control of G. biloba leaf extract.

키워드

참고문헌

  1. Chung, H. S., Harris, A., Kristinsson, J. K., Ciulla, T. A., Kagemann, C. and Ritch, R. (1999) Ginkgo biloba extract increases ocular blood flow velocity. J. Ocul. Pharmacol. Ther., 15: 233-240 https://doi.org/10.1089/jop.1999.15.233
  2. Persson, J., Bringlv, E., Nilsson, L. G., and Nyberg, L. (2004) The memory-enhancing effects of Ginseng and Ginkgo biloba in healthy volunteers. Psychopharmacology, 172: 430-434 https://doi.org/10.1007/s00213-003-1675-8
  3. Dubber, M. J. and Kanfer, I. (2005) The simultaneous determination of selected flavonol glycosides and aglycones in Ginkgo biloba oral dosage forms by high-performance liquid chromatography-electrospray ionisation-mass spectrometyr. J. Pharm. Biomed. Anal., 37: 723-731 https://doi.org/10.1016/j.jpba.2004.11.052
  4. De Feudis, F.V. (1991) Ginkgo biloba Extract (EGb 761): Pharmacological activities and clinical applications. Paris, France, Elsevier
  5. Hausen, B.M. (1998) The sensitizing capacity of ginkgolic acids in guinea pigs. Am. J. Contact Dermat., 9: 146-148 https://doi.org/10.1016/S1046-199X(98)90016-1
  6. 식품의약품안전청 (2007) 대한약전외의약품등기준, 1165-1166
  7. 식품의약품안전청 (2007) 대한약전외의약품등기준(KPC) 개정에 따른 생약(한약)제제의 규격 설명회 참고자료, 30-35, 46-52
  8. The United States Pharmacopeial Convention (2007) United States Pharmacopoeia, 937-938
  9. Lichtblau, D., Berger, J. M. and Nakanishi, K. (2002) Efficient extraction of ginkgolides and biloblide from Ginkgo biloba leaves. J. Nat. Prod., 65: 1501-1504 https://doi.org/10.1021/np0201974
  10. Deng, F. and Zito, S. W. (2003) Development and validation of a gas chromatographic-mass spectrometric method for simultaneous identification and quantification of marker compounds including bilobalide, ginkgolides and flavonoids in Ginkgo biloba L. extract and pharmaceutical preparations. J. Chromatogr. A, 986: 121-127 https://doi.org/10.1016/S0021-9673(02)01921-0
  11. Ding, C., Chen, E., Zhou, W. and Lindsay, R. C. (2004) A Method for extraction and quantification of ginkgo terpene trilactones. Anal. Chem., 76: 4332-4336 https://doi.org/10.1021/ac049809a
  12. Mustafa, O., Brendan, M. and Pei, C. (2007) Comparison of the terpene lactones and flavonoids contents in G. Biloba commercial samples and the NIST standard reference materials using LC/UV/MS. J. Food Drug Anal., 15: 55-62
  13. Mesbah, M.K., Khalifa, S. I., El-Gindy, A and Tawfik, K.A. (2005) HPLC determination of certain flavonoids and terpene lactones in selected Ginkgo biloba L. phytopharmaceuticals. Farmaco., 60: 583-590 https://doi.org/10.1016/j.farmac.2005.01.014
  14. Fuzzati, N., Pace, R. and Villa, F. (2003) A simple HPLC-UV method for the assay of ginkgolic acids in Ginkgo biloba extracts. Fitoterapia, 74: 247-256 https://doi.org/10.1016/S0367-326X(03)00040-6
  15. Zhang, X., Ouyang, Z., Yang, K., Chen, J. (2003) Isolation and HPLC analysis of ginkgolic acid. Zhong Yao Cai, 26: 557-559
  16. Van Beek, T. A. and Wintermans, M. S. (2001) Preparative isolation and dual column high-performance liquid chromatography of ginkgolic acids from Ginkgo biloba. J. Chromatogr. A, 930: 109-117 https://doi.org/10.1016/S0021-9673(01)01194-3