Journal of Ginseng Research

  • 제32권3호
  • /
  • Pages.264-269
  • /
  • 2008
  • /
  • 1226-8453(pISSN)
  • /
  • 2093-4947(eISSN)
고려인삼학회 (The Korean Society of Ginseng)
권호 표지
DOI QR코드

DOI QR Code

Ginsenoside Rg3 및 그 유도체 Ginsenoside Rg3-2H의 NO 생성 및 lymphocyte 분열 억제 효과

Inhibitory Effect of Ginsenoside Rg3 and its derivative Ginsenoside Rg3-2H on NO production and lymphocyte proliferation

  • 조재열 (강원대학교 BT 특성화 학부대학 생명공학부)
  • Cho, Jae-Youl (School of Bioscience and Biotechnology, and Institute of Bioscience and Biotechnology, Kangwon National University)
  • 발행 : 2008.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Ginsenosides are major components in Panax ginseng and known to have numerous pharmacological activities such as anti-cancer, anti-diabetes, anti-viral and anti-atherosclerosis effects. In this study, the regulatory activities of G-Rg3 and its derivative 25-hydroxy Rg3 (G-Rg3-2H) on the production of nitric oxide (NO) in macrophages and the proliferation of lymphocytes prepared from spleen and bone marrow under treatment of lipopolysaccharide (LPS) or concanavalin (Con) A were examined. G-Rg3 and G-Rg3-2H dose-dependently inhibited NO production from LPS-activated RAW264.7 cells and in agreement, these compounds protected RAW264.7 cells from LPS-mediated cytotoxicity. In contrast, G-Rg3-2H dose-dependently inhibited lymphocyte proliferation induced by both LPS and Con A, while there was no inhibition by G-Rg3. Therefore, our data suggest that these compounds may be applied for NO-mediated or lymphocyte-mediated immunological diseases.

키워드

참고문헌

  1. Olszewski W. L. : The lymphatic system in body homeostasis: physiological conditions. Lymphat Res Biol 1, 11-21; discussion 21-14 (2003) https://doi.org/10.1089/15396850360495655
  2. Tetley T. D. : Inflammatory cells and chronic obstructive pulmonary disease. Curr Drug Targets Inflamm Allergy 4, 607-618 (2005) https://doi.org/10.2174/156801005774912824
  3. Rice A. P. and Herrmann C. H. : Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages. Curr HIV Res 1, 395-404 (2003) https://doi.org/10.2174/1570162033485159
  4. Gillis C. N. : Panax ginseng pharmacology: a nitric oxide link? Biochem Pharmacol 54, 1-8 (1997) https://doi.org/10.1016/S0006-2952(97)00193-7
  5. Sun J. L., Hu Y. L., Wang D. Y., Zhang B. K. and Liu J. G. : Immunologic enhancement of compound Chinese herbal medicinal ingredients and their efficacy comparison with compound Chinese herbal medicines. Vaccine 24, 2343-2348 (2006) https://doi.org/10.1016/j.vaccine.2005.11.053
  6. Rivera E., Ekholm Pettersson F., Inganas M., Paulie S. and Gronvik K. O. : The Rb1 fraction of ginseng elicits a balanced Th1 and Th2 immune response. Vaccine 23, 5411-5419 (2005) https://doi.org/10.1016/j.vaccine.2005.04.007
  7. Cho J. Y., Baik K. U., Jung J. H. and Park M. H. : In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. Eur J Pharmacol 398, 399-407 (2000) https://doi.org/10.1016/S0014-2999(00)00337-X
  8. Kim B. H. and Cho J. Y. : Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol Sin 29, 113-122 (2008) https://doi.org/10.1111/j.1745-7254.2008.00725.x
  9. Palmer R. M. and Eveson J. W. : Chronic sialadenitis. An immunocytochemical study in humans. Virchows Arch A Pathol Anat Histopathol 412, 73-78 (1987) https://doi.org/10.1007/BF00750733
  10. Szabo C. and Ohshima H. : DNA damage induced by peroxynitrite: subsequent biological effects. Nitric Oxide 1, 373-385 (1997) https://doi.org/10.1006/niox.1997.0143
  11. Cho J. Y., Yoo E. S., Baik K. U., Park M. H. and Han B. H. : In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists. Planta Med 67, 213-218 (2001) https://doi.org/10.1055/s-2001-12005
  12. Campbell J. D. and HayGlass K. T. : T cell chemokine receptor expression in human Th1- and Th2-associated diseases. Arch Immunol Ther Exp (Warsz) 48, 451-456 (2000)
  13. Cho J. Y., Kim A. R., Yoo E. S., Baik K. U. and Park M. H. : Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation. Planta Med 68, 497-500 (2002) https://doi.org/10.1055/s-2002-32556
  14. Sternberg E. M. : Neuroendocrine regulation of autoimmune/inflammatory disease. J Endocrinol 169, 429-435 (2001) https://doi.org/10.1677/joe.0.1690429

피인용 문헌

  1. The human rhinovirus: human-pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery vol.31, pp.1, 2010, https://doi.org/10.1002/med.20176