Anti-inflammatory Activity of Dandelion in Mice

급성염증유발 동물모델에서 포공영(蒲公英)의 염증억제 효과

  • Hahm, Dae-Hyun (Acupuncture & Meridian Science Research Center, Kyung-Hee University) ;
  • Sur, Bong-Jun (Acupuncture & Meridian Science Research Center, The Graduate School of East-West Medicine, Kyung-Hee University) ;
  • Han, Dong-Oh (Acupuncture & Meridian Science Research Center, Kyung-Hee University) ;
  • Park, Jae-Hyun (Graduate School of Oriental Medicine, Kyung-Hee University) ;
  • Jung, Eun-Tack (Graduate School of Oriental Medicine, Kyung-Hee University) ;
  • Lee, Hye-Jung (Acupuncture & Meridian Science Research Center, The Graduate School of East-West Medicine, Kyung-Hee University) ;
  • Koh, Yoon-Jeoung (Korea Food Research Institute) ;
  • Choi, Hee-Don (Korea Food Research Institute)
  • 함대현 (경희대학교 침구경락과학연구센터) ;
  • 서봉준 (경희대학교 침구경락과학연구센터, 한의대 기초한의과학과) ;
  • 한동오 (경희대학교 침구경락과학연구센터) ;
  • 박재현 (경희대학교 동서의학대학원) ;
  • 정은택 (경희대학교 동서의학대학원) ;
  • 이혜정 (경희대학교 침구경락과학연구센터, 한의대 기초한의과학과) ;
  • 고윤정 (한국식품연구원) ;
  • 최희돈 (한국식품연구원)
  • Published : 2008.08.25


Most inflammatory disorders are usually treated using anti-inflammatory drugs including non-steroidal anti-inflammatory drugs (NSAID) and steroidal anti-inflammatory drugs (SAID). Prolonged uses of NSAIDs and SAIDs may frequently cause adverse side-effects such as nausea, vomiting, diarrhea, constipation, decreased appetite, kidney and liver failure, ulcers, and prolonged bleeding after an injury or surgery. Thus, it is necessarily required to develop a new anti-inflammatory drug with little side-effects. Dandelion (Taraxacum officinale) possesses the therapeutic abilities to eliminate body heat and toxins and to remove swelling and inflammation. In order to verify the anti-inflammatory activity of dandelion, TPA(12-O-tetra decanoylphorbol-acetate)-induced or croton oil-induced acute edema was developed in the mouse ears, and dandelion extract dissolved in acetone was applied to both sides of inflamed ears. It was found that dandelion could significantly reduce the ear swelling, compared to that of non-treated control. In the case of $20{\mu}{\ell}$ application of $100mg/m{\ell}$ dandelion solution (DA-100), its anti-inflammatory effect was comparable to that of indomethacin, a non - steroidal anti-anflammatory drug. Taken together, it could be concluded that topically applied dandelion extract exhibited its potentials as a new drug candidate with an effective anti-inflammatory activity.



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