YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Growth Inhibitory Effects of Omega-3 Unsaturated Fatty Acid against Cancer Cell Lines

Omega 3계열 불포화 지방산의 암세포주에 대한 성장 억제효과

  • Han, Du-Seok (Department of Oral Anatomy, School of Dentistry, Wonkwang University) ;
  • Choi, Hyoung-Gyu (Department of Oral Anatomy, School of Dentistry, Wonkwang University) ;
  • Kang, Jeong-Il (Department of Physical Therapy, Daebul University) ;
  • Choi, Hwa-Jung (Natural Medicines Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Baek, Seung-Hwa (Department of Herbal Resources, Professional School of Oriental Medicine, Wonkwang University)
  • 한두석 (원광대학교 치과대학 구강해부학교실) ;
  • 최형규 (원광대학교 치과대학 구강해부학교실) ;
  • 강정일 (대불대학교 물리치료학과) ;
  • 최화정 (생명공학연구원 천연의학연구센터) ;
  • 백승화 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2008.08.31
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Abstract

The inhibitory effect of omega-3 such as linolenic acid (LNA), docosahexaenoic acid (DNA) and eicosapentaenoic acid(EPA) on the growth of normal cell lines and cancer cell lines was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyItetrazolium bromide (MTT) and 2,3-bis-2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-caboxanilide (XTT) methods. LNA was found to decrease the cell viability of human oral epithelioid carcinoma cells (KB) in the MTT assay, whereas EPA appeared to inhibit the cell adhesion activity of human skin melanoma cells (SK-MEL-3) in the XTT assay analysis. DPPH radical scavenging activity was examined on LNA, DHA and EPA at the concentration of 100 ${\mu}M$, where they showed about 53% scavenging activity. These results suggest that omega-3 unsaturated fatty acid has a potential anticancer activity.

Keywords

References

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