대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제29권2호
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- Pages.500-511
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- 2008
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- 1226-9174(pISSN)
생간건비탕가삼칠근(生肝健脾湯加三七根)이 흰쥐의 간섬유화 억제에 미치는 영향
Inhibitory Effect of Saengangeonbitang-gasamchilgn on Liver Fibrosis in Rat
- Lee, Eun (Department of internal Medicine, College of Oriental Medicine, Semyung University) ;
- Kim, Young-Chul (Department of internal Medicine, College of Oriental Medicine, Kyunghee University) ;
- Ko, Heung (Department of internal Medicine, College of Oriental Medicine, Semyung University)
- 발행 : 2008.06.30
초록
The aim of this study was to investigate the inhibitory effect of Saengangeonbitang-gasamchilgn(SGGBTGSCG) on collagen production in rat hepatic stellate cells(HSC) and on the TAA-induced chronic liver injury model in rats. Methods : 1) HSCs were treated with SGGBTGSCG extract powder(50% EtOH SGGBTGSCG, dw SGGBTGSCG). After the treatment, MTT assay, BrdU assay and procollagen assay were done. In addition, gene expressions of collagen type