Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Hepatoprotective Effect of Grifola frondosa Water Extract on Carbon Tetrachloride-induced Liver Injury in Rats

  • Lee, Jong-Suk (College of Pharmacy, Yeungnam University) ;
  • Kim, Han-Sup (School of Food Technology and Food Service Industry, Yeungnam University) ;
  • Lee, Yoon-Joo (School of Food Technology and Food Service Industry, Yeungnam University) ;
  • Yong, Cheol-Soon (College of Pharmacy, Yeungnam University) ;
  • Choi, Han-Gon (College of Pharmacy, Yeungnam University) ;
  • Han, Gi-Dong (School of Food Technology and Food Service Industry, Yeungnam University) ;
  • Kim, Jung-Ae (College of Pharmacy, Yeungnam University) ;
  • Lee, Jae-Sung (School of Food Technology and Food Service Industry, Yeungnam University)
  • Published : 2008.02.29
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Abstract

The present study aimed at assessing the protective effect of water extract from fruit body of the Grifola frondosa (GFW) on carbon tetrachloride ($CCl_4$)-induced hepatotoxicity. Rats orally administered with GFW 0.5, 1.0, 2.0 g/kg for 14 days were treated with $CCl_4$ to induce hepatotoxicity. Pretreatment with GFW remarkably prevented the elevation of serum AST, ALT, ALP, LDH, $\gamma$-GTP, and liver lipid peroxides in $CCl_4$-treated rat and GFW administration in liver injured rats by $CCl_4$ showed significant (p<0.05) protection of liver as evidenced from normal serum enzymes and malondialdehyde (MDA) levels. In the ultrastructural changes, administration of $CCl_4$-induced damage of hepatocytes with vacuolation, a highly damaged endoplasmic reticulum, and degenerating nuclei. However, pre-administration with GFW preserved normal ultrastructure of hepatocytes. These results suggest that GFW had an effect to inhibit $CCl_4$-induced liver injury in rat, and that it could be used as an effective hepatoprotective agent against chemical-induced liver damage.

Keywords

References

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