Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Inhibition of Apoptosis by Elaeocarpus sylvestris in Mice Following Whole-body Exposure to Ionizing Radiation: Implications for Radioprotectors

  • Park, Eun-Jin (College of Veterinary Medicine and Applied Radiological Science Research Institute, Cheju National University) ;
  • Lee, Nam-Ho (Department of Chemistry, College of Natural Sciences, Cheju National University) ;
  • Ahn, Gin-Nae (Faculty of Marine Life Science, Cheju National University) ;
  • Baik, Jong-Seok (Department of Chemistry, College of Natural Sciences, Cheju National University) ;
  • Lee, Je-Hee (Faculty of Aquatic Life Medicine, Cheju National University) ;
  • Hwang, Kyu-Kye (College of Veterinary Medicine and Applied Radiological Science Research Institute, Cheju National University) ;
  • Park, Jae-Woo (Department of Nuclear and Energy Engineering, Cheju National University) ;
  • Jee, Young-Heun (College of Veterinary Medicine and Applied Radiological Science Research Institute, Cheju National University)
  • Published : 2008.08.31
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Abstract

Elaeocarpus sylvestris var. ellipticus (E.S.), which contains 1, 2, 3, 4, 6-penta-O-galloyl-beta-D-glucose (PGG), is reported to have the ability to scavenge oxygen radicals, thereby protecting rat neuronal cells from oxidative damage. The potential of an E.S. extract, which contains a rich PGG, to protect radiosensitive lymphocytes and intestinal crypt cells from radiation injury induced by a single whole-body irradiation (WBI) in vivo was investigated. Our results demonstrated that in immune cells, E.S. treatment decreased the percent of tail DNA, a parameter of DNA damage, compared with levels in untreated, irradiated controls. Furthermore, apoptosis was significantly decreased in lymphocytes and intestinal crypt cells of E.S.-treated mice compared with irradiated controls. These results suggest that the E.S. extract can strengthen the radioresistance of radiosensitive lymphocytes and crypt cells by preventing apoptosis. Therefore, it was concluded that E.S. extract has the radioprotective effects in vivo through an inhibition of apoptosis.

Keywords

References

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