Effects of Various Laser Wavelengths and Power Densities on the Ocular Damage in Pigmented Rats

With the widespread use of laser in medical and industrial settings, the incidence of laser injury to the ocular continues to grow among workers involved in handling lasers. The aim of this study is to compare ocular damages after irradiation with various laser wavelengths and power density. Ocular of pigmented rats was irradiated with $CO_2$ laser, 1064 nm Nd:YAG laser, and 532 nm diode laser. We observed damage of cornea, lens, and retina using slit lamp microscope and funduscopy. H&E staining of histopathology were applied to study the specimens. The higher exposure ($200mW/cm^2$, 10 sec) with $CO_2$ laser resulted in severe damage at the cornea. For the 1064 nm Nd:YAG laser, the higher exposure than $10mW/cm^2$ (10 sec) resulted in damage at the cornea and lens. Further, with the 532 nm diode laser, retinal lesions were induced when $10mW/cm^2$ (0.25 sec) was delivered to the eye. Theses results suggest that the ocular damages are different from various laser wavelength and power density.