Food Science and Preservation (한국식품저장유통학회지)

The Korean Society of Food Preservation (한국식품저장유통학회)
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Comparison of Radical Scavenging and Immunomodulatory Activities Exhibited by an Aqueous Extract of Diospyros kaki Thunb. Fruit (Persimmon)

청도반시 추출물에 의한 라디칼소거 활성과 면역조절 활성의 상호 비교

  • Heo, Jin-Chul (Department of Food Science & Technology, Kyungpook National University) ;
  • Chae, Jang-Heui (Gyeongsangbukdo Agricultural Research & Extension Services) ;
  • Lee, Sook-Hee (Gyeongsangbukdo Agricultural Research & Extension Services) ;
  • Lee, Yun-Rae (Department of Food Science & Technology, Kyungpook National University) ;
  • Moon, Kwang-Deog (Department of Food Science & Technology, Kyungpook National University) ;
  • Chung, Shin-Kyo (Department of Food Science & Technology, Kyungpook National University) ;
  • Lee, Sang-Han (Department of Food Science & Technology, Kyungpook National University)
  • Published : 2008.10.31
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Abstract

To assess the relationship between anti-oxidant and immunomodulatory activities of Diospyros kaki Thunb. fruit, we harvested persimmons on the first Friday of every month from July to October, and conducted a DPPH assay, a T-bet promoter assay, and an ELISA for IL-4 determination. Anti-oxidant activity increased as fruit weight rose. When the fruit was extracted with five different solvents, and the extracts examined for radical scavenging activity, such activity exhibited a pattern similar to that seen when anti-oxidant activity was assessed. T-bet promoter activity decreased on ripening, whereas IL-4 expression increased, as tested in a DNFB-induced animal model. Collectively, the results suggest that inflammation-inhibitory activity, valuable in treatment of some immune diseases, rises as persimmons ripen.

청도반시 추출물로부터 라디칼 소거활성, T-bet promoter 활성, IL-4 발현 활성의 상관관계를 분석하고자 7월부터 10월까지 감을 시기별로 수확하여 분자염증 활성 여부를 확인하였다. 감의 무게는 시기가 경과할수록 무거워지면서 항산화 활성에 있어서는 감이 미숙과일수록 항산화활성이 우수하였다. 4가지의 용매로 추출한 감의 항산화 활성도 유사한 양상을 보였다. T-bet promoter 활성은 추숙이 될 수록 억제되는 양상을 보였는데, 이에 반하여 IL-4의 발현 정도는 숙성함에 따라 증가하는 것을 알 수 있었다. 이로 미루어 보아 수확시기에 따라 이러한 분자염증에 관련한 일련의 활성의 억제 효과는 감이 미숙과일수록 활성이 상승하였다.

Keywords

References

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