Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Effect of Hydrogenated Lecithin on Cytotoxicity of Liposome

  • Bae, Duck-Hwan (Department of Chemistry, Chungbuk National University) ;
  • Shin, Jae-Sup (Department of Chemistry, Chungbuk National University) ;
  • Jin, Fan-Long (School of Chemical and Materials Engineering, Jilin Institute of Chemical Technology) ;
  • Shin, Gwi-Su (Jeonbuk Regional Innovation Agency, Jeonbuk Technopark) ;
  • Park, Soo-Jin (Department of Chemistry, Inha University)
  • Published : 2009.02.20
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Abstract

In this study, a hydrogenated lecithin-containing liposome was prepared using a sonicator and microfluidizer at high shear. The surface tension, particle size, turbidity, and transition temperature ($T_c$) of the liposome were investigated and compared with the commercially available standard surfactant Tween-60. The cytotoxicities were characterized using the MTT method. The surface tension of hydrogenated lecithin was found to be higher than that of Tween-60. The particle size prepared at above $T_c$ was smaller than that prepared below $T_c$. The results of the cytotoxicity experiment indicated that Lecinol 10 exhibits the highest I$C_{50}$ value, which shows its high safety in this study.

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References

  1. Knoth, A.; Scherze, I.; Muschiolik, G. Eur. J. Lipid Sci. Technol. 2005, 107, 857 https://doi.org/10.1002/ejlt.200501205
  2. Joshia, A.; Paratkarb, S. G.; Thorata, B. N. Eur. J. Lipid Sci. Technol. 2006, 108, 363 https://doi.org/10.1002/ejlt.200600016
  3. Nii, T.; Ishii, F. Colloids Surf. B Biointerf. 2005, 41, 305 https://doi.org/10.1016/j.colsurfb.2004.12.017
  4. Bunjes, H.; Koch, M. H. J. J. Control Release 2005, 107, 229 https://doi.org/10.1016/j.jconrel.2005.06.004
  5. Nieuwenhuyzen, W.; Tomás, M. C. Eur. J. Lipid Sci. Technol. 2008, 110, 472 https://doi.org/10.1002/ejlt.200800041
  6. Bernard, F. S.; List, R. L. Lecithins; American Oil Chemists' Society: New York, 1985
  7. Israelachvili, J. N.; Michell, D. J.; Ninham, B. W. J. Chem. Soc. Faraday Trans. 1 1990, 71, 326
  8. Strauss, G. J. Soc. Cosmet. Chem. 1989, 40, 51
  9. Scherze, I.; Muschiolik, G. Colloids Surf. B Biointerf. 2001, 21, 107 https://doi.org/10.1016/S0927-7765(01)00189-8
  10. Umecky, T.; Omori, S.; Kuga, T.; Funazukuri, T. Fluid Phase Equilib. 2008, 264, 18 https://doi.org/10.1016/j.fluid.2007.10.013
  11. Mirhosseini, H.; Tan, C. P.; Aghlara, A.; Hamid, N. S. A.; Yusof, S.; Chern, B. H. Carbohydrate Polym. 2008, 73, 83 https://doi.org/10.1016/j.carbpol.2007.11.002
  12. Kawaguchi, E.; Shimokawa, K.; Ishii, F. Colloids Surf. B Biointerf. 2008, 62, 130 https://doi.org/10.1016/j.colsurfb.2007.09.027
  13. Lee, Y. K.; Jin, F. L.; Park, S. J. Bull. Korean Chem. Soc. 2007, 28, 1493 https://doi.org/10.5012/bkcs.2007.28.9.1493
  14. Park, S. J.; Lee, Y. M.; Hong, S. K. Colloids Surf. B Biointerf. 2006, 47, 211 https://doi.org/10.1016/j.colsurfb.2005.12.001
  15. Cui, Z.; Qiu, F.; Sloat, B. R. Int. J. Pharm. 2006, 313, 206 https://doi.org/10.1016/j.ijpharm.2006.01.042

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