The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Anti-Inflammatory Action of the Fractions of Platycodi radix

길경(Platycodi radix) 분획물의 항염증 활성

  • 김성연 (서울여자대학교 대학원 식품과학과) ;
  • 이은방 (서울대학교 천연물과학연구소) ;
  • 정은자 (을지대학교 보건산업대학 식품과학부)
  • Published : 2009.12.31
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Abstract

The extract of Platycodi radix has long been used as an anti-inflammatory traditional medicine in Korea for the treatment of bronchitis, asthma and acute respiratory disease. In this study, the anti-inflammatory actions of the methanol extract of Platycodi radix administered via oral administration were evaluated. The results revealed that the extracts exhibited potent anti-inflammatory action. Of the hexane, chloroform, ethyl acetate, butanol and water fractions, the butanol fraction had the most potent anti-inflammatory action. Additioinally the sapogenin obtained through acid hydrolysis of the butanol fraction did not show anti-inflammatory action. These findings confirm the value of Platycodi radix as a traditional Korean medicine.

Keywords

References

  1. 강소신의학원편. 1978. 중약대사전. pp.1775-1775, 상해과학기술출판사
  2. 상해중의학원편. 1981. 중초약학. pp.426-470, 商務印書館香港分館
  3. 약품식물학연구회. 1987. 약품 식물학 각론 개정판. pp.407-410, 학원사
  4. 육창주. 1997. 생약도감. pp.507, 경원출판사
  5. 이상인. 1981. 본초학. pp.329-330, 수서원
  6. 이창복. 1982. 대한식물도감. pp.507-508, 향문사
  7. 하북성혁명위헌회위생국, 하북성혁명위헌회상업국. 1977. 하북중초약. pp.964-965, 하북인민출판사
  8. 難波恒雄著. 1980. 원색화한약도감. pp.127-128, 보육사
  9. Akiyama T, Tanaka A, Shibata S. 1972. Chemical studies on the oriental plant drug. XX. Sapogenins of the roots of Platycodon grandiflorum A. DC.(I). Isolaion of the stereo-chemistry of polygalacic acid. Chem Pharm Bull 20:1945-1952 https://doi.org/10.1248/cpb.20.1945
  10. Cheon SA, Choi BK, Jeong CS, Lee DW, Lee EB. 2000. The anti-inflammatory and analesic actions of the fraction from Pulsatilla koreana root extract. Kor J Pharm 31:174-184
  11. Forgacs P, Provost J. 1981. Olaxoside, a saponin from olax andronensis, Olax glabriflara, Olax psittacorum. Phytochem 20:1689-1990 https://doi.org/10.1016/S0031-9422(00)98556-X
  12. Hwang SW, Park MH, Shim HK, Bae MJ. 1994. Studies on the composition of lipid, amino acid and dietary fiber from functional food source: Platycodi radix, perilla seed, evening primrose seed and aloe vera. J Korean Soc Food & Nutr 23:647-653
  13. Jeong TY. 1984. Studies on the sterols in the roots of bellflower, 1: The compositions of total fatty acids and sterols in the roots of bellflower(Platycodon glaucum Nakai). Busan National Uni 10:41-52
  14. Jeong TY. 1985. Studies on the sterols in the roots of bellflower (Platycodon glaucum Nakai): Sterylester, free sterol, steryl glycoside and acylated steryl glycoside in the roots of bellflower. Busan National Uni 11:7-16
  15. Kang SS. 1996. Triterpenoide, Saponin. Seoul National Uni. Press. pp.1-3, 107-109, 223, 313
  16. Kato H, Suzuki H, Nakao K, Lee BE, Takagi K. 1973. Vasodilating effect of crude platycodin in anesthetized dogs. Folia Pharmacol Japan 23:709-714 https://doi.org/10.1254/jjp.23.709
  17. Kim KS. 1995. Effects of platycodon grandiflorats with diet-induces hyperlipidemia. J Nutr Sci Vitaminol(Tokyo) 41:485-494 https://doi.org/10.3177/jnsv.41.485
  18. Kim SM. 1993. Pharmacological studies of Torilis japonica seed. M. sc. Thesis, Sookmyung Women's Uni.
  19. Kim TJ. 1988. Pathophysiology, diagnosis and pharmacother. pp47
  20. Kubota T, Hinoh H. 1969. The structure of platycogenic acids A, B, and C, further triterpenoid constituents of Platycodon grandiflorum A. DC.. Chem Commun 190:1313-1321
  21. Ozaki Y. 1995. Studies on antiinflammatory effect of Japanese oriental medicines(kampo medicines) used to treat inflammatory diseases. Biol Pharm Bull Apr 18:559-562 https://doi.org/10.1248/bpb.18.559
  22. Park JC, Yu YB, Lee JH, Kim NJ. 1994. Studies on the chemical components and biological activities of edible plants in Korea (VI). J Korean Soc Food Nutr 23:116-119
  23. Park MH, Lee YJ, Hwang SW, Han JP, Bae MJ. 1994. Effect of Platycodi radix saponin on serum, liver and fecal lipids content in rats fed on high fat diet. J Korean Soc Food Nutr 23:568-573
  24. Rosa MD, Girard JP, Willoughby DA. 1971. Studies of the mediators of the acute inflammatory response induced in rats in differents sites by carrageenan and turpentine. J Path 104:15-21 https://doi.org/10.1002/path.1711040103
  25. Salvemini D, Wang ZQ, Wyatt PS, Bourdon DM, Marino MH, Manning PT, Currie, MG. 1996. Nitric oxide: A key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Brit J Pharmacol 118:829-838 https://doi.org/10.1111/j.1476-5381.1996.tb15475.x
  26. Seong JD, Kim HT, Kim GS, Han SI, Kwack YH. 1999. Root yield and saponin content in different soil texture of Platycodon grandiflorum A. DC. Korean J Medcinal Corp Sci 7:282-287
  27. Tada A, Kaneiwa Y, Shibata S. 1975. Studies on the saponins of the root of Platycodin grandiflorum A. DC. Isolation and the structure of platycodin-D. Chem Pharm Bull 23:2965-2978 https://doi.org/10.1248/cpb.23.2965
  28. Takagi K, Hirai T, Lee BE, Takeuchi K. 1972. Effects of crude platycodin on gastric secretion and experimental ulcerations in rats. Chem Pharm Bull 20:775-784 https://doi.org/10.1248/cpb.20.755
  29. Takagi K, Lee BE. 1972. Pharmacological studies on A. DC. I. Acute toxicity and central depressant activity of crude platycodin. Yakugaku Zasshi 92:951-960
  30. Takagi K, Lee BE. 1972. Pharmacological studies on Platycodon grandiflorum A. DC. II. Anti-inflammatory activity of crude platycodin, its activitys on isolated organs and other pharmacological activity. Yakugaku Zasshi 92:961-968
  31. Takagi K, Lee BE. 1972. Pharmacological studies on Platycodon grandiflorum A. DC. III. Activity of crude platycodin on respiratory and ciculatory system and its other pharmacological activity. Yakugaku Zasshi 92:969-973
  32. Yoo TM, Yi SY, Chung SY, Seung SA, Rheu HM, Lee EB, Yang JS. 1998. Studies on the antiinflammatory effects of natural products. J Applied Pham 6:269-275
  33. Winter CA, Risley EA, Nuss GW. 1962. Carrageenan-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med 111:544-547 https://doi.org/10.3181/00379727-111-27849
  34. Yokoyama H. 1982. Rat plasma corticosterone secretion-inducing activities of total saponin and prosapogenin methyl esters from the roots of Platycodon grandiflorum A. DC. Yakugaku zasshi 102:1191-1194