Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of the Ethanol Extract from Lycii folium Leaves on Obesity and Blood Biochemical Indices in High-fat Diet Induced Obese Rats

구기엽 에탄올 추출물이 고지방 식이 유도 비만쥐의 비만과 혈중 생화학적 지표 조절에 미치는 영향

  • Choi, Mi-Kyeong (Dept. of Food and Nutrition, Kongju National University) ;
  • Lee, Jae-Soon (Dept. of Food Science and Nutrition, Hoseo University) ;
  • Park, Won-Jong (Dept. of Food Science and Technology, Kongju National University) ;
  • Kim, Mi-Hyun (Dept. of Food and Nutrition, Kangwon National University) ;
  • Kang, Myung-Hwa (Dept. of Food Science and Nutrition, Hoseo University)
  • 최미경 (공주대학교 식품영양학과) ;
  • 이재순 (호서대학교 식품영양학과) ;
  • 박원종 (공주대학교 식품공학과) ;
  • 김미현 (강원대학교 식품영양학과) ;
  • 강명화 (호서대학교 식품영양학과)
  • Published : 2009.12.31
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Abstract

This study was conducted to investigate the effects of ethanol extract from Lycii folium (L. folium) leaves on obesity index, serum lipids, homocysteine, leptin, ghrelin, and glucose in obese rats. Sprague-Dawley rats were administrated high-fat diets to induce obesity. Then, obese rats were divided into three diet groups: a basal-diet obese group (BO group), high-fat diet obese group (FO group), and high-fat diet plus L. folium extract obese group (FLEO group). Three groups were each fed experimental diet for 8 weeks. There were no significant differences in body weight and FER among the groups. However, obesity index such as Ro？hrer index, Lee index, and T.M. index of FLEO group was significantly decreased as compared to FO group. While serum triglyceride of BO group was significantly decreased as compared to FO group, there were no significant differences in serum lipids, homocysteine, leptin, ghrelin and glucose between FLEO group and FO group. In conclusion, these results indicated that ethanol extract from L. folium leaves might be beneficial with anti-obese effect by reduction of obesity indices in obese rats.

13주 동안 고지방식이로 비만을 유도한 비만쥐에게 10% 구기엽 에탄올 추출물을 1 mL/day로 8주간 경구투여한 후비만도, 혈중 지질, homocysteine, leptin, ghrelin, glucose 농도를 분석한 결과를 요약하면 다음과 같다. 체중증가와 식이효율은 구기엽 추출물의 유의한 영향이 없었다. 그러나 비만도의 경우 일반식이 비만군의 Rohrer index와 Lee index는 FO 군과 유의한 차이가 없었고 T.M. index는 FO 군보다 유의하게 낮았다. 또한 FLEO 군은 모든 비만지수가 FO 군보다 유의하게 낮아 구기엽 추출물이 비만도를 낮추는 것으로 나타났다. 한편 BO 군의 혈중 중성지질은 FO 군보다 유의하게 낮은 반면, 구기엽 에탄올 추출물은 혈청 지질, homocysteine, leptin, ghrelin, glucose 농도에 유의한 영향을 미치지 못한 것으로 나타났다. 이상의 결과를 종합할 때 비만쥐에서 구기엽 에탄올 추출물의 섭취는 혈중 지질이 나 비만관련 생화학적 지표에는 영향을 미치지 않지만 비만도를 낮춰 비만치료 효과의 가능성을 볼 수 있었다.

Keywords

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