Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
권호 표지

Muscle Type Change and Vascularization Effect of Semen Persicae in MCAo rats

도인(桃仁)이 중대뇌동맥 폐색 유발 흰쥐의 근육형태 변화와 혈관신생에 미치는 영향

  • Kwon, Hyeok-Joon (Dept. of Oriental Rehabilitation Medicine, Ja-Seng Oriental Medicine Hospital) ;
  • Soh, Kab-Seog (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Ho-Jun (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Lee, Myeong-Jong (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung-Hee University)
  • 권혁준 (자생한방병원 한방재활의학과) ;
  • 소갑석 (동국대학교 한의과대학 한방재활의학과교실) ;
  • 김호준 (동국대학교 한의과대학 한방재활의학과교실) ;
  • 이명종 (동국대학교 한의과대학 한방재활의학과교실)
  • Received : 2008.12.18
  • Accepted : 2008.12.30
  • Published : 2009.01.13

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Abstract

Objectives : This study was performed to investigate the effects of Semen Persicae(SP) on muscle type change and vascularization effect by measuring expression of Myosin heavy chain (MHC) and Vascular endothelial growth factor (VEGF) protein in the Middle cerebral artery occlusion(MCAo) rats. Methods : The middle cerebral artery was occluded, SP extraction was administrated for 4 days. The effects of SP on muscle type change and vascularization were measured. Results : 1. VEGF protein expressions in the Semen Persicae oral administration group of MCAo group were increased compared to the control group. 2. There were no significant difference between the Semen Persicae oral administration of MCAo group and the control group in MHC isoform (Type I, Type IIa) expression change. Conclusions : The present study demonstrates the effect of Semen Persicae in the vascularizing after ischemia, but has no significant effect in musle type change and the improvement of musle atrophy.

Keywords

References

  1. 전국한의과대학심계내과학교실. 심계내과학. 서울:서원당. 1999:420-1, 505-6.
  2. Dennis, M. Nutrition after stroke. British Medical Bulletin. 2000;56(2):466-75. https://doi.org/10.1258/0007142001903102
  3. 안경주. DHEA 투여가 뇌허혈 유발 쥐의 Type I, II 근육에 미치는 효과. 서울대학교 박사학위 논문. 2002.
  4. Spencer RF, Porter JD. Structure organization of the extraocular mescle. Rev Oculomot Res. 1988;2:33-79.
  5. Porter JD, Baker RS, Ragusa RJ, et al. Extraocular mescle: Basic and clinical aspects of structure and function. Surv Olphthalmol. 1995;39:451-84. https://doi.org/10.1016/S0039-6257(05)80055-4
  6. Gera N, Tzfra C, Stela G, Zoya. Vascular endothelial growth factor (VEGF) and receptors. FASEB. 1999;13:9-22.
  7. 김재철. 저온환경이 angigenic 및 myogenic growth factor mRNA의 발현에 미치는 영향. 한국체육대학교 박사학위 논문. 2000.
  8. 許浚. 東醫寶鑑. 서울:南山堂. 1994:712-8.
  9. 강병수. 임상배합본초학. 서울:영림사. 1994:382-4.
  10. Wang N, Liu Q, Peng D, Wang L, Wang S. Experimental study on anti-thrombus effect of different extracts from Semen Persicae. Zhong Yao Cai. 2002;25(6):414-5.
  11. 장경전, 안창범, 송춘호, 송민주. 혈전증 유발 백서에 태충 중봉의 도인약침이 미치는 영향. 대한침구학회지. 1999;16(3):335-47.
  12. Fukuda T, Ito H, Mukainaka T, Tokuda H, Nishino H, Yoshida T. Anti-tumor promoting effect of glycosides from Prunus persica seeds. Biol Pharm Bull. 2003;26(2):271-3. https://doi.org/10.1248/bpb.26.271
  13. Zhang YB, Qin F, Sun HX. Immunosuppressive activity of Semen Persicae ethanol extract on specific antibody and cellular response to ovalbwnin in mice. Chem Biodivers. 2006;3(9):967-74. https://doi.org/10.1002/cbdv.200690105
  14. Xu LM, Liu P, Liu C, Hong JH, Lu G, Xue HM, Zhu JL, Hu YY. Observation on the action of extractum semen Persicae on anti-fibrosis of liver. Zhongguo Zhong Yao Za Zhi. 1994;19(8):491-4.
  15. 송미영. 桃仁의 중대뇌동맥 폐색 유발 흰쥐에서 뇌손상 억제작용 및 신경보호 효과. 동국대학교 박사학위 논문. 2008.
  16. 이정필, 김호성, 김영주, 신영오, 이장구, 오재근. 수영이 MCAo유발 후 뇌허혈 및 하지의 근 위축에 미치는 영향. 한국체육학회지. 2004;43(4):439-48.
  17. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversiblemiddle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20(1):84-91. https://doi.org/10.1161/01.STR.20.1.84
  18. Jeff B, Dale C. enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury. J. Neurosci. 2001;21(14):5272-80.
  19. 한의과대학 본초학 편찬위원회. 본초학. 서울: 영림사. 2007:462-3.
  20. Neau JP, Bogousslavsky J. Middle cerebral artery syndromes In: Cerebrovascular disease: pathophysiology, diagnosis, and management. Eds., MD., Ginsberg J Bogousslavsky. Blackwell science. Malden. 1988:997-1027.
  21. Duncan PW, Lai SM, Keighley J. Defining post-stroke recovery:implications for design and interpretation of drug trails. Neuropharmacology. 2000;39:835-41. https://doi.org/10.1016/S0028-3908(00)00003-4
  22. Ishihara A, Roy RR, Ohira Y, Ibata Y, Edgerton VR. Hypertrophy of rat plantaris muscle fibers after voluntary running with increasing loads. J Appl Physiol. 1998;8:2183-9.
  23. Hyatt JP, Roy RR, Baldwin KM, Edgerton VR. Nerve activity independent regulation of skeletal muscle atrophy: role of MyoD and myogenin in satellite cells and myonuclei. Am J Physiol Cell Physiol. 2003;285:C1161-73. https://doi.org/10.1152/ajpcell.00128.2003
  24. Finol HJ, Lewis DM, Owens R. The effects of denervation on contractile properties or rat skeletal muscle. J Physiol. 1981;319:81-92. https://doi.org/10.1113/jphysiol.1981.sp013893
  25. Choe MA, An GJ, Lee YK, Im JH, Choi-Kwon S, Heitkemper M. Effect of early low-intensity exercise on rat hind-limb muscles following acute ischemic stroke. Biol Res Nurs. 2006;7:163-74. https://doi.org/10.1177/1099800405283566
  26. Brooke MH, Kaiser KK. Muscle fiber type : how many & what kind Arch. Neurol. 1970;23:369-79. https://doi.org/10.1001/archneur.1970.00480280083010
  27. Sant'Ana Pereira JAA. Are MyHC IIX and IID the same or is there another fast myosin heavy chain expressed in rat skeletal muscle. First Annual congress Frontiers in sports Science. Book of Anstracts. 1996:712-3.
  28. Sher J, Cardasis C. Skeletal muscle fiber types in the adult mouse. Acta Neurol Scand. 1976;54:45-56. https://doi.org/10.1111/j.1600-0404.1976.tb07619.x
  29. Hacrusuka K, Umezu Y, Ogata H. Disuse atrophy of lower limbs in hemiplegic patients. Arch Phys Med Rehabil. 1997;78:13-8. https://doi.org/10.1016/S0003-9993(97)90003-4
  30. Choe MA, An GJ, Lee YK, Im JH, Choi-Kwon S, Heitkemper M. Effect of inactivity and undernutrition after acute ischemic stroke in a rat hindlimb muscle model. Nurs Res. 2004;53:283-92. https://doi.org/10.1097/00006199-200409000-00001
  31. 한상우, 류사현, 심은섭, 이동은, 박민희, 김범회, 최현, 정혁상, 손낙원, 손영주. 속단이 중풍모델 흰쥐 비복근의 근섬유위축 및 MyoD 발현에 미치는 영향. 대한본초학학회지. 2008;23(2):159-68.
  32. 이정필, 김호성, 김영주, 신영오, 이장규, 오재근. 수영이 MCAO 유발 후 뇌허혈 및 하지의 근위축에 미치는 영향. 한국체육학회지. 2004;43(4):439-47.
  33. Ferrara, N., Houck, K., Jakeman, L., & Leung, D. W. Molecular and biological preperties of the vascular endothelial growth factor family of proteins. Endor. Rev. 1992;13:18-32. https://doi.org/10.1210/edrv-13-1-18
  34. Hudlicka, O. Mechanical factors involved in growth of the heart and its blood vessels. Cell. Mol. Biol. 1994;40:143-52.
  35. Amaral SL, Papanek PE, Green AS. Angiotensin II and VEGF are involved in angiogenesis induced by short-term exercise training. Am J Physiol Heart Circ Physiol. 2001;281(3):H1163-9.
  36. Van Bruggen, N, Thibodeaux H, Palmer JT, Lee WP, Fu L, Cairns B, Tumas D, Geriai R, Williams SP, Van Lookeren Bampagne M, Ferrara N. VGEF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain. J Clinn Invest. 1999:1613-20.
  37. Brockington A, Lewis C, Wharton S, Shaw PJ. Vascular endothelial growth factor and the nervous system. Neuropathol Appl Neurobiol. 2004;30(5):427-46. https://doi.org/10.1111/j.1365-2990.2004.00600.x
  38. Sun Y, Jin K, Xie L, Childs J, Mao XO, Logvinova A, Greenberg DA. VEGF-induced neuroprotection, neurogeneisis, and angiogenesis after focal cerebral ischemia. J Clin Invest. 2003:1613-20.