Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
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The Effects of Polygonum Cuspidatum on the Skin Functions

호장근추출물이 피부질환 및 피부미용에 미치는 영향

  • Jung, Hyun-A (Dept. of Oriental Ophthalmology, Otolaryngology & Dermatology, College of Oriental Medicine, Dae-Jeon University) ;
  • Roh, Seok-Seon (Dept. of Oriental Ophthalmology, Otolaryngology & Dermatology, College of Oriental Medicine, Dae-Jeon University) ;
  • Oh, Min-Suck (Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dae-Jeon University)
  • 정현아 (대전대학교 한의과대학 한방안이비인후피부과교실) ;
  • 노석선 (대전대학교 한의과대학 한방안이비인후피부과교실) ;
  • 오민석 (대전대학교 한의과대학 한방재활의학과교실)
  • Received : 2008.12.11
  • Accepted : 2009.01.19
  • Published : 2009.01.13

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Abstract

Objectives : This study was carried out to investigate the effects of Polygonum cuspidatum extract on several skin functions including inflammation and wrinkle formation. Methods : To investigate in vitro anti-oxidant activity assay, ethanol extracts of medicinal plants tested by DPPH method. In the next experiment, to investigate anti-inflammatory test, the RAW 264.7 macrophage cells was cultured using DMEM including the 10% FBS. To study anti-allergic effect, we blended cultured Human Mast Cells(HMC-1), and then observe $TNF-{\alpha}$, IL-8 by ELISA Results : Polygonum Cuspidatum extract has the effects of anti-inflammation and anti-allergy, which may be due to its inhibitory potential on the macrophage activation. Furthermore, Polygonum Cuspidatum extract has the anti-wrinkle effects through the inhibitory potential on the collagnease, elastase and gelatinase activities. Conclusions : The above results suggest that Polygonum Cuspidatum extract could be applicable for improvement of several skin functions.

Keywords

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