Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
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Numerical Design of Double Quantum Coherence Filter for the Detection of Myo-Inositol In vivo

인체 내 myo-Inositol 검출을 위한 수치해석적 이중양자 필터 디자인

  • Lee, Yun-Jung (Lee Gil Ya Cancer and Diabetes Institute, Gachon University Medicine and Science) ;
  • Jung, Jin-Young (Lee Gil Ya Cancer and Diabetes Institute, Gachon University Medicine and Science) ;
  • Noh, Hyung-Joon (Lee Gil Ya Cancer and Diabetes Institute, Gachon University Medicine and Science) ;
  • Yu, Ung-Sik (Lee Gil Ya Cancer and Diabetes Institute, Gachon University Medicine and Science) ;
  • Kim, Hyeon-Jin (Lee Gil Ya Cancer and Diabetes Institute, Gachon University Medicine and Science)
  • 이윤정 (가천의과학대학교, 이길여암당뇨연구원) ;
  • 정진영 (가천의과학대학교, 이길여암당뇨연구원) ;
  • 노형준 (가천의과학대학교, 이길여암당뇨연구원) ;
  • 유웅식 (가천의과학대학교, 이길여암당뇨연구원) ;
  • 김현진 (가천의과학대학교, 이길여암당뇨연구원)
  • Published : 2009.12.30
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Abstract

Purpose : A numerical method of designing a multiple quantum filter (MQF) is presented for the optimum detection of myo-inositol (mI), an important brain metabolite, by using in vivo proton nuclear magnetic resonance spectroscopy ($^1$-HMRS). Materials and Methods : Starting from the characterization of the metabolite, the filter design includes the optimization of the sequence parameters such as the two echo times (TEs), the mixing time (TM), and the flip angle and offset frequency of the 3rd $90^{\circ}$ pulse which converts multiple quantum coherences (MQCs) back into single quantum coherences (SQCs). The optimized filter was then tested both in phantom and in human brains. Results : The results demonstrate that the proposed MQF can improve the signal-to-background ratio of the target metabolite by a factor of more than three by effectively suppressing the signal from the background metabolites. Conclusion : By incorporating a numerical method into the design of MQFs in $^1$-HMRS the spectral integrity of a target metabolite, in particular, with a complicated spin system can be substantially enhanced.

목적: 수치해석적인 방법을 통해 핵자기공명 분광기법에서의 다중양자 필터를 디자인하는 방법을 소개하고 이를 뇌의 중요한 대사체인 myo-inositol의 생체 내 검출에 이용하였다. 대상 및 방법 : 이를 위해 우선적으로 myo-inositol의 분광학적 성질을 조사 한 후 다중양자 필터의 echo time, mixing time 그리고 세번째 $9^{\circ}$ 펄스의 flip angle과 offset frequency같은 시퀀스 파라미터들을 최적화 하였다. 최적화된 필터는 우선적으로 실험 팬텀에서 테스트 한 후 최종적으로 인간의 두뇌에서 그 성능을 검증하였다. 결과: 실험결과를 토대로, 본 연구에서 제안하는 다중양자 필터를 사용하여 신호의 순수도가 크게 개선된 타겟 대사체의 신호를 얻을 수 있음을 알 수 있다. 결론: 수치해석적인 방법을 통하여 핵자기공명 분광기법에서의 다중양자 필터를 디자인함으로써 특히, 복잡한 스핀계를 갖는 타겟대사체의 신호의 순수도를 크게 강화할 수 있다.

Keywords

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