Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Antioxidative and Hepatoprotective Effects of Lythrum salicaria

털부처꽃의 항산화 및 간장보호활성

  • Lee, Seung-Eun (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA) ;
  • Park, Chun-Geun (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA) ;
  • Ahn, Young-Sup (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA) ;
  • Son, Yeong-Deck (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA) ;
  • Cha, Sun-Woo (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA) ;
  • Seong, Nak-Sul (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA)
  • 이승은 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 박춘근 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 안영섭 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 손영득 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 차선우 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 성낙술 (농촌진흥청 국립원예특작과학원 인삼특작부)
  • Published : 2009.02.28
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Abstract

Several parts of Lythrum salicaria were used for this study. Scavenging activities on radicals, inhibitory activity on linoleic acid peroxidation and total phenol contents of extracts from root, flower, and aerial part were evaluated. Flower and root selected from in vitro assay were subjected to in vivo assay on $CCL_4$-induced liver injury rat model for two weeks. Carbon tetrachloride intoxication on rats produced large amounts of hepatic lipid peroxidation product, thiobarbituric acid reactive substance (TBARS) compared with normal rats. Treatment with root extract of L. salicaria (LSR) showed effective inhibitory activity on lipid peroxidation product. Administration with LSR extract significantly alleviated $CCL_4$-induced increase in GPT activity which were more effective than silymarin. The results of this study suggest that root and flower of L. salicaria have antioxidant and liver protecting activities, and root part is the most effective candidate to develop a new functional material.

Keywords

References

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