Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
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Comparative efficacy of silver containing dressing materials to Staphylococcus aureus and Pseudomonas aeruginosa on infected full thickness skin wound in the rat

흰쥐의 감염된 전층피부결손에서 은 함유 드레싱제제의 Staphylococcus aureus 및 Pseudomonas aeruginosa 균주에 대한 효과의 비교

  • Lee, Jong Hoon (Department of Plastic and Reconstructive Surgery, Eulji General Hospital, College of Medicine, Eulji University) ;
  • Kim, Dong Gu (Department of Plastic and Reconstructive Surgery, Eulji General Hospital, College of Medicine, Eulji University) ;
  • Lee, Won Mi (Department of Pathology, Eulji General Hospital, College of Medicine, Eulji University) ;
  • Chae, Jeong Don (Department of Laboratory Medicine, Eulji General Hospital, College of Medicine, Eulji University)
  • 이종훈 (을지대학교 의과대학 을지병원 성형외과학 교실) ;
  • 김동규 (을지대학교 의과대학 을지병원 성형외과학 교실) ;
  • 이원미 (을지대학교 의과대학 을지병원 병리학과 교실) ;
  • 채정돈 (을지대학교 의과대학 을지병원 진단검사의학과 교실)
  • Published : 2009.07.15
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Abstract

Purpose: The purpose of this study was to compare the effect on antibacterial activities and wound healing effect of silver containing dressings with which of Betadine against Staphylococcus aureus and Pseudomonas aeruginosa. Methods: One full thickness skin defects in rats(n=72) were developed on the back and were given rise to infection with S. aureus(n=36) and P. aeruginosa(n=36). The 72 mice were divided into 6 groups : Acticoat$^{(R)}$, Aquacel$^{(R)}$-Ag, Medifoam silver$^{(R)}$, Polymen silver$^{(R)}$, Ilvadon$^{(R)}$ and Betadine(control group) dressing groups. Five silver containing dressings and Betadine were assesed on infected wound. Measurement of wound size change, bacterial colonies count and histologic findings was applied. Antibacterial activity was analyzed with bacterial restricted zone in Mueller Hinton agar. Results: On S. aureus, wound size was more decreased in all treated groups as compared with betadine, however Ilvadon$^{(R)}$ was less decreased on P. aeruginosa. In histologic findings, experimental group showed more effective findings than others on S. aureus, however on P. aeruginosa, which was showed similar. Acticoat$^{(R)}$ was best effective in wound healing against S. aureus and P. aeruginosa. The bacterial colonies count was increased in all treated groups except Acticoat$^{(R)}$ as compared with the control group on S. aureus, which was decreased in Acticoat$^{(R)}$ and Ilvadon$^{(R)}$ group on P. aeruginosa. There were not statistical differences. The restricted zone was shown in Mueller - Hinton agar of all groups except Medifoam silver$^{(R)}$ group on S. aureus, which was shown of all groups on P. aeruginosa. There were statistical differences. Conclusion: This study suggests that silver containing dressings may have not better potential than Betadine in assisting management of wounds at risk of infection on S. aureus and P. aeruginosa. However, which have better antibacterial activity on S. aureus and P. aeruginosa.

Keywords

Acknowledgement

Supported by : 범석학술장학재단

References

  1. Dang CN, Prasad YD, Boulton AJ, Jude EB: Methicillin- resistant Staphylococcus aureus in the diabetic foot clinic: a worsening problem. Diabet Med 20: 159, 2002 https://doi.org/10.1046/j.1464-5491.2003.00860.x
  2. Valencia IC, Kirsner RS, Kerdel FA: Microbiologic evaluation of skin wounds: alarming trend toward antibiotic resistance in an inpatient dermatology service during a 10-year period. J Am Acad Dermatol 50: 845, 2004 https://doi.org/10.1016/j.jaad.2003.11.064
  3. Kim JH, Park MC, Lee IJ, Park DH: The use of Vacuum- Assisted-Closure Theraphy for the Treatment of Methicillin-Resistant-Staphylococcus aureus Infected Wounds. J Korean Soc Plast Reconstr Surg 33: 632, 2006
  4. Kaech C, Elzi L, Sendi P, Frei R, Laifer G, Bassetti S, Fluckiger U: Course and outcome of Staphylococcus aureus bacteremia: a retrospective analysis of 308 episodes in a Swiss tertiary-care centre. Clin Microbiol Infect 12: 345, 2006 https://doi.org/10.1111/j.1469-0691.2005.01359.x
  5. Murray PR, Rosenthal KS, Kobayashi GS, Pfaller MA: Medical Microbiology. 4th ed., St. Louis, Mosby Inc., 2002, p 297
  6. Dunn K, Edwards-Jones V: The role of Acticoat with nanocrystalline silver in the management of burns. Burns 30 supp 1: S1, 2004 https://doi.org/10.1016/S0305-4179(04)90000-9
  7. Mooney EK, Lippitt C, Friedman J; Plastic Surgery Educational Foundation DATA Committee: Silver dressins. Plast Reconstr Surg 117: 666, 2006 https://doi.org/10.1097/01.prs.0000200786.14017.3a
  8. Ha TS, Cho YS, Kim DH, Hur J, Chun W, Kim JH, Shin HS, Kim AS, Noh SY: The clinical effectiveness of Medifoam- silver in burns. J Korean Burn Soc 10: 65, 2007
  9. Heggers J, Goodheart RE, Washington J, McCoy L, Carino E, Dang T, Edgar P, Maness C, Chinkes D: Therapeutic efficacy of three silver dressings in an infected animal model. J Burn Care Rehabil 26: 53, 2005 https://doi.org/10.1097/01.BCR.0000150298.57472.26
  10. Caruso DM, Foster KN, Blome-Eberwein SA, Twomey JA, Herndon DN, Luterman A, Silverstein P, Antimarino JR, Bauer GJ: Randomized clinical study of Hydrofiber dressing with silver or silver sulfadiazine in the management of partial-thickness burns. J Burn Care Res 27: 298, 2006 https://doi.org/10.1097/01.BCR.0000216741.21433.66
  11. Parsons D, Bowler PG, Myles V, Jones S: Silver antimicrobial dressings in wound management: a comparison of antibacterial, physical, and chemical characteristics. Wounds 17: 222, 2005
  12. Reimer K, Wichelhaus TA, Schäfer V, Rudolph P, Kramer A, Wutzler P, Ganzer D, Fleischer W: Antimicrobial effectiveness of povidone-iodine and consequences for new application areas. Dermatology 204: 114, 2002 https://doi.org/10.1159/000057738