Toxoplasmic meningoencephalitis in a stray cat in Korea

  • Kim, Ha-Young (Animal Disease Diagnostic Center, National Veterinary Research and Quarantine Service) ;
  • Bae, You-Chan (Animal Disease Diagnostic Center, National Veterinary Research and Quarantine Service) ;
  • Woo, Gye-Hyeong (Animal Disease Diagnostic Center, National Veterinary Research and Quarantine Service) ;
  • Byun, Jae-Won (Animal Disease Diagnostic Center, National Veterinary Research and Quarantine Service) ;
  • Jung, Byeong-Yeal (Animal Disease Diagnostic Center, National Veterinary Research and Quarantine Service) ;
  • Park, Jung-Won (Animal Disease Diagnostic Center, National Veterinary Research and Quarantine Service) ;
  • Chae, Hee-Sun (Research Institute of Public Health & Environment) ;
  • Choi, Jae-Yong (Korean Veterinary Medical Association) ;
  • Nakayama, Hiroyuki (Graduate School of Agricultural and Life Sciences, The University of Tokyo) ;
  • Hwang, Eui Kyung (College of Life Science and Natural Resources, Sangji University) ;
  • Joo, Yi-Seok (Animal Disease Diagnostic Center, National Veterinary Research and Quarantine Service) ;
  • Lee, O-Soo (Animal Disease Diagnostic Center, National Veterinary Research and Quarantine Service)
  • 심사 : 2009.10.06
  • 발행 : 2009.12.31

초록

A dead stray cat was necropsied for zoonotic feline disease monitoring. Grossly, there were no specific lesions. Major microscopic lesions included lymphocytic meningoencephalitis, malacia, and tissue cysts in the cerebral and cerebellar cortex. The size and shape of tissue cysts were identical to those of Apicomplexa including Toxoplasma (T.) gondii. Bradyzoites in the tissue cyst were strongly positive for T. gondii by immunohistochemistry. Electron microscopy revealed that bradyzoites within the tissue cyst were similar to the morphological features of T. gondii. Fresh tissue samples were examined by a polymerase chain reaction assay and resulted in a specific band of T. gondii only in the brain. Based on the results, this case was diagnosed as toxoplasmosis. This is the first case of toxoplasmic meningoencephalitis in a cat in Korea.

키워드

참고문헌

  1. Anfray P, Bonetti C, Fabbrini F, Magnino S, Mancianti F, Abramo F. Feline cutaneous toxoplasmosis: a case report. Vet Dermatol 2005, 16, 131-136 https://doi.org/10.1111/j.1365-3164.2005.00434.x
  2. Berm$\'{u}$dez R, Fa$\'{\i}$lde LD, Losada AP, Nieto JM, Quiroga MI. Toxoplasmosis in Bennett's wallabies (Macropus rufogriseus) in Spain. Vet Parasitol 2009, 160, 155-158 https://doi.org/10.1016/j.vetpar.2008.10.082
  3. Burns R, Williams ES, O'Toole D, Dubey JP. Toxoplasma gondii infections in captive black-footed ferrets (Mustela Nigripes), 1992-1998: clinical signs, serology, pathology, and prevention. J Wildl Dis 2003, 39, 787-797 https://doi.org/10.7589/0090-3558-39.4.787
  4. Dubey JP, Carpenter JL. Histologically confirmed clinical toxoplasmosis in cats: 100 cases (1952-1990). J Am Vet Med Assoc 1993, 203, 1556-1566
  5. Dubey JP, Lappin MR. Toxoplasmosis and neosporosis. In: Greene CE (ed.). Infectious Diseases of the Dog and Cat. 3rd ed. pp. 754-768, Saunders, Philadelphia, 2006
  6. Dubey JP, Mergl J, Gehring E, Sundar N, Velmurugan GV, Kwok OCH, Grigg ME, Su C, Martineau D. Toxoplasmosis in captive dolphins (Tursiops truncatus) and walrus (Odobenus rosmarus). J Parasitol 2009, 95, 82-85 https://doi.org/10.1645/GE-1764.1
  7. Dubey JP, Zajac A, Osofsky SA, Tobias L. Acute primary toxoplasmic hepatitis in an adult cat shedding Toxoplasma gondii oocysts. J Am Vet Med Assoc 1990, 197, 1616-1618
  8. Falzone C, Baroni M, De Lorenzi D, Mandara MT. Toxoplasma gondii brain granuloma in a cat: diagnosis using cytology from an intraoperative sample and sequential magnetic resonance imaging. J Small Anim Pract 2008, 49, 95-99 https://doi.org/10.1111/j.1748-5827.2007.00421.x
  9. Frank RK. An outbreak of toxoplasmosis in farmed mink (Mustela vison S.). J Vet Diagn Invest 2001, 13, 245-249 https://doi.org/10.1177/104063870101300310
  10. Kim HY, Kim YA, Kang S, Lee HS, Rhie HG, Ahn HJ, Nam HW, Lee SE. Prevalence of Toxoplasma gondii in Stray cats of Gyeonggi-do, Korea. Korean J Parasitol 2008, 46, 199-201 https://doi.org/10.3347/kjp.2008.46.3.199
  11. Lee JY, Lee SE, Lee EG, Song KH. Nested PCRbased detection of Toxoplasma gondii in German shepherd dogs and stray cats in South Korea. Res Vet Sci 2008, 85, 125-127 https://doi.org/10.1016/j.rvsc.2007.09.006
  12. Lindsay DS, Thomas NJ, Rosypal AC, Dubey JP. Dual Sarcocystis neurona and Toxoplasma gondii infection in a Northern sea otter from Washington state, USA. Vet Parasitol 2001, 97, 319-327 https://doi.org/10.1016/S0304-4017(01)00411-3
  13. Miller MA, Sverlow K, Crosbie PR, Barr BC, Lowenstine LJ, Gulland FM, Packham A, Conrad PA. Isolation and characterization of two parasitic protozoa from a pacific harbor seal (Phoca vitulina richardsi) with meningoencephalomyelitis. J Parasitol 2001, 87, 816-822 https://doi.org/10.1645/0022-3395(2001)087[0816:IACOTP]2.0.CO;2
  14. Park CH, Ikadai H, Yoshida E, Isomura H, Inukai H, Oyamada T. Cutaneous toxoplasmosis in a female Japanese cat. Vet Pathol 2007, 44, 683-687 https://doi.org/10.1354/vp.44-5-683
  15. Pfohl JC, Dewey CW. Intracranial Toxoplasma gondii granuloma in a cat. J Feline Med Surg 2005, 7, 369-374 https://doi.org/10.1016/j.jfms.2005.03.004
  16. Schatzberg SJ, Haley NJ, Barr SC, DeLahunta A, Olby N, Munana K, Sharp NJH. Use of a multiplex polymerase chain reaction assay in the antemortem diagnosis of toxoplasmosis and neosporosis in the central nervous system of cats and dogs. Am J Vet Res 2003, 64, 1507-1513 https://doi.org/10.2460/ajvr.2003.64.1507
  17. Song KJ, Shin JC, Shin HJ, Nam HW. Seroprevalence of toxoplasmosis in Korean pregnant women. Korean J Parasitol 2005, 43, 69-71 https://doi.org/10.3347/kjp.2005.43.2.69
  18. Speer CA, Dubey JP, McAllister MM, Blixt JA. Comparative ultrastructure of tachyzoites, bradyzoites, and tissue cysts of Neospora caninum and Toxoplasma gondii. Int J Parasitol 1999, 29, 1509-1519 https://doi.org/10.1016/S0020-7519(99)00132-0
  19. Stiles J, Prade R, Greene C. Detection of Toxoplasma gondii in feline and canine biological samples by use of the polymerase chain reaction. Am J Vet Res 1996, 57, 264-267
  20. Suh MD, Joo BH. Polymerase chain reaction for the detection of Toxoplasma gondii in the blood of cats. Korean J Vet Res 1999, 39, 1151-1160
  21. Suh MD, Shin GW. Detection of Toxoplasma gondii in experimentally infected porcine blood and tissues by polymerase chain reaction. Korea J Vet Res 2001, 41, 89-98
  22. Ward JM, Nelson N, Wright JF, Berman E. Chronic nonclinical cerebral toxoplasmosis in cats. J Am Vet Med Assoc 1971, 159, 1012-1014
  23. Williams SM, Fulton RM, Render JA, Mansfield L, Bouldin M. Ocular and encephalic toxoplasmosis in canaries. Avian Dis 2001, 45, 262-267 https://doi.org/10.2307/1593039
  24. Yang HJ, Jin KN, Park YK, Hong SC, Bae JM, Lee SH, Choi HS, Hwang HS, Chung YB, Lee NS, Nam HW. Seroprevalence of toxoplasmosis in the residents of Cheju island, Korea. Korean J Parasitol 2000, 38, 91-93 https://doi.org/10.3347/kjp.2000.38.2.91