Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Genetic analysis of canine parvovirus vaccine strains in Korea

  • Yang, Dong-Kun (National Veterinary Research and Quarantine Service) ;
  • Kim, Byoung-Han (National Veterinary Research and Quarantine Service) ;
  • Kim, Yeon-Hee (National Veterinary Research and Quarantine Service) ;
  • Lee, Kyung-Woo (National Veterinary Research and Quarantine Service) ;
  • Choi, Sung-Suk (National Veterinary Research and Quarantine Service) ;
  • Son, Seong-Wan (National Veterinary Research and Quarantine Service)
  • Accepted : 2009.08.26
  • Published : 2009.09.30
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Abstract

After the original identification of canine parvovirus (CPV) type 2 (CPV-2) in 1978, new antigenic variants such as CPV-2a, CPV-2b and CPV-2c have become widespread in the most countries. In this study, the genetic analysis of canine parvovirus was investigated in a total of 13 CPV vaccines, which have been licensed in Korea since late 1980s, and a field isolate of CPV from a dog with CPV infection clinical symptom. The partial VP2 gene of CPV was amplified and sequenced from 13 vaccine strains and one field isolate. The results showed that of the 13 vaccine strains, 10 strains belong to the CPV-2, 2 strains to CPV-2b, the remaining and one isolate to CPV-2a type, respectively. Several mutations of amino acids were detected at residues of the critical region of the commercial vaccine strains. These data suggest that new type of vaccines containing CPV-2a or CPV-2b/2c type may be required for the better prevention of new CPV infection in dog population in Korea, because CPV-2 contained in most licensed vaccines has been replaced by antigenic variants designated CPV-2a or CPV-2b/c in the worldwide dog population.

Keywords

References

  1. Appel MJ, Cooper BJ, Greisen H, Scott F, Carmichael LE. Canine viral enteritis. I. Status report on corona- and parvo-like viral enteritides. Cornell Vet 1979, 69, 123-133
  2. Battilani M, Scagliarini A, Tisato E, Turilli C, Jacoboni I, Casadio R, Prosperi S. Analysis of canine parvovirus sequences from wolves and dogs isolated in Italy. J Gen Virol 2001, 82, 1555-1560 https://doi.org/10.1099/0022-1317-82-7-1555
  3. Buonavoglia C, Martella V, Pratelli A, Tempesta M, Cavalli A, Buonavoglia D, Bozzo G, Elia G, Decaro N, Carmichael L. Evidence for evolution of canine parvovirus type 2 in Italy. J Gen Virol 2001, 82, 3021- 3025 https://doi.org/10.1099/0022-1317-82-12-3021
  4. Cotmore SF, Tattersall P. The autonomously replicating parvoviruses of vertebrates. Adv Virus Res 1987, 33, 91-174 https://doi.org/10.1016/S0065-3527(08)60317-6
  5. Decaro N, Desario C, Addie DD, Martella V, Vieira MJ, Elia G, Zicola A, Davis C, Thompson G, Thiry E, Truyen U, Buonavoglia C. The study molecular epidemiology of canine parvovirus, Europe. Emerg Infect Dis 2007, 13, 1222-1224 https://doi.org/10.3201/eid1308.070505
  6. Decaro N, Elia G, Campolo M, Desario C, Lucente MS, Bellacicco AL, Buonavoglia C. New approaches for the molecular characterization of canine parvovirus type 2 strains. J Vet Med B Infect Dis Vet Public Health 2005, 52, 316-319 https://doi.org/10.1111/j.1439-0450.2005.00869.x
  7. Greenwood NM, Chalmers WS, Baxendale W, Thompson H. Comparison of isolates of canine parvovirus by restriction enzyme analysis, and vaccine efficacy against field strains. Vet Rec 1995, 136, 63-6 https://doi.org/10.1136/vr.136.3.63
  8. Hong C, Decaro N, Desario C, Tanner P, Pardo MC, Sanchez S, Buonavoglia C, Saliki JT. Occurrence of canine parvovirus type 2c in the United States. J Vet Diagn Invest 2007, 19, 535-539 https://doi.org/10.1177/104063870701900512
  9. Ikeda Y, Mochizuki M, Naito R, Nakamura K, Miyazawa T, Mikami T, Takahashi E. Predominance of canine parvovirus (CPV) in unvaccinated cat populations and emergence of new antigenic types of CPVs in cats. Virology 2000, 278, 13-19 https://doi.org/10.1006/viro.2000.0653
  10. Kang BK, Song DS, Lee CS, Jung KI, Park SJ, Kim EM, Park BK. Prevalence and genetic characterization of canine parvoviruses in Korea. Virus Genes 2008, 36, 127-133 https://doi.org/10.1007/s11262-007-0189-6
  11. Kapil S, Cooper E, Lamm C, Murray B, Rezabek G, Johnston L 3rd, Campbell G, Johnson B. Canine parvovirus types 2c and 2b circulating in North American dogs in 2006 and 2007. J Clin Microbiol 2007, 45, 4044-4047 https://doi.org/10.1128/JCM.01300-07
  12. Kim D. Typing and pathogenicity investigation of canine parvovirus isolates from Korea. Extramural research project report NVRQS. pp. 41-69, NVRQS, Anyang, 2007
  13. Korea Animal Health Products Association. Import and Sales Amount of Animal Health Products. pp. 285- 312, Korea Animal Health Products Association, Seoul, 2008
  14. Jeoung SY, Ahn SJ, Kim D. Genetic analysis of VP2 gene of canine parvovirus isolates in Korea. J Vet Med Sci 2008, 70, 719-722 https://doi.org/10.1292/jvms.70.719
  15. Moon HS, Lee SA, Lee SG, Choi R, Jeoung SY, Kim D, Hyun C. Comparison of the pathogenicity in three different Korean canine parvovirus 2 (CPV-2) isolates. Vet Microbiol 2008, 131, 47-56 https://doi.org/10.1016/j.vetmic.2008.02.016
  16. Ohshima T, Hisaka M, Kawakami K, Kishi M, Tohya Y, Mochizuki M. Chronological analysis of canine parvovirus type 2 isolates in Japan. J Vet Med Sci 2008, 70, 769-775 https://doi.org/10.1292/jvms.70.769
  17. Parker JS, Murphy WJ, Wang D, O'Brien SJ, Parrish CR. Canine and feline parvoviruses can use human or feline transferrin receptors to bind, enter, andinfect cells. J Virol 2001, 75, 3896-3902 https://doi.org/10.1128/JVI.75.8.3896-3902.2001
  18. Parrish CR, Kawaoka Y. The origins of new pandemic viruses: the acquisition of new host ranges by canine parvovirus and influenza A viruses. Annu Rev Microbiol 2005, 59, 553-586 https://doi.org/10.1146/annurev.micro.59.030804.121059
  19. Pratelli A, Cavalli A, Martella V, Tempesta M, Decaro N, Carmichael LE, Buonavoglia C. Canine parvovirus (CPV) vaccination: comparison of neutralizing antibody responses in pups after inoculation with CPV2 or CPV2b modified live virus vaccine. Clin Diagn Lab Immunol 2001, 8, 612-615
  20. Spibey N, Greenwood NM, Sutton D, Chalmers WSK, Tarpey I. Canine parvovirus type 2 vaccine protects against virulent challenge with type 2c virus. Vet Microbiol 2008, 128, 48-55 https://doi.org/10.1016/j.vetmic.2007.09.015
  21. Truyen U. Evolution of canine parvovirus-a need for new vaccines? Vet Microbiol 2006, 117, 9-13 https://doi.org/10.1016/j.vetmic.2006.04.003
  22. Truyen U, Agbandje M, Parrish CR. Characterization of the feline host range and a specific epitope of feline panleukopenia virus. Virology 1994, 200, 494-503 https://doi.org/10.1006/viro.1994.1212