Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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ATG5 Expression Induced by MDMA (Ecstasy), Interferes with Neuronal Differentiation of Neuroblastoma Cells

  • Chae, Myounghee (Korea Basic Science Institute, Gwangju Center) ;
  • Rhee, Gyu-Seek (Reproductive and Developmental Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Jang, Ik-Soon (Korea Basic Science Institute, Gwangju Center) ;
  • Kim, Kwangsoo (Korea Basic Science Institute, Gwangju Center) ;
  • Lee, Ji-Hae (Department of Biological Sciences, Yong-In University) ;
  • Lee, Seung-Yeul (Department of Biological Sciences, Yong-In University) ;
  • Kim, Minjung (Department of Biological Sciences, Yong-In University) ;
  • Yang, Junyoung (Reproductive and Developmental Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Park, Junsoo (Division of Biological Sciences and Technology, Yonsei University) ;
  • Lee, Seung-Hoon (Department of Biological Sciences, Yong-In University)
  • Received : 2009.02.02
  • Accepted : 2009.03.23
  • Published : 2009.05.31
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Abstract

The amphetamine derivative 3, 4-methylenedioxymethamphetamine (MDMA) has become a popular recreational drug, and has also been shown to cause serotonergic neurotoxicity. This report shows that MDMA impairs brain development in a whole mouse embryo culture. The results of quantitative real-time PCR analysis showed that autophagy-related protein 5 (Atg5) expression is elevated in mouse embryo and neuroblastoma cells after MDMA treatment. This elevated Atg5 expression interferes with the neuronal differentiation of neuroblastoma cells such as SH-SY5Y and PC12 cells. Thus, our results suggest that the use of MDMA during pregnancy may impair neuronal development via an induction of Atg5 expression.

Keywords

Acknowledgement

Supported by : Korea Food and Drug Administration, Korea Basic Science Institute

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  2. A Variant of the Autophagy-Related 5 Gene Is Associated with Child Cerebral Palsy vol.11, pp.None, 2017, https://doi.org/10.3389/fncel.2017.00407
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