Molecules and Cells

  • 제27권5호
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  • Pages.571-575
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  • 2009
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
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ATG5 Expression Induced by MDMA (Ecstasy), Interferes with Neuronal Differentiation of Neuroblastoma Cells

  • Chae, Myounghee (Korea Basic Science Institute, Gwangju Center) ;
  • Rhee, Gyu-Seek (Reproductive and Developmental Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Jang, Ik-Soon (Korea Basic Science Institute, Gwangju Center) ;
  • Kim, Kwangsoo (Korea Basic Science Institute, Gwangju Center) ;
  • Lee, Ji-Hae (Department of Biological Sciences, Yong-In University) ;
  • Lee, Seung-Yeul (Department of Biological Sciences, Yong-In University) ;
  • Kim, Minjung (Department of Biological Sciences, Yong-In University) ;
  • Yang, Junyoung (Reproductive and Developmental Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Park, Junsoo (Division of Biological Sciences and Technology, Yonsei University) ;
  • Lee, Seung-Hoon (Department of Biological Sciences, Yong-In University)
  • 투고 : 2009.02.02
  • 심사 : 2009.03.23
  • 발행 : 2009.05.31
⟨ 이전 논문 다음 논문 ⟩

초록

The amphetamine derivative 3, 4-methylenedioxymethamphetamine (MDMA) has become a popular recreational drug, and has also been shown to cause serotonergic neurotoxicity. This report shows that MDMA impairs brain development in a whole mouse embryo culture. The results of quantitative real-time PCR analysis showed that autophagy-related protein 5 (Atg5) expression is elevated in mouse embryo and neuroblastoma cells after MDMA treatment. This elevated Atg5 expression interferes with the neuronal differentiation of neuroblastoma cells such as SH-SY5Y and PC12 cells. Thus, our results suggest that the use of MDMA during pregnancy may impair neuronal development via an induction of Atg5 expression.

키워드

과제정보

연구 과제 주관 기관 : Korea Food and Drug Administration, Korea Basic Science Institute

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피인용 문헌

  1. Autophagy Activation Is Involved in 3,4-Methylenedioxymethamphetamine (‘Ecstasy’)—Induced Neurotoxicity in Cultured Cortical Neurons vol.9, pp.12, 2014, https://doi.org/10.1371/journal.pone.0116565
  2. A Variant of the Autophagy-Related 5 Gene Is Associated with Child Cerebral Palsy vol.11, pp.None, 2017, https://doi.org/10.3389/fncel.2017.00407
  3. Journey to the Center of the Fetal Brain: Environmental Exposures and Autophagy vol.12, pp.None, 2009, https://doi.org/10.3389/fncel.2018.00118