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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Agrocybe chaxingu polysaccharide prevent inflammation through the inhibition of COX-2 and NO production

  • Lee, Byung-Ryong (Departments of Biomedical Science and Research Institute for Bioscience and Biotechnology, College of Medicine, Hallym University) ;
  • Kim, So-Young (Departments of Biomedical Science and Research Institute for Bioscience and Biotechnology, College of Medicine, Hallym University) ;
  • Kim, Dae-Won (Departments of Biomedical Science and Research Institute for Bioscience and Biotechnology, College of Medicine, Hallym University) ;
  • An, Jae-Jin (Departments of Biomedical Science and Research Institute for Bioscience and Biotechnology, College of Medicine, Hallym University) ;
  • Song, Ha-Yong (Departments of Biomedical Science and Research Institute for Bioscience and Biotechnology, College of Medicine, Hallym University) ;
  • Yoo, Ki-Yeon (Departments of Anatomy and Neurobiology, College of Medicine, Hallym University) ;
  • Kang, Tae-Cheon (Departments of Anatomy and Neurobiology, College of Medicine, Hallym University) ;
  • Won, Moo-Ho (Departments of Anatomy and Neurobiology, College of Medicine, Hallym University) ;
  • Lee, Kwang-Jae (Gangwon Agricultural Research & Extention Services) ;
  • Kim, Kyung-Hee (Gangwon Agricultural Research & Extention Services) ;
  • Joo, Jin-Ho (Department of Biological Environment, Kangwon National University) ;
  • Ham, Hun-Ju (Department of Biological Environment, Kangwon National University) ;
  • Hur, Jang-Hyun (Department of Biological Environment, Kangwon National University) ;
  • Cho, Sung-Woo (Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine) ;
  • Han, Kyu-Hyung (Departments of Biomedical Science and Research Institute for Bioscience and Biotechnology, College of Medicine, Hallym University) ;
  • Lee, Kil-Soo (Departments of Biomedical Science and Research Institute for Bioscience and Biotechnology, College of Medicine, Hallym University) ;
  • Park, Jin-Seu (Departments of Biomedical Science and Research Institute for Bioscience and Biotechnology, College of Medicine, Hallym University) ;
  • Choi, Soo-Young (Departments of Biomedical Science and Research Institute for Bioscience and Biotechnology, College of Medicine, Hallym University) ;
  • Eum, Won-Sik (Departments of Biomedical Science and Research Institute for Bioscience and Biotechnology, College of Medicine, Hallym University)
  • Published : 2009.12.31
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Abstract

The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu $\beta$-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced nitric oxide (NO) and cyclooxygenase-2 (COX-2) expression in murine macrophage Raw 264.7 cells as well as 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema in mice. The polysaccharide significantly inhibited (P < 0.01) LPS-induced iNOS and COX-2 expression levels in the cells. Furthermore, topical application of polysaccharide resulted in markedly inhibited (P < 0.01) TPA-induced ear edema in mice. These results suggest that this polysaccharide may be used for NO- and COX-2-related disorders such as inflammation and cancer.

Keywords

References

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