Blood profile test of sustained release formula of implantable bovine somatotropin in steers

비육우에서 이식형 bovine somatotropin 지속성 제형의 blood profile test

  • Accepted : 2009.03.23
  • Published : 2009.03.30

Abstract

The present study was carried out to examine the sustained release effect of the implantable bovine somatotropin (SRI-BST) formula. In the blood profile test in steers, the bovine somatotropin concentration in serum by radioimmunoassay showed the peak concentration on the first day after the implantation of the SRI-BST formula, and concentration proceeded for 5 days (p < 0.05). The insulin-like growth factor-1 concentration showed the peak concentration on the seventh day after implantation of the SRIF-BST formula, and concentration proceeded for 10 days (p < 0.05). The glucose showed the peak concentration on the first day after implantation of the SRI-BST formula, and concentration continued for 3 days (p < 0.05). The blood urea nitrogen showed the lowest concentration on the third day after implantation of the SRI-BST formula, and concentration continued for 7 days (p < 0.05). These results proved that the SRIF-BST formula was the sustained release effects in steers.

Keywords

References

  1. 김남중. Somatotropin 이식 제형 개발과 지속적 방출효과. 대한수의학회지 2008, 48, 27-32
  2. Azain MJ, Kasser TR, Sabacky MJ, Baile CA. Comparison of the growth-promoting properties of daily versus continuous administration of somatotropin in female rats with intact pituitaries. J Anim Sci 1993, 71, 384-392 https://doi.org/10.2527/1993.712384x
  3. Azain MJ, Roberts TJ, Martin RJ, Kasser TR. Comparison of daily versus continuous administration of somatotropin on growth rate, feed intake, and body composition in intact female rats. J Anim Sci 1995, 73, 1019-1029 https://doi.org/10.2527/1995.7341019x
  4. Buonomo FC, Klindt J, Yen JT. Administration of porcine somatotropin by sustained-release implant: growth factor and metabolic responses in crossbred white and genetically lean and obese boars and gilts. J Anim Sci 1995, 73, 1318-1326 https://doi.org/10.2527/1995.7351318x
  5. Cohick WS, Plaut K, Sechen SJ, Bauman DE. Temporal pattern of insulin-like growth factor-I response to exogenous bovine somatotropin in lactating cows. Domest Anim Endocrinol 1989, 6, 263-273 https://doi.org/10.1016/0739-7240(89)90020-9
  6. Collier RJ, Byatt JC, Denham SC, Eppard PJ, Fabellar AC, Hintz RL, McGrath MF, McLaughlin CL, Shearer JK, Veenhuizen JJ, Vicini JL. Effects of sustained release bovine somatotropin (sometribove) on animal health in commercial dairy herds. J Dairy Sci 2001, 84, 1098-1108 https://doi.org/10.3168/jds.S0022-0302(01)74570-5
  7. Crooker BA, McGuire MA, Cohick WS, Harkins M, Bauman DE, Sejrsen K. Effect of dose of bovine somatotropin on nutrient utilization in growing dairy heifers. J Nutr 1990, 120, 1256-1263 https://doi.org/10.1093/jn/120.10.1256
  8. Etherton TD, Bauman DE. Biology of somatotropin in growth and lactation of domestic animals. Physiol Rev 1998, 78, 745-761 https://doi.org/10.1152/physrev.1998.78.3.745
  9. Gallo L, Bailoni L, Schiavon S, Carnier P, Ramanzin M, Andrighetto I, Bittante G. Effect of slow-release somatotropin on the pattern of milk yield between and within injection intervals. J Dairy Sci 1997, 80, 46-51 https://doi.org/10.3168/jds.S0022-0302(97)75911-3
  10. Gallo L, Cassandro M, Carnier P, Mantovani R, Ramanzin M, Bittante G, Tealdo E, Casson P. Modeling response to slow-releasing somatotropin administered at 3- or 4-week intervals. J Dairy Sci 1994, 77, 759-769 https://doi.org/10.3168/jds.S0022-0302(94)77010-7
  11. Hammond BG, Collier RJ, Miller MA, McGrath M, Hartzell DL, Kotts C, Vandaele W. Food safety and pharmacokinetic studies which support a zero (0) meat and milk withdrawal time for use of sometribove in dairy cows. Ann Rech Vet 1990, 21 (Suppl 1), 107S-120S
  12. Hancock DL, Preston RL. Titration of the recombinant bovine somatotropin dosage that maximizes the anabolic response in feedlot steers. J Anim Sci 1990, 68, 4117-4121 https://doi.org/10.2527/1990.68124117x
  13. Harn NR, Jeng YN, Kostelc JG, Middaugh CR. Spectroscopic analysis of highly concentrated suspensions of bovine somatotropin in sesame oil. J Pharm Sci 2005, 94, 2487-2495 https://doi.org/10.1002/jps.20464
  14. Hartnell GF, Franson SE, Bauman DE, Head HH, Huber JT, Lamb RC, Madsen KS, Cole WJ, Hintz RL. Evaluation of sometribove in a prolonged-release system in lactating dairy cows--production responses. J Dairy Sci 1991, 74, 2645-2663 https://doi.org/10.3168/jds.S0022-0302(91)78443-9
  15. Hodate K, Ozawa A, Johke T. Effect of a prolonged release formulation of recombinant bovine somatotropin on plasma concentrations of hormones and metabolites, and milk production in dairy cows. Endocrinol Jpn 1991, 38, 527-532 https://doi.org/10.1507/endocrj1954.38.527
  16. Hu OY, Chang WC, Yang TS. Pharmacokinetic properties of recombinant porcine growth hormone in pigs. Pharmacology 1995, 50, 63-68 https://doi.org/10.1159/000139267
  17. Jenny BF, Grimes LW, Pardue FE, Rock DW, Patterson DL. Lactational response of Jersey cows to bovine somatotropin administered daily or in a sustained-release formulation. J Dairy Sci 1992, 75, 3402-3407 https://doi.org/10.3168/jds.S0022-0302(92)78116-8
  18. Kajkowski EM, Price LA, Pausch MH, Young KH, Ozenberger BA. Investigation of growth hormone releasing hormone receptor structure and activity using yeast expression technologies. J Recept Signal Transduct Res 1997, 17, 293-303 https://doi.org/10.3109/10799899709036610
  19. Klindt J, Buonomo FC, Yen JT. Administration of porcine somatotropin by sustained-release implant: growth, carcass, and sensory responses in crossbred white and genetically lean and obese boars and gilts. J Anim Sci 1995, 73, 1327-1339 https://doi.org/10.2527/1995.7351327x
  20. Lemal D, Renaville R, Claes V, Ruelle L, Fabry J, Burny A, Underwood LE, Ketelslegers JM. Effect of pituitary somatotropin injections on plasma insulin-like growth factor I and somatotropin profiles in growing heifers. J Anim Sci 1989, 67, 2715-2723 https://doi.org/10.2527/jas1989.67102715x
  21. Pineda LM, Busing M, Meinig RP, Gogolewski S. Bone regeneration with resorbable polymeric membranes. III. Effect of poly(L-lactide) membrane pore size on the bone healing process in large defects. J Biomed Mater Res 1996, 31, 385-394 https://doi.org/10.1002/(SICI)1097-4636(199607)31:3<385::AID-JBM13>3.0.CO;2-I
  22. Roeder RA, Garber MJ, Dalke BS, Kasser TR, Veenhuizen J, Schelling GT. Effects of recombinant bovine somatotropin implants on serum concentrations of somatotropin, insulin-like growth factor-I and blood urea nitrogen in steers. Growth Regul 1994, 4, 101-107 https://doi.org/10.1007/BF02266948
  23. Sadaf S, Khan MA, Akhtar MW. Production of bubaline somatotropin by auto-induction in Escherichia coli. Biotechnol Appl Biochem 2007, 47, 21-26 https://doi.org/10.1042/BA20060154
  24. Slaba J, Krejcí P, Skarda J, Huybrechts LM, Decuypere E, Herrmann H. Plasma profiles of somatotropin and IGF-I in diary cows following application of two preparations of recombinant bovine somatotropin in a sustained release vehicle. Physiol Res 1994, 43, 37-43
  25. Trepod CM, Mott JE. A spontaneous runaway vector for production-scale expression of bovine somatotropin from Escherichia coli. Appl Microbiol Biotechnol 2002, 58, 84-88 https://doi.org/10.1007/s00253-001-0859-6
  26. Warren WC, Bentle KA, Schlittler MR, Schwane AC, O'Neil JP, Bogosian G. Increased production of peptide deformylase eliminates retention of formylmethionine in bovine somatotropin overproduced in Escherichia coli. Gene 1996, 174, 235-238 https://doi.org/10.1016/0378-1119(96)00086-8
  27. Yen JT, Klindt J, Kerr BJ, Buonomo FC. Lysine requirement of finishing pigs administered porcine somatotropin by sustained-release implant. J Anim Sci 2005, 83, 2789-2797 https://doi.org/10.2527/2005.83122789x
  28. Zhao X, McBride BW, Trouten-Radford LM, Golfman L, Burton JH. Somatotropin and insulin-like growth factor-I concentrations in plasma and milk after daily or sustained-release exogenous somatotropin administrations. Domest Anim Endocrinol 1994, 11, 209-216 https://doi.org/10.1016/0739-7240(94)90028-0