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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Association of polymorphisms in thromboxane A2 receptor and thromboxane A synthase 1 with cerebral infarction in a Korean population

  • Park, Sun-Ah (Department of Neurology, Soonchunhyang University Bucheon Hospital) ;
  • Park, Byung-Lae (Department of Genetic Epidemiology, SNP Genetics, Inc.) ;
  • Park, Jeong-Ho (Department of Neurology, Soonchunhyang University Bucheon Hospital) ;
  • Lee, Tae-Kyeong (Department of Neurology, Soonchunhyang University Bucheon Hospital) ;
  • Sung, Ki-Bum (Department of Neurology, Soonchunhyang University Bucheon Hospital) ;
  • Lee, You-Kyoung (Department of Laboratory Medicine, Soonchunhyang University Bucheon Hospital) ;
  • Chang, Hun-Soo (Genome Research Center for Allergy and Respiratory Diseases, Division of Allergy and Respiratory Medicine) ;
  • Park, Choon-Sik (Genome Research Center for Allergy and Respiratory Diseases, Division of Allergy and Respiratory Medicine) ;
  • Shin, Hyoung-Doo (Department of Genetic Epidemiology, SNP Genetics, Inc.)
  • Published : 2009.04.30
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Abstract

Thromboxane A2 (TBXA2) is a potent vasoconstrictor in cerebral circulation and is a known contributor to the pathogenesis of cerebral infarction. Thromboxane A2 synthase 1 (TBXAS1) and thromboxane A2 receptors (TBXA2R) are key components in TBXA2 function. We examined whether genetic variants in TBXA2R and TBXAS1 are risk factors for cerebral infarction by genotyping 453 Korean patients with noncardiogenic cerebral infarction and 260 controls. A few, specific polymorphisms in the TBXA2R (-3372G>C, +4710T>C and 4839T>C) and TBXAS1 (+16184G>T, +141931A>T and +177729G>A) genes were chosen and investigated. Logistic regression showed the frequencies of TBXAS1+16184G>T and TBXAS1-ht3 were significantly more frequent in cerebral infarction (P = 0.002, OR = 2.75 and P = 0.01, OR = 1.57, respectively), specifically in small-artery occlusion (SAO) type of cerebral infarction (P = 0.0003 and 0.005, respectively). These results suggest specific TBXAS1 gene polymorphisms may be a useful marker for development of cerebral infarction, especially SAO type in Korean population.

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