DOI QR코드

DOI QR Code

Every Single Cell Clones from Cancer Cell Lines Growing Tumors In Vivo May Not Invalidate the Cancer Stem Cell Concept

  • Li, Fengzhi (Departments of Pharmacology and Therapeutics, Roswell Park Cancer Institute)
  • 투고 : 2008.12.15
  • 심사 : 2009.02.16
  • 발행 : 2009.04.30

초록

We present the result of our research on the tumorigenic ability of single cell clones isolated from an aggressive murine breast cancer cell line in a matched allografting mouse model. Tumor formation is basically dependent on the cell numbers injected per location. We argue that in vivo tumor formation from single cell clones, isolated in vitro from cancer cell lines, may not provide conclusive evidence to disprove the cancer stem cell (CSC) theory without additional data.

키워드

과제정보

연구 과제 주관 기관 : NIH, Charlotte Geyer Foundation

참고문헌

  1. Danovi, S.A. (2009). Cancer stem cells: common as muck. Nat. Rev. Cancer 9, 6-7 https://doi.org/10.1038/nrc2563
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  6. Zheng, X., Shen, G., Yang, X., and Liu, W. (2007). Most C6 cells are cancer stem cells: evidence from clonal and population analyses. Cancer Res. 67, 3691-3697 https://doi.org/10.1158/0008-5472.CAN-06-3912

피인용 문헌

  1. Cancer cell sensitivity to bortezomib is associated with survivin expression and p53 status but not cancer cell types vol.29, pp.1, 2009, https://doi.org/10.1186/1756-9966-29-8
  2. Silencing oncogene expression in cervical cancer stem-like cells inhibits their cell growth and self-renewal ability vol.18, pp.12, 2009, https://doi.org/10.1038/cgt.2011.58
  3. TSSC3 overexpression reduces stemness and induces apoptosis of osteosarcoma tumor-initiating cells vol.17, pp.8, 2009, https://doi.org/10.1007/s10495-012-0734-1