Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Effect of long term treatment of aqueous extract of Enicostemma littorale in Type 2 diabetic patients

  • Published : 2009.03.31
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Abstract

We have evaluated the effect of long term treatment of Enicostemma littorale (E. littorale) in type 2 diabetic patients taking pills of aqueous extract of E. littorale regularly as a complimentary medicine for at least 9 months. The effects of E. littorale on glycemic control, lipid profile, cardiac function and DNA damage in these patients were compared with those who had not been regular in taking E. littorale but regular in taking other conventional anti-diabetics. Our data suggest that, E. littorale can maintain normal blood glucose, serum insulin, serum triglycerides levels of type 2 diabetic patients if taken regularly. E. littorale also improves insulin sensitivity, and normalize disturbed lipogram and elevated creatinine levels, thereby produces beneficial effect in preventing cardiovascular complications and may preserve the kidney function. The finding that E. littorale also prevents DNA damage suggest a long term effect in diabetic patients. E. littorale thus can be considered as safe supplementary therapy for a long term and effective management of type 2 diabetic patients.

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References

  1. Chaudhuri RK, Singh AK, Ghosal S. (1975) Chemical constituents of gentianaceae XVIII Structure of Enicoflavine Monoterpene alkaloids from Enicostemma hyssopifolium. Chem. India (London) 3, 127-128
  2. Craig JW. (1980) Clinical implications of the new diabetes classification. Postgra Med. 68, 122-123
  3. Defronzo RA, Gannarssopn R, Bjorkman O, Olsson M, Wahren J. (1985) Effect of insulin peripheral and splanchinc glucose metabolism in non-insulin dependent (type-2) diabetes mellitus. J. clin. invest. 76, 149-155 https://doi.org/10.1172/JCI111938
  4. Desai PD, Ganguly AK, Govindachari TR, Joshi BS, Kamat VN, Manmade AH, Mohamed PA, Nagle SK, Nayak RH, Saksena AK, Sathe SS, Vishwanathan N. (1966) Chemical investigation of some Indian Medicinal Plants: Part II. Indian J. Chem. 4, 457-459
  5. Eisenbarth GS, Kahn CR. (1990) Etiology and pathogenesis of diabetes mellitus. In Becker KL. Ed principles and Practice of Endocrinology and Metabolism. JB Lippincott: Philadelphia, 1074-1098
  6. Ghosal S, Singh AK, Sharma PV, Chaudhuri RK. (1974) Chemical constituents of Gentianacceae IX: natural occurrence of Erythrocentaurin in Enicostemma hissopifolium and Swertia lawii. J. Pharm. Sci. 63, 944-945 https://doi.org/10.1002/jps.2600630632
  7. Gupta SS, Seth CB, Variyar MC. (1962) Experimental studies on pituitary-diabetes Part I, Inhibitory effect of a few Ayurvedic antidiabetic remedies on pituitary extract induced hyperglycemia in albino rats. Indian J. Med. Res. 50, 73-81
  8. Hansesn KF, Dahl Jorgensen, Lauritzen T, Feldt ras mussen B, Brinchmann Hansen o Deckert T. (1986) Diabetic control and microvascular complications. The near normoglyceia experience. Diabetologu. 29, 677-684 https://doi.org/10.1007/BF00870275
  9. Hayden JM, Reaven PD. (2000) Cardiovascular disease in diabetes mellitus type 2: a potential role for noel cardiovascular risk factors. Curr. Opin. Lipidol. 11, 519-528 https://doi.org/10.1097/00041433-200010000-00010
  10. James RW. (2001) Diabetes and other coronary heart disease risk equivalents. Curr. Opin. Lipidol. 12, 425-431 https://doi.org/10.1097/00041433-200108000-00009
  11. Kalseen GA, Tanser PH, Marpole D, Agrawal JB. (1973) Adaptation of the coronary circulation to primary myocardial disease. Recent Adv. Cardiac. Struc. Metab. 3, 161-168
  12. King G, Goodman D. (1985) Receptors and growth promoting effects of insulin and insulin like growth factors on cells from bovine retinal capillaries and aorta. J. clin. invest. 75, 1028-1036 https://doi.org/10.1172/JCI111764
  13. Kolterman OG, Garu R, Griffin J, Burstein P, Insel J. (1981) Receptor defects contribute to the insulin resisitance in non-insulin dependent diabetes mellitus. J. clin. invest. 68, 957-969 https://doi.org/10.1172/JCI110350
  14. Macmohan S, Peto R, Cutler J, Collins R, Sorlie P, Neaton J, Abbott R, Godwin J, Dyer A, Stamler J. (1990) Blood pressure stroke and coronary heart disease. Lancet 335, 765-774 https://doi.org/10.1016/0140-6736(90)90878-9
  15. Murali B, Upadhyaya UM, Goyal RK. (2002) Effect of chronic treatment with Enicostemma littorale in non-insulin dependent diabetic (NIDDM) rats. J. Ethnopharmacol. 81, 199-204 https://doi.org/10.1016/S0378-8741(02)00077-6
  16. Natarajan PN, Prasad S. (1972) Chemical investigation of Enicotemma littorale. Planta Med. 22, 42-46 https://doi.org/10.1055/s-0028-1099580
  17. Rai J, Thakar KA. (1966) Chemical investigation of Enicotemma littorale Blume. Curr. Sci. 35, 148-149
  18. Rasch R. (1979) Prevention of diabetic glomerulopathy in streptozotoxin-diabetic rates by insulin treatment. Kidney size and glomerular volume. Diabetologiia 16, 125-28 https://doi.org/10.1007/BF01225462
  19. Regan TJ, Lyons MM, Ahmed SS, Levinson GE, Oldewurtel HA, Ahmad MR, Haider B. (1977) Evidence for cardiomyopathy in familial diabetes mellitus. J. Clin. Invest. 60, 885-899 https://doi.org/10.1172/JCI108843
  20. Reichard P, Rosenqvist U. (1989) Nephropathy is delayed by intensified insulin treatment in patiendts with insulin dependent diabetes mellitus and retinopathy. J. int. med, 226, 81-87 https://doi.org/10.1111/j.1365-2796.1989.tb01359.x
  21. Retnam KR, DeBritto AJ. (1988) Preliminary phyochemical screening of three medcinal plants of tirunelveli hills. J. Econ. Tax. Bot. 22, 677-681
  22. Taskinen M. (1997) Triglyceride is the major atherogenic lipid in NIDDM. Diabet Met. Rev. 13, 93-98 https://doi.org/10.1002/(SICI)1099-0895(199706)13:2<93::AID-DMR187>3.0.CO;2-6
  23. Upadhyay UM, Goyal RK. (2004) Efficacy of Enicostemma littorale in type 2 diabetic patients. Phytother. Res. 18, 233-235 https://doi.org/10.1002/ptr.1434
  24. Vishwakaarma SL, Rajani M, Bagul MS, Goyal RK. (2004) A rapid method for the isolation of swertiamarin from Enicostemma littorale. Phara. Bio. 42, 400-403 https://doi.org/10.1080/13880200490885095
  25. Vishwakarma SL, Goyal RK. (2004) A sensitive HPTLC method for estimation of swertiamarin in Enicostemma littorale bume swetia chirata (wall) Clarke, and formulations containing Enicostemma littorale. J. Planar. Chromat. 17, 128-132 https://doi.org/10.1556/JPC.17.2004.2.8
  26. Vishwakarma SL, Rajani M, Goyal RK. (2003) Comparatie antidiabetic actiiy of different fractions of Enicostemma littorale blume in streptoxotocine induced NIDDM rats. Orient. J. Pharm. Exp. Med. 3, 196-204 https://doi.org/10.3742/OPEM.2003.3.4.196