Food Science and Preservation (한국식품저장유통학회지)

The Korean Society of Food Preservation (한국식품저장유통학회)
권호 표지

Effect of Low-Molecular-Weight Collagen Peptide Extract Isolated from Scales of the Flathead Mullet (Mugil cephalus) on Lipid Metabolism in Hyperlipidemic Rats

숭어(Mugil cephalus) 비늘의 저분자 콜라겐 펩타이드 추출물이 고지혈증 흰쥐의 혈청 지질대사에 미치는 영향

  • Kim, Han-Soo (Department of Food Science & Technology, Pusan National University) ;
  • Seong, Jong-Hwan (Department of Food Science & Technology, Pusan National University) ;
  • Lee, Young-Guen (Department of Food Science & Technology, Pusan National University) ;
  • Xie, Cheng-Liang (Department of Food Science & Technology, Pusan National University) ;
  • Choi, Woo-Seok (Department of Food Science & Technology, Pusan National University) ;
  • Kim, Su-Ha (Department of Food Science & Technology, Pusan National University) ;
  • Yoon, Ho-Dong (Food & Safety Research Center, National Fisheries Research & Development Institute)
  • 김한수 (부산대학교 식품공학과) ;
  • 성종환 (부산대학교 식품공학과) ;
  • 이영근 (부산대학교 식품공학과) ;
  • ;
  • 최우석 (부산대학교 식품공학과) ;
  • 김수하 (부산대학교 식품공학과) ;
  • 윤호동 (국립수산과학원 식품안전연구단)
  • Published : 2009.12.30
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Abstract

The objective of this study was to investigate the effects of ingestion of low-molecular-weight collagen peptides on lipid composition, blood glucose level, and enzyme activities in the serum of hyperlipidemic rats fed experimental diets for 5 weeks. Concentrations of total cholesterol, low-density lipoprotein (LDL)-cholesterol, free cholesterol, triglyceride (TG), phospholipid (PL), and blood glucose, the atherosclerotic index, and the cholesteryl ester ratio were higher in serum of the hyperlipidemic group (CW group), and the cholesterol-plus-collagen peptides extract group (CCP group) than in the control group (BG group basal diet plus water). However, the concentrations of total cholesterol, LDL-cholesterol, free cholesterol, TG, PL, and blood glucose, the atherosclerotic index, and the cholesteryl ester ratio in serum were lower in the CCP group than in the CW group. By contrast, the ratio of HDL-cholesterol to total cholesterol and the absolute HDL-cholesterol level in the CCP group were higher than in the CW group. The activities of alkaline phosphatase (ALP) and aminotransferases (AST, ALT) in serum were lower in the CCP group than in the hyperlipidemic CW group. The results indicate that an extract of low-molecular-weight collagen peptides effectively inhibited increases in lipid elevation, blood glucose level, and enzyme activities, in the serum of hyperlipidemic rats.

고지혈증 흰쥐에 있어서, 숭어(Mugil cephalus) 비늘에서 추출 제조된 저분자 콜라겐 펩타이드 추출물의 급여가 혈청 지질개선 효과 및 지질대사 이상 등에 관여하는 지질성분 및 효소의 활성 변동을 검토하기 위하여 Sprague Dawley계 흰쥐 수컷을 사용하여 본 실험을 행하였다. 기본식이만을 급여한 대조군인 BG군을 비롯한 고지혈증 유발군(CW군), 고지혈증 유발에 콜라겐 펩타이드를 섭취시킨 군(CCP군)을 5주간 실험사육하였다. 혈청 총 콜레스테롤, 동맥경화지수, LDL-콜레스테롤, 유리 콜레스테롤, 콜레스테롤 에스테르 비, 중성지방 및 인지질 농도 및 혈당 농도 등은 저분자 콜라겐 펩타이드 추출물을 섭취시킨 군(CCP군)에서 농도가 감소되는 것으로 나타났다. 한편, HDL-콜레스테롤 및 총 콜레스테롤에 대한 HDL-콜레스테롤 비 등은 콜라겐 펩타이드 급여(CCP군)에 의해서 증가되는 것으로 나타났다. 혈청 중 alkaline phosphatase (ALP) 및 aminotransferase (AST, ALT)의 활성은 고지혈증을 유도 시킨 후 콜라겐 펩타이드를 급여시킴으로써 감소되는 것으로 나타났다. 이상과 같은 결과들을 미루어 볼 때, 저분자 콜라겐 펩타이드 추출물이 고지혈증 유발 흰쥐의 혈청 지질대사 이상 등에서 오는 고지혈증의 예방 및 개선에 효과가 있을 것으로 추정된다.

Keywords

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