Molecular & Cellular Toxicology

The Korean Society of Toxicogenomics and Toxicoproteomics (대한독성유전 단백체학회)
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Polymorphisms of Transmembrane Channel-like 1 Gene are Associated with Kawasaki Disease in Korean Population

  • Lim, Tae-Wan (Department of Anesthesiology and Pain Medicine, Seoul National University Hospital) ;
  • Kim, Su-Kang (Kohwang Medical Research Institute, School of Medicine, Kyung Hee University) ;
  • Ban, Ju-Yeon (Department of Dental Pharmacology, College of Dentistry, Dankook University) ;
  • Chung, Joo-Ho (Kohwang Medical Research Institute, School of Medicine, Kyung Hee University) ;
  • Song, Jeong-Yoon (East-West Neo Medical Center, School of Medicine, Kyung Hee University) ;
  • Yoon, Kyung-Lim (East-West Neo Medical Center, School of Medicine, Kyung Hee University) ;
  • Park, Sung-Wook (Department of Anesthesiology and Pain Medicine, School of Medicine, Kyung Hee University) ;
  • Kim, Keon-Sik (Department of Anesthesiology and Pain Medicine, School of Medicine, Kyung Hee University) ;
  • Shin, Ok-Young (Department of Anesthesiology and Pain Medicine, School of Medicine, Kyung Hee University)
  • Published : 2009.12.31
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Abstract

Kawasaki disease (KD) is believed to be infectious but etiology and the mechanism of development remain elusive. The aim of this study was to investigate the association between transmembrane channel-like 1 (TMC1) gene and KD. One hundred nine KD patients and 424 normal controls were enrolled. Of all KD patients, 34 developed coronary artery lesions (CALs). Eleven single nucleotide polymorphisms (SNPs) within TMC1 gene were selected and SNP genotyping was performed by the direct sequencing. Genotype frequencies were analyzed with the SNPAnalyzer, Helixtree, and SNPStats programs. In the present study, six SNPs (rs7851577, rs10781105, rs2589615, rs1663743, rs1373628, and rs1373626) were significantly associated with the risk of KD. In further haplotype analysis, one haplotype (CGGACCCT) showed a significant association between KD and control groups. These results suggest that TMC1 gene may be a susceptibility gene for KD in Korean population.

Keywords

References

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