References
- Kitts, D. D., Wijewickreme, A. N. and Hu, C. : Antioxidant properties of a North American ginseng extract. Mol Cell Biochem. 203, 1-10 (2000) https://doi.org/10.1023/A:1007078414639
- Corbit, R. M., Ferreira, J. F., Ebbs, S. D. and Murphy, L. L. : Simplified extraction of ginsenosides from American ginseng (Panax quinquefolius L.) for highperformance liquid chromatography-ultraviolet analysis. J Agric Food Chem. 53, 9867-73 (2005) https://doi.org/10.1021/jf051504p
- Yun, T. K. : Panax ginsenga non-organ-specific cancer preventive? Lancet Oncol. 2, 49-55 (2001) https://doi.org/10.1016/S1470-2045(00)00196-0
- Bloch, A. and Thomson, C. A. : Position of the American dietetic association : phytochemicals and functional foods. J Am Dietet Assoc. 95, 493-96 (1995) https://doi.org/10.1016/S0002-8223(95)00130-1
- Zab ocka, A. and Janusz, M. : The two faces of reactive oxy-gen species. Postepy Hig Med Dosw. 26, 62,118-24 (2008)
- Hofseth, L. J. and Wargovich, M. J. : Inflammation,Cancer, and Targetsof Ginseng1 J. Nutr. 137, 183S185S (2007) https://doi.org/10.1093/jn/137.1.183S
- Attele, A.S., Wu, J.A. and Yuan, C.S. : Ginseng pharmacology: multiple constituents and multiple actions. Biochem. Pharmacol. 58, 1685-1693 (1999) https://doi.org/10.1016/S0006-2952(99)00212-9
- Lee, T.K., Johnke, R.M., Allison, R.R., O'Brien, K.F. and Dobbs Jr., L.J. : Radioprotective potential of ginseng. Mutagenesis. 20, 237-243 (2005) https://doi.org/10.1093/mutage/gei041
- Liou, C.J., Huang, W.C. and Tseng, J. : Long-term oral administration of ginseng extract modulates humoral immune response and spleen cell functions. Am. J. Chin. Med. 33, 651-661 (2005) https://doi.org/10.1142/S0192415X05003247
- Lee, S.J., Sung, J.H., Lee, S.J., Moon, C.K. and Lee, B.H. : Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin. Cancer Lett. 144, 39-43 (1999) https://doi.org/10.1016/S0304-3835(99)00188-3
- Kitts, D.D., Wijewickreme, A.N. and Hu, C. : Antioxidant properties of a North American ginseng extract. Mol. Cell. Biochem. 203, 1-10 (2000) https://doi.org/10.1023/A:1007078414639
- Bae, J.W. and Lee, M.H. : Effect and putative mechanism of action of ginseng on the formation of glycated hemoglobin in vitro. J. Ethnopharmacol. 90,137-140 (2004) https://doi.org/10.1016/j.jep.2003.12.008
- Mehendale, S.R., Aung, H.H., Yin, J.J., Lin, E., Fishbein, A., Wang, C.Z., Xie, J.T. and Yuan, C.S. : Effects of antioxidant herbs on chemotherapyinduced nausea and vomiting in a rat-pica model. Am. J. Chin. Med. 32, 897-905 (2004) https://doi.org/10.1142/S0192415X04002508
- Cross, C.E., Halliwell, B., Borish, E.T., Pryor, W.A., Ames, B.N., Saul, R.L., McCord, J.M. and Harman, D. : Oxygen radicals and human disease. Ann Intern Med. 107: 526-545(1987) https://doi.org/10.7326/0003-4819-107-4-526
- Volpert, R. and Elstner, E.F. : Biochemical activities of propolis extracts. I. Standardization and antioxidative properties of ethanolic and aqueous derivatives. Z. Naturforsch. 48C, 851-857 (1993)
- Kovacs, P., Juranek, I., Stankovicova, T. and Svec, P. : Lipid peroxidation during acute stress. Pharmazie. 51, 51-53 (1996)
- Liu, J., Wang, X., Shigenaga, M.K., Yeo, H.C., Mori, A. and Ames, B.N. : Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats. FASEB J. 10: 1532-8 (1996) https://doi.org/10.1096/fasebj.10.13.8940299
- Shaheen, A.A., Abd El-Fattah, A. and Gad, M.Z. : Effect of various stressors on the level of lipid peroxide, antioxidants and Na+, K+-ATPase activity in rat brain. Experientia. 52, 336-9 (1996) https://doi.org/10.1007/BF01919536
- Achike, F.I. and Kwan, C.Y. : Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway. Clin Exp Pharmacol Physiol. 30(9):605-15 (2003) https://doi.org/10.1046/j.1440-1681.2003.03885.x
- Kanter, M.M, Nolte, L.A. and Holloszy, J.O. : Effects of an antioxidand vitamin mixture on lipid peroxidation at rest and postexercise. J. Appl. Physiol. 72(2), 965-969(1993) https://doi.org/10.1152/jappl.1993.74.2.965
- Seals, D.F. and Courtneidge, S.A. : The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev. 17: 7-30 (2003) https://doi.org/10.1101/gad.1039703
-
Black, R.A., Rauch, C.T., Kozlosky, C.J., Peschon, J.J., Slack, J.L., Wolfson, M.F., Castner, B.J., Stocking, K.L., Reddy, P., Srinivasan, S., Nelson, N., Boiani, N., Schooley, K.A., Gerhart, M., Davis, R., Fitzner, J.N., Johnson, R.S., Paxton, R.J., March, C.J. and Cerretti, D.P. : A metalloproteinase disintegrin that releases tumour-necrosis factor-
$\alpha$ from cells. Nature. 385, 729-33 (1997) https://doi.org/10.1038/385729a0 - Moss, M.L., Jin, S.L., Milla, M.E., Bickett, D.M., Burkhart, W., Carter, H.L., Chen, W.J., Clay, W.C., Didsbury, J.R., Hassler, D., Hoffman, C.R., Kost, T.A., Lambert, M.H., Leesnitzer, M.A., McCauley, P., McGeehan, G., Mitchell, J., Moyer, M., Pahel, G., Rocque, W., Overton, L.K., Schoenen, F., Seaton, T., Su, J.L. and Becherer, J.D. : Cloning of a disintegrin metalloproteinase that processes precursor tumournecrosis factor-alpha. Nature. 385, 733-6. (1997) https://doi.org/10.1038/385733a0
- Sahin, U., Weskamp, G., Kelly, K., Zhou, H.M., Higashiyama, S., Peschon, J., Hartmann, D., Saftig, P. and Blobel, C.P. : Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol. 164, 769-79. (2004) https://doi.org/10.1083/jcb.200307137
- Berry, M.A., Hargadon, B., Shelley, M., Parker, D., Shaw, D.E., Green, R.H., Bradding, P., Brightling, C.E., Wardlaw, A.J. and Pavord, I.D. : Evidence of a role of tumor necrosis factor in refractory asthma. N. Engl. J. Med. 354, 697-708 (2006) https://doi.org/10.1056/NEJMoa050580
- Hehlgans, T. and Pfeffer, K. : The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games. Immunology. 115, 1-20 (2005) https://doi.org/10.1111/j.1365-2567.2005.02143.x
-
Horiuchi, K., Kimura, T., Miyamoto, T., Takaishi, H., Okada, Y., Toyama, Y. and Blobel, C.P. : TNF-
$\alpha$ -converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J. Immunol. 179, 2686-2689 (2007) https://doi.org/10.4049/jimmunol.179.5.2686 - Scott, D.L. and Kingsley, G.H. : Tumor necrosis factor inhibitors for rheumatoid arthritis. N. Engl. J. Med. 355, 704-712 (2006) https://doi.org/10.1056/NEJMct055183
- Funk, C.D. : Prostaglandins and leukotrienes: advances in eicosanoid biology. Science, 294, 1871-5 (2001) https://doi.org/10.1126/science.294.5548.1871
- Bar-Shai, M., Carmeli, E., Ljubuncic, P. and Reznick, A.Z. : Exercise and immobilization in aging animals: the involvement of oxidative stress and NF-kappaB activation. Free Radic Biol Med. 44(2), 202-14 (2008) https://doi.org/10.1016/j.freeradbiomed.2007.03.019
- DasGupta, S., Murumkar, P.R., Giridhar, R. and Yadav, M.R. : Current perspective of TACE inhibitors: a review. Bioorg Med Chem. 17(2), 444-59 (2009) https://doi.org/10.1016/j.bmc.2008.11.067
- Kang, K.S., Kim, H.Y., Pyo, J.S. and Yokozawa, T. : Increase in the free radical scavenging activity of ginseng by heatprocessing. Biol Pharm Bull. 29(4), 750-4 (2006) https://doi.org/10.1248/bpb.29.750
- Sachdev, S. and Davies, K.J. : Production, detection, and adaptive responses to free radicals in exercise. Free Radic Biol Med. Jan 15, 44(2), 215-23 (2008) https://doi.org/10.1016/j.freeradbiomed.2007.07.019
- Kim, S.H., Park, K.S., Chang, M.J. and Sung, J.H. : Effects of Panax ginseng extract on exercise-induced oxidative stress. J Sports Med Phys Fitness. 45(2), 178-82 (2005)
- Voces, J., Cabral de Oliveira A.C., Prieto, J.G., Vila, L., Perez, A.C., Duarte, I.D. and Alvarez, A.I. : Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats. Braz J Med Biol Res. 37(12), 1863-71 (2004) https://doi.org/10.1590/S0100-879X2004001200012
- Taylor, D.L., Edwards, A.D. and Mehmet, H. : Oxidative metabolism, apoptosis and perinatal brain injury. Brain Pathol. 9, 93-117 (1999) https://doi.org/10.1111/j.1750-3639.1999.tb00213.x
- Shah, Z.A., Gilani, R.A., Sharma, P. and Vohora, S.B. : Cerebroprotective effect of Korean ginseng tea against global and focal models of ischemia in rats. J Ethnopharmacol. 3, 101 (1-3), 299-307 (2005) https://doi.org/10.1016/j.jep.2005.05.002
- Maffei, Facino R., Carini, M., Aldini, G., Berti, F. and Rossoni, G. : Panax ginseng administration in the rat prevents myocardial ischemia-reperfusion damage induced by hyperbaric oxygen: evidence for an antioxidant intervention. Planta Med. 65(7), 614-9 (1999) https://doi.org/10.1055/s-1999-14034
- Xie, J.T., Shao, Z.H., Vanden, Hoek., T.L, Chang, W.T., Li, J., Mehendale, S., Wang, C.Z., Hsu, C.W., Becker, L.B., Yin, J.J. and Yuan, C.S. : Antioxidant effects of ginsenoside Re in cardiomyocytes. Eur J Pharmacol. Feb 27; 532(3), 201-7, (2006) https://doi.org/10.1016/j.ejphar.2006.01.001
- Stohs, S.J. and Bagchi, D. : Oxidative mechanisms in the toxicity of metal ions. Free Radical Biology & Medicine, Vol. 18, No. 2, pp. 321-336, (1995) https://doi.org/10.1016/0891-5849(94)00159-H
- Yazihan, N., Ataoglu, H., Akcil, E., Yener, B., Salman, B. and Aydin, C. : Midkine secretion protects Hep3B cells from cadmium induced cellular damage, World J Gastroenterol; 14(1), 76-80 (2008) https://doi.org/10.3748/wjg.14.76
- Lasfer, M., Vadrot, N., Aoudjehane, L., Conti, F., Bringuier, A.F., Feldmann, G. and Reyl-Desmars, F. : Cadmium induces mitochondria-dependent apoptosis of normal human hepatocytes. Cell Biol Toxicol. 24(1), 55-62 (2008) https://doi.org/10.1007/s10565-007-9015-0
- Xie, J. and Shaikh, Z.A. : Cadmium-induced apoptosis in rat kidney epithelial cells involves decrease in nuclear factorkappa B activity. Toxicol Sci. 91(1), 299-308 (2006) https://doi.org/10.1093/toxsci/kfj131
- Shukla, R. and Kumar, M. : Role of Panax ginseng as an antioxidant after cadmium-induced hepatic injuries. Food Chem Toxicol. 8 (2009) https://doi.org/10.1016/j.fct.2009.01.002
-
Kahn, S.E. : The relative contributions of insulin resistance and
$\beta$ -cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 46, 3-19, (2003) https://doi.org/10.1007/s00125-003-1190-9 -
Lenzen, S. : Oxidative stress: the vulnerable
$\beta$ -cell. Biochem. Soc. Trans. 36, 343-347 (2008) https://doi.org/10.1042/BST0360343 - Lenzen, S., Drinkgern, J. and Tiedge, M. : Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radical Biol. Med. 20, 463-466 (1996) https://doi.org/10.1016/0891-5849(96)02051-5
- Tiedge, M., Lortz, S., Drinkgern, J. and Lenzen, S. : Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 46, 1733-1742 (1997) https://doi.org/10.2337/diabetes.46.11.1733
-
Kim, H.Y. and Kim, K. : Protective Effect of Ginseng on Cytokine-Induced Apoptosis in Pancreatic
$\hat{a}$ -Cells, J. Agric. Food Chem. 55, 2816-2823 (2007) https://doi.org/10.1021/jf062577r - Newsholme, P., Haber, E.P., Hirabara, S.M., Rebelato, E.L., Procopio, J., Morgan, D., Oliveira-Emilio, H.C., Carpinelli, A.R. and Curi, R. : Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. J Physiol 583, 9-24, (2007) https://doi.org/10.1113/jphysiol.2007.135871
- Zhang, C.Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A.J., Boss, O., Kim, Y.B., Zheng, X.X., Wheeler, M.B., Shulman, G.I., Chan, C.B. and Lowell, B.B. : Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell, 105(6), 745-755 (2001) https://doi.org/10.1016/S0092-8674(01)00378-6
- Hagen, T. and Vidal-Puig, A. : Mitochondrial uncoupling proteins in human physiology and disease. Minerva Med, 93(1), 41-57 (2002)
- Mattson, M.P. and Liu, D. : Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death. Biochem Biophys Res Commun, 304(3), 539-549 (2003) https://doi.org/10.1016/S0006-291X(03)00627-2
- Rousset, S., Alves-Guerra, MC., Mozo, J., Miroux, B., Cassard- Doulcier, AM., Bouillaud, F. and Ricquier, D. : The biology of mitochondrial uncoupling proteins. Diabetes, 53 Suppl 1:S130-5 (2004) https://doi.org/10.2337/diabetes.53.2007.S130
- Langin, D. : The role of uncoupling protein 2 in the development of type 2 diabetes. Drugs Today (Barc), 39(4), 287-295 (2003) https://doi.org/10.1358/dot.2003.39.4.737960
- Susin, S.A., Lorenzo, H.K., Zamzami, N., Marzo, I., Brenner, C., Larochette, N., Prevost M.C., Alzari, P.M. and Kroemer, G. : Mitochondrial release of caspase-2 and -9 during the apoptotic process. J Exp Med, 189(2), 381-394 (1999) https://doi.org/10.1084/jem.189.2.381
- Luo, J.Z. and Luo, L. : American Ginseng Stimulates Insulin Production and Prevents Apoptosis through Regulation of Uncoupling Protein-2 in Cultured beta Cells. Evid Based Complement Alternat Med, 3(3), 365-372 (2006) https://doi.org/10.1093/ecam/nel026
- Wu, Z., Luo, J.Z. and Luo, L. : American ginseng modulates pancreatic beta cell activities Chinese Medicine, 25(2):11 (2007)
- Lim, I. S. : The Approach of Antioxidant , Endocrine, & Immune System on Exercise & Aging. Exercise science. 11(1):1226-1726 (2002)
- Hall, D.M., Sattler, G.L., Sattler, C.A., Zhang, H.J., Oberley, L.W., Pitot, H.C. and Kregel, K.C. : Aging lowers, steadyslate antioxidant enzyme and stress protein expression in primary (2001) https://doi.org/10.1093/gerona/56.6.B259
- Le Bourg, E. : Antioxidants as modulators. In: Rattan SIS (ed) Modulating Aging and Longevity. Biology of Aging and Its Modulation, 5, 183-203. (2003)
- Kim, Y.H., Park, K.H. and Rho, H.M. : Transcriptional activation of the Cu,Zn-superoxide dismutase gene through the AP2 site by ginsenoside Rb2 extracted from a medicinal plant, Panax ginseng. J Biol Chem. 4; 271(40), 24539-43 (1996) https://doi.org/10.1074/jbc.271.40.24539
- Black, R.A., Rauch, C.T., Kozlosky, C.J., Peschon, J.J., Slack, J.L., Wolfson, M.F., Castner, B.J., Stocking, K.L., Reddy, P., Srinivasan, S., Nelson, N., Boiani, N., Schooley, K.A., Gerhart, M., Davis, R., Fitzner, J.N., Johnson, R.S., Paxton, R.J., March, C.J. and Cerretti, D.P. : A metalloproteinase disintegrin that releases tumour necrosis factor-alpha from cells, Nature, 385, 729–733 (1997) https://doi.org/10.1038/385729a0
- Doedens, J.R. and Black, R.A. : Stimulation-induced downregulation of tumor necrosis factor-alpha converting enzyme, J. Biol. Chem. 275, 14598–14607 (2000) https://doi.org/10.1074/jbc.275.19.14598
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