Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Ginsenoside Rg1 Reduced Spontaneous Epileptiform Discharges and Behavioral Seizure in the Zebrafish

  • Lee, Yun-Kyoung (Department of Biological Sciences, College of Natural Sciences, Inha University) ;
  • Park, Eun-Jin (Department of Biological Sciences, College of Natural Sciences, Inha University) ;
  • Lee, Sang-Hun (Department of Biological Sciences, College of Natural Sciences, Inha University) ;
  • Kim, Yeon-Hwa (Department of Biological Sciences, College of Natural Sciences, Inha University) ;
  • Lee, Chang-Joong (Department of Biological Sciences, College of Natural Sciences, Inha University)
  • Published : 2009.03.31
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Abstract

Epileptifrom discharges were induced in the telencephalon of the adult zebrafish via perfusion with pentylenetetrazole (PTZ), bicuculline methiodide, kainic acid-treated artificial cerebrospinal fluid (aCSF), and $Mg^{2+}$-free aCSF. Ginseng total saponin [GTS ($50{\mu}g/ml$)] was shown to attenuate the occurrence rate of epilpetiform discharges by 50-75%, compared to the control. Ginsenoside $Rg_1$ ($130{\mu}M$) reduced the epileptiform discharges in the isolated telencephalon and delayed the occurrence of behavioral seizures observed from the adult zebrafish placed in the PTZ (10 mM)-containing aquarium water. However, Re was not effective in the suppression of epileptiform discharges and behavioral seizures. These results indicate that $Rg_1$ may be useful in the control of epileptiform discharges and effective in controlling behavioral seizures, and that the zebrafish can be used as a model animal for the testing of potential anticonvulsant drugs.

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References

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