The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Antidiabetic Effect of So-Dang-Hwan in Streptozotocin-induced Diabetic Rats

소당환이 Streptozotocin으로 유발된 흰쥐의 당뇨에 미치는 영향

  • Jung, Jin-Ki (Oriental Medicine Research Institute.Oriental Medicine R&D Center, Dongguk University) ;
  • Park, Yong-Ki (Oriental Medicine Research Institute.Oriental Medicine R&D Center, Dongguk University)
  • 정진기 (동국대학교 한의학연구소.한방신약개발센터) ;
  • 박용기 (동국대학교 한의학연구소.한방신약개발센터)
  • Published : 2009.03.30
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Abstract

Objectives : So-Dang-Hwan (SDH) is used as a traditional treatment of diabetes in oriental clinics in Korea. This study aimed to evaluate antidiabetic effect of SDH in streptozotocin (STZ)-induced diabetic rats. Methods : Diabetes was induced by i.p. injection of STZ (45 mg/kg) to Sprague-Dawley rats. Experimental animals (eight per group), were treated by oral administration of SDH (60 mg/kg body weight) and glibenclimide (1 mg/kg), a known antidiabetic drug for comparison, during 5 weeks. To veridy the effect of SDH, the levels of glucose, triglyceride, insulin, BUN and creatinine were measured in sera from experimental diabetic rats, and an oral glucose tolerance test (OGTT) was also performed. Results : SDH prevented body weight loss in diabetic rats. SDH exhibited at termination, a significant reduction in blood glucose levels in STZ-induced diabetic rats. SDH significantly reduced serum creatinine levels toward the normal levels. The OGTT results showed a significant improvement in glucose tolerance in rats treated with SDH. Conclusions : These data indicate that SDH treatment may improve glocose homeostasis in STZ-induced diabetes.

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References

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