Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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The Effect of Garlic and Medicinal Plants Extracts on the Liver Function and Lipid Metabolism of Rats Administered with Alcohol

마늘과 한약재 추출물의 혼합급이가 알코올 투여에 의한 간기능 및 지질대사에 미치는 영향

  • Lee, Soo-Jung (Dept. of Food Science and Nutrition, Institute of Agriculture and Life Scineces, Gyeongsang National University) ;
  • Kang, Min-Jung (Namhae Garlic Research Institute) ;
  • Shin, Jung-Hye (Namhae Garlic Research Institute) ;
  • Kim, Jeong-Gyun (Faculty of Marine Bioscience, Gyeongsang National University) ;
  • Kang, Shin-Kwon (Division of Food Science, International University of Korea) ;
  • Sung, Nak-Ju (Dept. of Food Science and Nutrition, Gyeongsang National University and Namhae Garlic Research Institute)
  • 이수정 (경상대학교 식품영양학과.농업생명과학연구원) ;
  • 강민정 ((재)남해마늘연구소) ;
  • 신정혜 ((재)남해마늘연구소) ;
  • 김정균 (경상대학교 해양생물이용학부) ;
  • 강신권 (한국국제대학교 식품과학부) ;
  • 성낙주 (경상대학교 식품영양학과.(재)남해마늘연구소)
  • Published : 2009.05.29
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Abstract

To investigate the effects of garlic and medicinal plants extracts (GP) on liver function and lipid metabolism of rat administered with ethanol chronically, Sprague-Dawly male rats were fed with a basial diet (Normal), a basial diet plus ethanol (Control, 10 mL of 20% ethanol/kg b.w/day), a control diet plus 0.5% garlic and 1.0% medicinal plants extracts (GP-I), and a control diet plus 1.0% garlic and medicinal plants extracts (GP-II) for 4 weeks. Blood glucose in GP group was significantly decreased, but not significantly different between GP-I and GP-II group. Albumin content of serum was significantly increased in GP groups, while total lipid, cholesterol and triglyceride of serum were significantly decreased in GP group. Total cholesterol and triglyceride were not significantly different between GP-I and GP-II group. LDL-cholesterol in blood was decreased to 58% in GP-I group and 73% in GP-II group compared to the control group, it's contents were the lowest amounts among the normal, control and experimented groups. Lipid levels in liver of rat administered with alcohol were decreased in GP group and significantly different in GP-II group. GOT and r-GTP activities were significantly higher in control than normal group, while GPT and ALP activities were not significant in groups administered with alcohol. Activities of GOT, GPT and r-GTP were significantly lower in GP group than control group, while ALP activity was not significant in all groups. TBARS contents were not significant in serum, but it's contents in liver were significantly decreased in GP groups than control group. DPPH radical scavenging ability in serum and liver was significantly increased in GP groups. These results indicate that garlic and medicinal plants extracts were effective in improving and protecting liver disorder induced from long-term alcohol consumption.

마늘과 한약재 추출물이 20% 알코올을 섭취한 흰쥐의 간기능 및 지질대사에 미치는 영향을 조사하였다. 실험군은 기본식이(Normal), 기본식이+알코올 투여(Control), 알코올투여+마늘 추출물 0.5%+한약재 추출물 1.0%(GP-I), 알코올투여+마늘 추출물 1.0%+한약재 추출물 1.0%(GP-II)로 하였다. 마늘과 한약재 추출물의 급이 시 혈당은 대조군에 비해 유의적으로 감소되었으나, 마늘 첨가량에 따른 유의차는 적었다. 알부민 함량은 마늘 첨가량에 따라 유의적으로 증가하였다. 혈청 중 총 지질, 총 콜레스테롤 및 중성지방 함량은 마늘과 한약재 추출물의 급이 시 유의적으로 감소하였으며, 총 콜레스테롤 및 중성지방 함량은 마늘의 첨가량에 따른 유의차가 없었다. LDL-콜레스테롤은 대조군에 비해 GP-I군에서는 약 58%, GP-II군에서는 73% 정도 감소되어, 혈중 지질 함량의 변화 중 가장 큰 폭으로 감소되었다. 간조직의 지질 함량 변화는 혈액과 비슷한 경향이었으며, GP-II군에서 유의적으로 감소되었다. 알코올 투여로 혈청 GOT 및 r-GTP 활성은 정상군에 비해 유의적으로 증가하였으나, GPT 및 ALP 활성은 유의차가 적었다. 마늘과 한약재 추출물의 급이로 GOT, GPT 및 r-GTP 활성은 유의적으로 감소되었으나, ALP 활성은 모든 실험군 간에 유의차가 없었다. 마늘과 한약재 추출물의 급이에 따른 TBARS 함량은 혈액에서 유의차가 없었으나, 간 조직에서는 마늘 첨가량에 따라 유의적으로 감소되었다. DPPH 라디칼 소거에 의한 항산화활성은 혈액 및 간 조직에서 마늘의 첨가량에 따라 유의적으로 증가하였다. 따라서 마늘과 한약재 추출물의 급이는 알코올성 간 기능 개선 및 예방에 효과적인 것으로 판단된다.

Keywords

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