Journal of the Korean Society of Physical Medicine (대한물리의학회지)

The Korean Society of Physical Medicine (대한물리의학회)
권호 표지

Influences of Cold and Thermal Therapy on ILs and VEGF Expression after Muscle Contusion in Rats

온냉치료가 근타박 유발 흰쥐의와 발현에 미치는 ILs와 VEGF 발현에 미치는 영향

  • Heo, Gwang-Ho (Physical Therapy, Department of Rehabilitation Science, Graduate School of Daegu University) ;
  • Bang, Hyun-Soo (Physical Therapy, Department of Rehabilitation Science, Graduate School of Daegu University) ;
  • Park, Soo-Jin (Physical Therapy, Department of Rehabilitation Science, Graduate School of Daegu University) ;
  • Ahn, Ji-Hyun (Physical Therapy, Department of Rehabilitation Science, Graduate School of Daegu University) ;
  • Lee, Hyun-Min (Neuroscience Laboratory, College of Rehabilitation Science, Daegu University) ;
  • Choen, Song-Hee (Neuroscience Laboratory, College of Rehabilitation Science, Daegu University) ;
  • Kim, Jin-Sang (Department of Physical Therapy, College of Rehabilitation Science, Daegu University)
  • 허광호 (대구대학교 대학원 재활과학과 물리치료) ;
  • 방현수 (대구대학교 대학원 재활과학과 물리치료) ;
  • 박수진 (대구대학교 대학원 재활과학과 물리치료) ;
  • 안지현 (대구대학교 대학원 재활과학과 물리치료) ;
  • 이현민 (대구대학교 재활과학대학 신경과학교실) ;
  • 천송희 (대구대학교 재활과학대학 신경과학교실) ;
  • 김진상 (대구대학교 재활과학대학 물리치료과)
  • Published : 2009.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose : The purpose of this study was to evaluate the effects of cold therapy and thermal therapy, and immunoreactivity of vascular endothelial growth factor(VEGF), Interleukin-1(IL-1) and Interleukin-6(IL-6) on angiogenesis after muscle contusion injury. Methods : Muscle contusion injury was induced in the gastronemius muscle by dropping a metal bead(22.8g). Cold and thermal theraphy was applied immediately and directly to the skin of injured muscle daily for three days. (experimental group-1 : $5^{\circ}$ cold pack, experimental group-2 : $50^{\circ}$ hot pack, control group non applied, treatment time : 10minutes) Results : The experimental group-1 and 2 showed higher immunoreactivity of VEGF, IL-1, IL-6 than control group during 3 days(P<0.05). And the experimental group-2 showed higher than the experimental group-1 especially VEGF(P<0.05). Conclusion : There data thermal therapy was more effective than cold therapy in the acute muscle contusion injury.

Keywords

References

  1. 강현숙, 관절염 환자의 증상완화를 위한 온요법과 냉요법의 비교연구. 근관절건강학회지. 1995;2(2):147-59
  2. 김근조, 이규리. 온. 냉적용시 신체부위별 및 시간에 따른 체온변화에 대한 연구. 대한물리치료과학회지. 1995;2(3)577-586.
  3. 김민규. 구예련, 김효 등. 냉과 거상이 피부온도에 미치는 영향. 한국전문물리치료학회지. 1996;3(1)48-56
  4. 김석범, 김진상. AaAIAs 레이저 조사가 근타박상이 유발된 흰쥐 골격근내 혈관내피성장인자 발현에 미치는 영향. 대한물리치료학회지. 2003;15(3):447-64
  5. 김재철, 이호근, 황평한 등. Retraining 에 따른 골격근내 VEGF protein의 발현 한국체육학회지. 2002;41(2):565-71.
  6. 민경옥. 온열 및 수치료학. 대학서림. 1992;125-30.
  7. 박승한, 배치헌, 임강일 등. 운동과 사우나시 혈액성분의 변화. 한국생활환경학회지. 1997;4(1):23-32.
  8. 박종철, 김상엽, 남기석 등. 수치료의 이론과 실제. 현문사. 2007;46-59.
  9. 이승주, 김상엽, 김현숙 등. 수치료학. 현문사 2005;3-67.
  10. 정우성, 김미정, 박시복 등. 냉기 치료에 따른 둔근에서의 피부 및 근육내 온도 변화. 대한재활의학회지. 1998;22(2):294-8.
  11. Amaral AC, Parizotto NA, Salvini TF. Dosedependency of low-energy HeNe laser effect in regeneration of skeletal muscle in mice. Lasers Med Sci. 2001;16(1):44-51. https://doi.org/10.1007/PL00011336
  12. Beiner JM, Jokl P. Muscle contusion injuries: current treatment options. J Am Acad Orthop Surg. 2001;9(4):227-37. https://doi.org/10.5435/00124635-200107000-00002
  13. Cannon JG, St.Pierre BA. Cytokines in exertioninduced skeletal muscle injury. Mol Cell Biochem. 1998;179:159-67. https://doi.org/10.1023/A:1006828425418
  14. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000;407:249-57. https://doi.org/10.1038/35025220
  15. Chambers RL, McDermott JC. Molecular basis of skeletal muscle regeneration. Can J Appl Physiol. 1996;21(3):155-84. https://doi.org/10.1139/h96-014
  16. Christodoulou C, Choy EH. Joint inflammation and cytokine inhibition in rheumatoid arthritis. Clin Exp Med. 2006;6(1):13-9. https://doi.org/10.1007/s10238-006-0088-5
  17. Conway EM, Collen D, Carmeliet P. Molecular mechanisms of blood vessle growth. Cardiovasc Res. 2001;49:507-21. https://doi.org/10.1016/S0008-6363(00)00281-9
  18. Endo F, Daichyo Y, Askawa Y et al. The effect of hot baths on blood components. Ann. Rep. Med. Care Technol. Gunma Univ. 1990;11(1):161-6.
  19. Ferrara N, Houck K, Jakeman L et al. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev. 1992;13(1):18-32. https://doi.org/10.1210/edrv-13-1-18
  20. Hockel M, Schlenger K, Doctrow S et al. Therapeutic angiogenesis, Arch Surg. 1993;128(4):423-9. https://doi.org/10.1001/archsurg.1993.01420160061009
  21. Husmann I, Soulet L, Gautron J et al. Growth factors in skeletal muscle regeneration. Cytokine Growth Factor Rev. 1996;7(3):249-58. https://doi.org/10.1016/S1359-6101(96)00029-9
  22. Kami K, Morikawa Y, Kawai Y et al. Leukemia inhibitory factor, glial cell line-derived neurotrophic factor, and their receptor expressions following muscle crush injury. Muscle Nerve. 1999;22(11): 1576-89. https://doi.org/10.1002/(SICI)1097-4598(199911)22:11<1576::AID-MUS14>3.0.CO;2-T
  23. Reher P, Doan N, Bradnock B et al. Effect of ultrasound on the production of IL-8, basic FGF and VEGF. Cytokine. 1999;11(4):416-23. https://doi.org/10.1006/cyto.1998.0444