Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Anti-Atherosclerosis Activity of Rosmarinic Acid in Human Aortic Smooth Muscle Cells

사람 동맥 평활근 세포에 대한 Rosmarinic Acid의 항동맥경화 활성

  • Ha, Jung-Jae (Department of Prescriptionology, Collage of Oriental Medicine, Dongguk University) ;
  • Yun, Hyun-Jeong (Cardiovascular Medical Research Center) ;
  • Huh, Joon-Young (Department of Prescriptionology, Collage of Oriental Medicine, Dongguk University) ;
  • Kim, Jai-Eun (Cardiovascular Medical Research Center) ;
  • Park, Sun-Dong (Cardiovascular Medical Research Center)
  • 정재하 (동국대학교 한의과대학 방제학교실) ;
  • 윤현정 (심혈관계질환 천연물 연구개발센터) ;
  • 허준영 (동국대학교 한의과대학 방제학교실) ;
  • 김재은 (심혈관계질환 천연물 연구개발센터) ;
  • 박선동 (심혈관계질환 천연물 연구개발센터)
  • Published : 2009.12.25
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Abstract

Rosmarinic acid frequently found as a secondary metabolite in herbs and medicinal plants, has exhibited antimicrobial, antiviral, antioxidative, and anti-inflammatory activities. The proliferation and migration of human aortic smooth muscle cells (HASMC) in response to activation by various stimuli plays a critical role in the initiation and development of atherosclerosis. This study was conducted to examine the effects of Rosmarinic acid on the proliferation and migration of HASMC. Rosmarinic acid suppressed the proliferation of HASMC via induction of the expression of apoptotic proteins including cleaved poly ADP-ribose polymerase (PARP), and caspase-3. Rosmarinic acid decreased anti-apoptotic Bcl-2 and increased pro-apoptotic Bax. Moreover, treatment of rosmarinic acid decreased the G1/S cycle regulation proteins (cyclin D1, cyclin E, CDK2, CDK4 and CDK6) and increased p21, p27 and p53. Rosmarinic acid also blocked HASMC migration via suppression of MMP-9 and MMP-2. Taken together, these results indicate that rosmarinic acid has the potential for use as an anti-atherosclerosis agent.

Keywords

References

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