Inhibitory effect of acupuncture at HT7 on the sympathetic activations to smoking-related visual cues during smoking cessation

금단기간 중 흡연관련 시각자극에 의한 교감신경 반응에 대한 신문혈 침자극의 억제 효과

  • Chae, Youn-Byoung (Acupuncture and Meridian Science Research Center (AMSRC), Kyung Hee University) ;
  • Lee, Jeong-Chan (Department of Biomedical Engineering, Kyung Hee University) ;
  • Park, Kyung-Mo (Department of Biomedical Engineering, Kyung Hee University) ;
  • Lee, Hye-Jung (Acupuncture and Meridian Science Research Center (AMSRC), Kyung Hee University) ;
  • Kang, O-Seok (Acupuncture and Meridian Science Research Center (AMSRC), Kyung Hee University) ;
  • Kim, Song-Yi (Acupuncture and Meridian Science Research Center (AMSRC), Kyung Hee University) ;
  • Lee, Hwa-Jin (Acupuncture and Meridian Science Research Center (AMSRC), Kyung Hee University) ;
  • Yin, Chang-Sik (Acupuncture and Meridian Science Research Center (AMSRC), Kyung Hee University) ;
  • Park, Hi-Joon (Acupuncture and Meridian Science Research Center (AMSRC), Kyung Hee University)
  • 채윤병 (경희대학교 침구경락과학연구센터) ;
  • 이정찬 (경희대학교 동서의료공학과) ;
  • 박경모 (경희대학교 동서의료공학과) ;
  • 이혜정 (경희대학교 침구경락과학연구센터) ;
  • 강오석 (경희대학교 침구경락과학연구센터) ;
  • 김송이 (경희대학교 침구경락과학연구센터) ;
  • 이화진 (경희대학교 침구경락과학연구센터) ;
  • 인창식 (경희대학교 침구경락과학연구센터) ;
  • 박히준 (경희대학교 침구경락과학연구센터)
  • Published : 2009.12.27

Abstract

Objectives : Cue reactivity is a key factor that modulates motivational goal-directed behavior associated with compulsive drug-taking and relapse. We investigated whether acupuncture attenuated the skin conductance response and the heart rate response to smoking-related visual cues in smokers. Methods : Twenty-nine smokers were treated with real acupuncture (RA) or sham acupuncture (SA). The stress response inventory was measured on the 5th day after quitting smoking. The skin conductance response and the heart rate were measured to evaluate the autonomic changes to the smoking related visual cues on the same day. Results : The sympathetic alterations in skin conductance and the heart rate induced by the smoking-related visual cues were significantly lower in the RA group, as compared to the SA group. The stress response inventory, such as somatization and frustration, in the RA group was significantly lower than that of the SA group. Conclusions : Acupuncture ameliorated the stress symptoms as well as the sympathetic activation to smoking cues during withdrawal. These findings indicate that acupuncture might be a useful tool in smoking cessation by inhibiting smoking cues-induced autonomic responses.

Keywords

References

  1. Law M, Tang JL. An analysis of the effectiveness of interventions intended to help people stop smoking. Arch Intern Med. 1995 ; 155(18) : 1933-41. https://doi.org/10.1001/archinte.155.18.1933
  2. al'Absi M, Hatsukami D, Davis GL, Wittmers LE. Prospective examination of effects of smoking abstinence on cortisol and withdrawal symptoms as predictors of early smoking relapse. Drug Alcohol Depend. 2004 ; 73(3) : 267-78. https://doi.org/10.1016/j.drugalcdep.2003.10.014
  3. White AR, Rampes H, Campbell JL. Acupuncture and related interventions for smoking cessation Cochrane Database Syst Rev, 25 (2006) CD000009.
  4. Chae Y, Yang CH, Kwon YK, Kim MR, Pyun KH, Hahm DH, et al. Acupuncture attenuates repeated nicotine-induced behavioral sensitization and c-Fos expression in the nucleus accumbens and striatum of the rat. Neurosci Lett. 2004 ; 358(2) : 87-90. https://doi.org/10.1016/j.neulet.2003.12.121
  5. Yoon SS, Kwon YK, Kim MR, Shim I, Kim KJ, Lee MH, et al. Acupuncture-mediated inhibition of ethanol-induced dopamine release in the rat nucleus accumbens through the GABAB receptor. Neurosci Lett. 2004 ; 369(3) : 234-8. https://doi.org/10.1016/j.neulet.2004.07.095
  6. Kim MR, Kim SJ, Lyu YS, Kim SH, Lee Y, Kim TH, et al. Effect of acupuncture on behavioral hyperactivity and dopamine release in the nucleus accumbens in rats sensitized to morphine. Neurosci Lett. 2005 ; 387(1) : 17-21. https://doi.org/10.1016/j.neulet.2005.07.007
  7. Moffet HH. How might acupuncture work? A systematic review of physiologic rationales from clinical trials. BMC Complement Altern Med. 2006 ; 6 : 25. https://doi.org/10.1186/1472-6882-6-25
  8. 채윤병, 박히준, 구성태, 이혜정. 침과 자율신경계 고찰: 인체의 심박변이도 중심으로. 경락경혈학회지. 2007 ; 24 : 25-36.
  9. Huang ST, Chen GY, Lo HM, Lin JG, Lee YS, Kuo CD. Increase in the vagal modulation by acupuncture at neiguan point in the healthy subjects. Am J Chin Med. 2005 ; 33(1) : 157-64. https://doi.org/10.1142/S0192415X0500276X
  10. Wang JD, Kuo TB, Yang CC. An alternative method to enhance vagal activities and suppress sympathetic activities in humans. Auton Neurosci. 2002 ; 100(1-2) : 90-5.
  11. Middlekauff HR, Hui K, Yu JL, Hamilton MA, Fonarow GC, Moriguchi J, et al. Acupuncture inhibits sympathetic activation during mental stress in advanced heart failure patients. J Card Fail. 2002 ; 8(6) : 399-406. https://doi.org/10.1054/jcaf.2002.129656
  12. Niaura RS, Rohsenow DJ, Binkoff JA, Monti PM, Pedraza M, Abrams DB. Relevance of cue reactivity to understanding alcohol and smoking relapse. J Abnorm Psychol. 1988 ; 97(2) : 133-52.
  13. Tiffany ST, Cox LS, Elash CA. Effects of transdermal nicotine patches on abstinence-induced and cue-elicited craving in cigarette smokers. J Consult Clin Psychol. 2000 ; 68(2) : 233-40.
  14. Park J, White A, Stevenson C, Ernst E, James M. Validating a new non-penetrating sham acupuncture device: two randomised controlled trials. Acupunct Med. 2002 ; 20 : 168-74. https://doi.org/10.1136/aim.20.4.168
  15. Koh KB, Park JK, Kim CH, Cho S. Development of the stress response inventory and its application in clinical practice. Psychosom Med. 2001 ; 63(4) : 668-78.
  16. Bradley MM, Lang PJ. Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. J Behav Ther Exp Psychiatry. 1994 ; 25(1) : 49-59. https://doi.org/10.1016/0005-7916(94)90063-9
  17. 이경화, 이임갑, 손진훈. 정서의 심리적 생리적 측정 및 지표개발: 기본 정서구분모델. 한국감성과학회지. 1999 ; 2(2) : 43-52.
  18. Fuller JA. Smoking withdrawal and acupuncture. Med J Aust. 1982 ; 1(1) : 28-9.
  19. Waite NR, Clough JB. A single-blind, placebo-controlled trial of a simple acupuncture treatment in the cessation of smoking. Br J Gen Pract. 1998 ; 48(433) : 1487-90.
  20. Bradley MM, Cuthbert BN, Lang PJ. Pictures as prepulse: attention and emotion in startle modification. Psychophysiology. 1993 ; 30(5) : 541-5. https://doi.org/10.1111/j.1469-8986.1993.tb02079.x
  21. Saumet JL, Dittmar A. Heat loss and anticipatory finger vasoconstriction induced by a smoking of a single cigarette. Physiol Behav. 1985 ; 35(2) : 229-32. https://doi.org/10.1016/0031-9384(85)90341-5
  22. Niaura R, Abrams D, Demuth B, Pinto R, Monti P. Responses to smoking-related stimuli and early relapse to smoking. Addict Behav. 1989 ; 14(4) : 419-28. https://doi.org/10.1016/0306-4603(89)90029-4
  23. Chae Y, Lee JC, Park KM, Kang OS, Park HJ, Lee H. Subjective and autonomic responses to smoking-related visual cues. J Physiol Sci. 2008 ; 58(2) : 139-45. https://doi.org/10.2170/physiolsci.RP014207
  24. Kalman D. The subjective effects of nicotine: methodological issues, a review of experimental studies, and recommendations for future research. Nicotine Tob Res. 2002 ; 4(1) : 25-70.
  25. Chae Y, Yeom M, Han JH, Park HJ, Hahm DH, Shim I, et al. Effect of acupuncture on anxiety-like behavior during nicotine withdrawal and relevant mechanisms. Neurosci Lett. 2008 ; 430(2) : 98-102. https://doi.org/10.1016/j.neulet.2007.10.026
  26. Mendelson G. Acupuncture and cholinergic suppression of the withdrawal symptoms: an hypothesis. Br J Addiction. 1978 ; 73 : 166-70. https://doi.org/10.1111/j.1360-0443.1978.tb00137.x
  27. White A, Moody R. The effects of auricular acupuncture on smoking cessation may not depend on the point chosen-an exploratory meta-analysis. Acupunct Med. 2006 ; 24(4) : 149-56. https://doi.org/10.1136/aim.24.4.149
  28. Park HJ, Chae Y, Jang J, Shim I, Lee H, Lim S. The effect of acupuncture on anxiety and neuropeptide Y expression in the basolateral amygdala of maternally separated rats. Neurosci Lett. 2005 ; 377(3) : 179-84. https://doi.org/10.1016/j.neulet.2004.11.097
  29. Zhao RJ, Yoon SS, Lee BH, Kwon YK, Kim KJ, Shim I, et al. Acupuncture normalizes the release of accumbal dopamine during the withdrawal period and after the ethanol challenge in chronic ethanol-treated rats. Neurosci Lett. 2006 ; 395(1) : 28-32. https://doi.org/10.1016/j.neulet.2005.10.043
  30. Jiang A, Cui M. Analysis of therapeutic effects of acupuncture on abstinence from smoking. J Tradit Chin Med. 1994 ; 14(1) : 56-63.
  31. Bang H, Ni L, Davis CE. Assessment of blinding in clinical trials. Control Clin Trials. 2004 ; 25(2) : 143-56. https://doi.org/10.1016/j.cct.2003.10.016