생약학회지 (Korean Journal of Pharmacognosy)

  • 제40권4호
  • /
  • Pages.345-350
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  • 2009
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

도깨비바늘 꽃 성분의 항산화 및 간보호 효과

Antioxidative and Hepatoprotective Effect of Compounds from the Flowers of Bidens bipinnata L.

  • 권지웅 (원광대학교 생명자원과학대학) ;
  • 변에리사 (원광대학교 약학대학) ;
  • 이어진 (원광대학교 생명자원과학대학) ;
  • 김윤철 (원광대학교 약학대학) ;
  • 정길생 (원광대학교 인수공통감염병 연구센터) ;
  • 안인파 (중국 연변대학 장백산생물자원 및 공능분자교육부중점실험실) ;
  • 권태오 (원광대학교 생명자원과학대학)
  • Kwon, Ji-Wung (College of Life Science and Natural Resources, Wonkwang University) ;
  • Byun, Erisa (College of Pharmacy, Wonkwang University) ;
  • Lee, Eoh-Jin (College of Life Science and Natural Resources, Wonkwang University) ;
  • Kim, Youn-Chul (College of Pharmacy, Wonkwang University) ;
  • Jeong, Gil-Saeng (Zoonosis Research Center, Wonkwang University) ;
  • An, Ren-Bo (Key Laboratory of Natural Resources of Changbai Mountain & Funcional Molecules (Yanbian University) Ministry of Education) ;
  • Kwon, Tae-Oh (College of Life Science and Natural Resources, Wonkwang University)
  • 발행 : 2009.12.31
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초록

Activity-guided fractionation of the EtOH extract of flowers of Bidens bipinnata L. have been furnished five flavonoids, sulfuretin(1), butein(2), 7,8,3',4'-tetrahydroxyflavanone(3), maritimetin(4) and okanin(5). All of the compounds showed significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect. The evaluation for protective effect of isolated compounds against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells was conducted. Compounds 1, 3, 4 and 5 showed significant protective effects with the $EC_{50}$ values of $36.1{\pm}0.9$, $23.3{\pm}0.7$, $41.0{\pm}1.0$ and $29.8{\pm}1.1{\mu}M$, respectively. Silybin, one of the well-known hepatoprotective agents, used as a positive control, and also showed protective effect with an $EC_{50}$ value of $84.3{\pm}0.7{\mu}M$.

키워드

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