Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Analysis of Residual Furan in Human Blood Using Solid Phase Microextraction-Gas Chromatography/Mass Spectrometry (SPME-GC/MS)

  • Lee, Yun-Kyung (Department of Food Science and Technology, Dongguk University) ;
  • Jung, Seung-Won (Department of Food Science and Technology, Dongguk University) ;
  • Lee, Sung-Joon (Division of Food Science, College of Life Science and Biotechnology, Institute of Biomedical Sciences and Safety, Korea University) ;
  • Lee, Kwang-Geun (Department of Food Science and Technology, Dongguk University)
  • Published : 2009.04.30
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Abstract

For an accurate risk assessment of furan, a potential human carcinogen, levels must be determined in human blood plasma using a simple and robust assay. In this study, solid phase microextraction-gas chromatography/mass spectrometry (SPME-GC/MS) was used to analyze blood plasma levels of furan in 100 healthy individuals who consumed a normal diet. The subjects were 30 to 70 years of age and 51% were women. Ultimately, an analytical method was established for analyzing furan in human blood. The limit of quantification (LOQ) and furan recovery rate in blood were 1.0 ppb and 104%, respectively. Finally, furan was detected in 21 individuals (13 males, 8 females) with levels ranging up to 17.86 ppb (ng furan/g food).

Keywords

References

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