Food Science and Preservation (한국식품저장유통학회지)

The Korean Society of Food Preservation (한국식품저장유통학회)
권호 표지

Anti-Immunomodulating Activities in Mycelial Filtrates and Culture Broth of Cordyceps ochraceostromat

동충하초의 균사 및 배양액에 의한 면역 활성 비교

  • Heo, Jin-Chul (Food & Bio-Industry Research Institute and Department of Food Science & Technology, Kyungpook National University) ;
  • Nam, Sung-Hee (Department of Agricutural Biology, National Advanced Institute of Science & Technology, RDA) ;
  • Lee, Kwang-Gil (Department of Agricutural Biology, National Advanced Institute of Science & Technology, RDA) ;
  • Yeo, Joo-Hong (Department of Agricutural Biology, National Advanced Institute of Science & Technology, RDA) ;
  • Yoon, Chul-Sik (Mycoplus Co., Ltd.) ;
  • Park, Chul-Hong (Food & Bio-Industry Research Institute and Department of Food Science & Technology, Kyungpook National University) ;
  • Nam, So-Hyun (Food & Bio-Industry Research Institute and Department of Food Science & Technology, Kyungpook National University) ;
  • Son, Min-Sik (Food & Bio-Industry Research Institute and Department of Food Science & Technology, Kyungpook National University) ;
  • Chung, Shin-Kyo (Food & Bio-Industry Research Institute and Department of Food Science & Technology, Kyungpook National University) ;
  • Lee, Sang-Han (Food & Bio-Industry Research Institute and Department of Food Science & Technology, Kyungpook National University)
  • 허진철 (경북대학교 식품생물산업연구소 및 식품공학과) ;
  • 남성희 (국립농업과학원 농업생물부) ;
  • 이광길 (국립농업과학원 농업생물부) ;
  • 여주홍 (국립농업과학원 농업생물부) ;
  • 윤철식 (마이코플러스) ;
  • 박철홍 (경북대학교 식품생물산업연구소 및 식품공학과) ;
  • 남소현 (경북대학교 식품생물산업연구소 및 식품공학과) ;
  • 손민식 (경북대학교 식품생물산업연구소 및 식품공학과) ;
  • 정신교 (경북대학교 식품생물산업연구소 및 식품공학과) ;
  • 이상한 (경북대학교 식품생물산업연구소 및 식품공학과)
  • Published : 2009.04.30
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Abstract

This study investigated the effects of mycelium and culture supernatant of Cordyceps ochraceostromat(Co) on air way hyper-responsiveness, pulmonary immune cell infiltration, and Th2 cytokine expression in animal models of atopy and asthma. After ConA(+/-) activation of mouse primary spleen cells, decreased IL-4 and IL-13 cytokine production were seen in the presence of Co mycelium extracts and culture supernatant. The asthma model involved mice sensitized to ovalbumin by i.p. injection treatment; Co mycelium extract was also injected. The atopy model was the dinitrofenylbenzene-treated mouse ear. Ear thicken ing induced by DNFB was decreased by Co mycelium extract, and the extract also inhibited lung cell infiltration in ovalbumin-induced asthmatic mice. The results thus indicated that the Co mycelial extract reduced the undesirable immune responses seen in asthma and atopy.

Keywords

References

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