DOI QR코드

DOI QR Code

Hepatoprotective and Curative Properties of Kombucha Tea Against Carbon Tetrachloride-Induced Toxicity

  • Murugesan, G.S. (Microbial Biotechnology Division, Department of Biotechnology, Bharathiar University) ;
  • Sathishkumar, M. (Division of Biotechnology, Department of Food Science and Technology, Institute of Agricultural Science and Technology, Chonbuk National University) ;
  • Jayabalan, R. (Microbial Biotechnology Division, Department of Biotechnology, Bharathiar University) ;
  • Binupriya, A.R. (Division of Biotechnology, Department of Food Science and Technology, Institute of Agricultural Science and Technology, Chonbuk National University) ;
  • Swaminathan, K. (Microbial Biotechnology Division, Department of Biotechnology, Bharathiar University) ;
  • Yun, S.E. (Division of Biotechnology, Department of Food Science and Technology, Institute of Agricultural Science and Technology, Chonbuk National University)
  • 발행 : 2009.04.30

초록

Kombucha tea(KT) is sugared black tea fermented with a symbiotic culture of acetic acid bacteria and yeasts, which is said to be tea fungus. KT is claimed to have various beneficial effects on human health, but there is very little scientific evidence available in the literature. In the present study, KT along with black tea(BT) and black tea manufactured with tea fungus enzymes(enzyme-processed tea, ET) were evaluated for hepatoprotective and curative properties against $CCl_4$-induced toxicity, using male albino rats as an experimental model by analyzing aspartate transaminase, alanine transaminase, and alkaline phosphatase in plasma and malondialdehyde content in plasma and liver tissues. Histopathological analysis of liver tissue was also included. Results showed that BT, ET, and KT have the potential to revert the $CCl_4$-induced hepatotoxicity. Among the three types of teas tried, KT was found to be more efficient than BT and ET. Antioxidant molecules produced during the fermentation period could be the reason for the efficient hepatoprotective and curative properties of KT against $CCl_4$-induced hepatotoxicity.

키워드

참고문헌

  1. Blanc, P. J. 1996. Characterization of tea fungus metabolites. Biotechnol. Lett. 18: 139-142 https://doi.org/10.1007/BF00128667
  2. Brent, J. A. and B. H. Rumack. 1993. Role of free radicals in toxic hepatic injury. Clin. Toxicol. 31: 173-196 https://doi.org/10.3109/15563659309000384
  3. Cancalon, P. F. and M. E. Parish. 1995. Changes in the chemical compositions of orange juice during growth of Saccharomyces cerevisiae and Gluconobacter oxydans. Food Microbiol. 12: 117-124 https://doi.org/10.1016/S0740-0020(95)80087-5
  4. Chen, C. and B. Y. Liu. 2000. Changes in major components of tea fungus metabolites during prolonged fermentation. J. Appl. Microbiol. 89: 834-839 https://doi.org/10.1046/j.1365-2672.2000.01188.x
  5. Chu, S. C. and C. Chen. 2006. Effect of origins and fermentation time on the antioxidant activities of Kombucha. Food Chem. 98: 502-507 https://doi.org/10.1016/j.foodchem.2005.05.080
  6. CPSCEA guidelines for laboratory animal facility. 2003. Indian J. Pharmacol. 35: 257-274
  7. Duncan, D. B. 1955. Multiple range "F" tests. Biometrics 11: 1-42 https://doi.org/10.2307/3001478
  8. Elhalwagy, M. E. A., N. S. Darwish, and E. M. Zaher. 2008. Prophylactic effect of green tea polyphenols against liver and kidney injury induced by fenitrothion insecticide. Pesticide Biochem. Physiol. 91: 81-89 https://doi.org/10.1016/j.pestbp.2008.01.006
  9. Fadhel, Z. A. and S. Amran. 2002. Effects of black tea extract on carbon tetrachloride induced lipid peroxidation in liver, kidneys and testes of rats. Phytother. Res. 16: S28-S32
  10. Glenn, J. K., M. A. Morgan, M. B. Mayfield, M. Kuwahara, and M. H. Gold. 1983. An extracellular $H_2O_2$ requiring enzyme preparation involved in lignin biodegradation by the white rot basidiomycete. Biochem. Biophys. Res. Commun. 114: 1077- 1083 https://doi.org/10.1016/0006-291X(83)90672-1
  11. Gong, Y., C. Han, and J. Chen. 2000. Effect of tea polyphenols and tea pigments on the inhibition of precancerous liver lesions in rats. Nutr. Cancer 38: 81-86 https://doi.org/10.1207/S15327914NC381_12
  12. He, P., Y. Noda, and K. Sugiyama. 2001. Green tea suppresses lipopolysaccharide-induced liver injury in D-galactosaminesensitized rats. J. Nutr. 131: 1560-1567 https://doi.org/10.1093/jn/131.5.1560
  13. Hesseltine, C. W. 1965. A millenium of fungi, food and fermentation. Mycologia 5: 149-197
  14. Humason, G. L. 1979. Animal Tissue Techniques, 4th Ed. Freeman, San Fransisco, CA
  15. Jadon, A., M. Bhadauria, and S. Shukla. 2007. Protective effect of Terminalia belerica Roxb. and gallic acid against carbon tetrachloride induced damage in albino rats. J. Ethnopharmol. 109: 214-218 https://doi.org/10.1016/j.jep.2006.07.033
  16. Jain, A., M. S. L. Deb, A. Jain, S. P. Rout, V. B. Gupta, and K. L. Krishna. 2008. Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica oxb. leaves. J. Ethnopharmacol. 115: 61-66 https://doi.org/10.1016/j.jep.2007.09.009
  17. Jayabalan, R., S. Marimuthu, and K. Swaminathan. 2007. Changes in content of organic acids and tea polyphenols during Kombucha fermentation. Food Chem. 102: 392-398 https://doi.org/10.1016/j.foodchem.2006.05.032
  18. Jeon, T. I., S. G. Hwang, N. G. Park, Y. R. Jung, S. I. Shin, S. D. Choi, and D. K. Park. 2003. Antioxidative effect of chitosan on chronic carbon tetrachloride induced hepatic injury in rats. Toxicology 187: 67-73 https://doi.org/10.1016/S0300-483X(03)00003-9
  19. King, E. and A. R. Armstong. 1934. Determination of serum and bile phosphastase activity. Can. Med. Assoc. J. 31: 376- 378
  20. Kumaravelu, P., D. P. Dakshinamoorthy, S. Subramaniam, H. Devaraj, and N. S. Devaraj. 1995. Effect of eugenol on drugmetabolizing enzymes of carbon tetrachloride-intoxicated rat liver. Biochem. Pharmacol. 49: 1703-1707 https://doi.org/10.1016/0006-2952(95)00083-C
  21. Lee, H. S., H. H. Kim, and S. K. Ku. 2008. Hepatoprotective effects of Artemisiae capillaris Herba and Picrorrhiza rhizoma combinations on carbon tetrachloride-induced subacute liver damage in rats. Nutr. Res. 28: 270-277 https://doi.org/10.1016/j.nutres.2008.02.001
  22. Lin, H. M., H. C. Tseng, C. J. Wang, J. J. Lin, C. W. Lo, and F. P. Chou. 2008. Hepatoprotective effects of Solanum nigrum Linn extract against $CCl_4$-induced oxidative damage in rats. Chem. Biol. Inter. 171: 283-293 https://doi.org/10.1016/j.cbi.2007.08.008
  23. Nevin, K. G. and P. L. Vijayammal. 2005. Effect of Aerva lanata against hepatotoxicity of carbon tetrachloride in rats. Environ. Toxicol. Pharmacol. 20: 471-477 https://doi.org/10.1016/j.etap.2005.05.010
  24. Nichans, W. G. and B. Samuelson. 1968. Formation of MDA from phospholipid arachidonate during microsomal lipid peroxidation. Eur. J. Biochem. 6: 126-130 https://doi.org/10.1111/j.1432-1033.1968.tb00428.x
  25. Pauline, T., P. Dipti, B. Anju, S. Kavimani, S. K. Sharma, A. K. Kain, et al. 2001. Studies on toxicity, anti-stress and hepatoprotective properties of Kombucha tea. Biomed. Environ. Sci. 14: 207-213
  26. Reitman, S. and S. A. Frankel, 1957. Colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol. 28: 56 https://doi.org/10.1093/ajcp/28.1.56
  27. Sai Ram, M., B. Anju, T. Pauline, P. Dipti, A. K. Kain, S. S. Mongia, et al. 2000. Effect of Kombucha tea on chromate(VI)- induced oxidative stress in albino rats. J. Ethnopharmacol. 71: 235-240 https://doi.org/10.1016/S0378-8741(00)00161-6
  28. Yang, Y. S., T. H. Ahn, J. C. Lee, C. J. Moon, and S. H. Kim, 2008. Protective effects of pycnogenol on carbon tetrachlorideinduced hepatotoxicity in Sprague-Dawley rats. Food Chem. Toxicol. 46: 380-387 https://doi.org/10.1016/j.fct.2007.08.016
  29. Zhen, M. C., Q. Wang, X. H. Huang, L. Q. Cao, X. L. Chen, K. Sun, Y. J. Liu, W. Li, and L. J. Zhang. 2007. Green tea polyphenol epigallocatechin-3-gallate inhibits oxidative damage and preventive effects on carbon tetrachloride-induced hepatic fibrosis. J. Nutr. Biochem. 18: 795-805 https://doi.org/10.1016/j.jnutbio.2006.12.016

피인용 문헌

  1. Trypanocidal activity and acute toxicity assessment of triterpene acids vol.106, pp.4, 2009, https://doi.org/10.1007/s00436-010-1740-2
  2. Hepatoprotective properties of kombucha tea against TBHP-induced oxidative stress via suppression of mitochondria dependent apoptosis vol.18, pp.3, 2009, https://doi.org/10.1016/j.pathophys.2011.02.001
  3. Hepatoprotective activity of Livshis, a polyherbal formulation in CCl4-induced hepatotoxic male Wistar rats: A toxicity screening approach vol.3, pp.3, 2009, https://doi.org/10.1016/j.gmbhs.2012.03.001
  4. Protective effect of kombucha tea against acetaminophen-induced hepatotoxicity in mice: a biochemical and histopathological study vol.21, pp.6, 2009, https://doi.org/10.1007/s00580-011-1273-9
  5. CCl 4 -induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat vol.12, pp.None, 2009, https://doi.org/10.1186/1472-6882-12-178
  6. Hypoglycemic and antilipidemic properties of kombucha tea in alloxan-induced diabetic rats vol.12, pp.None, 2009, https://doi.org/10.1186/1472-6882-12-63
  7. Hepatoprotective effects of kombucha tea: identification of functional strains and?quantification of functional components vol.94, pp.2, 2009, https://doi.org/10.1002/jsfa.6245
  8. Current Evidence on Physiological Activity and Expected Health Effects of Kombucha Fermented Beverage vol.17, pp.2, 2009, https://doi.org/10.1089/jmf.2013.0031
  9. CCl 4 induced genotoxicity and DNA oxidative damages in rats: hepatoprotective effect of Sonchus arvensis vol.14, pp.None, 2009, https://doi.org/10.1186/1472-6882-14-452
  10. A Toxic Hepatitis Caused the Kombucha Tea – Case Report vol.2, pp.1, 2009, https://doi.org/10.3889/oamjms.2014.023
  11. Health, Wellness, and Safety Aspects of the Consumption of Kombucha vol.2015, pp.None, 2015, https://doi.org/10.1155/2015/591869
  12. Protective effect of kombucha on rats fed a hypercholesterolemic diet is mediated by its antioxidant activity vol.53, pp.11, 2009, https://doi.org/10.3109/13880209.2014.1001408
  13. Kombucha tea ameliorates experimental autoimmune encephalomyelitis in mouse model of multiple sclerosis vol.26, pp.6, 2015, https://doi.org/10.1080/09540105.2015.1036353
  14. Anti-foot-and-mouth disease virus effects of Chinese herbal kombucha in vivo vol.46, pp.4, 2009, https://doi.org/10.1590/s1517-838246420140701
  15. Kombucha tea prevents obese mice from developing hepatic steatosis and liver damage vol.25, pp.3, 2009, https://doi.org/10.1007/s10068-016-0142-3
  16. Crataegus songaricamethanolic extract accelerates enzymatic status in kidney and heart tissue damage in albino rats and itsin vitrocytotoxic activity vol.54, pp.7, 2009, https://doi.org/10.3109/13880209.2015.1066398
  17. 감귤과 녹차의 추출액으로 제조한 콤부차의 생리 활성 및 일반 세포 독성 vol.45, pp.12, 2009, https://doi.org/10.3746/jkfn.2016.45.12.1838
  18. Influence of different sugar sources, nitrogen sources and inocula on the quality characteristics of apple tea wine : Quality characteristics of apple tea wine vol.123, pp.2, 2017, https://doi.org/10.1002/jib.417
  19. Traditional low-alcoholic and non-alcoholic fermented beverages consumed in European countries: a neglected food group vol.30, pp.1, 2009, https://doi.org/10.1017/s0954422416000202
  20. Hepatoprotective effect of the solvent extracts of Viola canescens Wall. ex. Roxb. against CCl 4 induced toxicity through antioxidant and membrane stabilizing activity vol.17, pp.None, 2009, https://doi.org/10.1186/s12906-016-1537-7
  21. Harnessing the Power of Microbiome Assessment Tools as Part of Neuroprotective Nutrition and Lifestyle Medicine Interventions vol.6, pp.2, 2018, https://doi.org/10.3390/microorganisms6020035
  22. The Compositional and Functional Properties of Kombucha: A Literature Review vol.24, pp.1, 2009, https://doi.org/10.13050/foodengprog.2020.24.1.1
  23. Microbiological and technological parameters impacting the chemical composition and sensory quality of kombucha vol.19, pp.4, 2009, https://doi.org/10.1111/1541-4337.12574
  24. The protective effect of Kombucha against silver nanoparticles‐induced toxicity on testicular tissue in NMRI mice vol.53, pp.3, 2009, https://doi.org/10.1111/and.13982
  25. Ethanol Concentration of Kombucha Teas in British Columbia, Canada vol.84, pp.11, 2009, https://doi.org/10.4315/jfp-21-130
  26. Health effects and probiotic and prebiotic potential of Kombucha: A bibliometric and systematic review vol.44, pp.no.pa, 2009, https://doi.org/10.1016/j.fbio.2021.101332