Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Compositae Plants on Plasma Glucose and Lipid Level in Streptozotocin Induced Diabetic Rats

국화과 식물의 섭취가 Streptozotocin 유발 당뇨 흰쥐의 혈당과 지질 수준에 미치는 영향

  • Han, Hye-Kyoung (Plant Resources Research Institute, Duksung Women's University) ;
  • Yoon, Su-Jin (Dept. of Food and Nutrition, Duksung Women's University) ;
  • Kim, Gun-Hee (Plant Resources Research Institute, Duksung Women's University)
  • 한혜경 (덕성여자대학교 식물자원연구소) ;
  • 윤수진 (덕성여자대학교 식품영양학과) ;
  • 김건희 (덕성여자대학교 식물자원연구소)
  • Published : 2009.06.30
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Abstract

This study was designed to examine the effects of Compositae plants on plasma glucose and lipid levels in streptozotocin (STZ) induced diabetic rats. Sprague-Dawley rats were randomly assigned to 5 groups: normal, STZ-control and three experimental groups [Artemisia iwayomogi (A. iwayomogi), Atractylodes lancea (A. lancea), and Taraxacum mongolicum (T. mongolicum)]. Normal and STZ-control group were fed an AIN-93 diet and three experimental groups were each fed a modified diet containing 10% compositae powder for 4 weeks. The plasma glucose levels at 4 weeks of A. iwayomogi, A. lancea, and T. mongolicum groups were significantly lower than STZ-control group. The A. iwayomogi and A. lancea groups had significantly suppressed hypertrophy of liver and kidney. The hematocrit levels of A. lancea and T. mongolicum group were significantly lower than STZ-control groups. The total cholesterol and triglyceride levels and atherogenic index (AI) of A. lancea group were significantly lower than STZ-control group. Intake of Compositae plants may be effective in antihyperglycemia by lowering blood glucose levels. The A. iwayomogi, A. lancea, and T. mongolicum can be beneficial for the diabetic complications and damage from the lipid peroxidation.

국화과(Compositae) 식물 중 인진, 창출 및 민들레 분말이 STZ 유발 당뇨 흰쥐의 혈당 및 혈장 지질 상태에 미치는 영향을 구명하기 위하여 Sprague-Dawley계 흰쥐에게 국화과 식물 분말이 함유된 식이를 4주간 섭취시켜 다음과 같은 결과를 얻었다. 실험 4주 후 체중증가량은 당뇨대조군에 비해 인진섭취군의 경우 유의적인 차이를 보이지는 않았지만 증가하였다. 평균 식이섭취량은 당뇨대조군에 비해 모든 당뇨실험군에서 감소하였으며, 창출섭취군과 민들레섭취군에서 유의적으로 감소하였다. 식이효율은 인진섭취군의 경우 유의적 차이는 없지만 가장 높은 식이효율을 나타내었다. 혈장 포도당 함량을 측정한 결과 당뇨대조군은 고혈당이 지속된 반면 실험 2주째에는 당뇨대조군보다 인진섭취군과 민들레섭취군, 실험 3주째에는 인진섭취군, 실험 4주째에는 인진섭취군과 민들레섭취군이 당뇨대조군보다 유의적으로 낮은 혈당 수준을 보였다. 창출섭취군에서는 실험 1주째부터 실험 4주째까지 당뇨대조군에 비해 유의적인 혈당 감소를 보여 국화과 식물의 섭취가 모두 혈당 상승 억제 효과가 있었다. 간장 글리코겐 함량은 인진섭취군, 창출섭취군 및 민들레섭취군의 모든 당뇨실험군에서 유의적인 차이는 없었으나 당뇨대조군보다 높은 수치를 나타내었다. 근육 글리코겐 함량도 인진섭취군에서 유의적이지는 않지만 당뇨대조군에 비해 높은 수치를 나타내었다. 장기의 무게를 체중 100g당으로 환산하였을 때 간장과 신장의 경우 인진섭취군, 창출섭취군 및 민들레섭취군의 무게가 당뇨대조군보다 유의적으로 낮은 것으로 나타나 간장과 신장의 비대를 억제한 것으로 나타났다. 폐의 경우 민들레섭취군이 당뇨대조군에 비해 낮은 무게를 나타냈다. 췌장, 비장 및 뇌의 경우 창출섭취군이 당뇨대조군에 비해 유의적으로 높은 무게를 나타내어 손상을 억제한 것으로 나타났다. 헤마토크릿치는 창출섭취군과 민들레섭취군에서 당뇨대조군에 비해 유의적으로 낮은 수준을 나타내었다. 인진섭취군의 경우 ALT 활성도는 유의적 차이를 보이지는 않았지만 당뇨대조군보다 낮은 활성도를 나타내어 간과 신장의 손상이 적음을 알 수 있었다. 실험 4주 후 혈장의 지질 함량을 측정한 결과 총콜레스테롤, 중성지방 및 유리지방산 함량이 창출섭취군에서 당뇨대조군에 비해 유의적으로 감소하였다. HDL-콜레스테롤 함량은 유의적인 차이는 보이지 않았으나 인진섭취군과 민들레섭취군에서 효과가 있는 것으로 나타났다. 이상의 실험결과 인진, 창출 및 민들레의 국화과식물의 섭취가 STZ으로 유발된 당뇨쥐의 혈당을 유의적으로 감소시켰으며, 창출의 섭취가 지질대사 이상 중 증가된 혈중 중성지방과 유리지방산을 유의적으로 감소시켰으므로 당뇨 시 혈당조절과 고지혈증 개선에 유익할 것으로 사료된다.

Keywords

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  16. 도라지 뿌리 에탄올 추출물이 streptozotocin으로 유발된 흰쥐의 혈당지질, 당대사에 미치는 영향 vol.33, pp.4, 2009, https://doi.org/10.12925/jkocs.2016.33.4.686
  17. Streptozotocin으로 유발된 당뇨쥐에서 맥문동 에탄올 추출물의 당뇨개선효과 vol.34, pp.2, 2009, https://doi.org/10.12925/jkocs.2017.34.2.254
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