Korean Journal of Microbiology (미생물학회지)

The Microbiological Society of Korea (한국미생물학회)
권호 표지

Antimicrobial Resistance and Multidrug Resistance Patterns of Salmonella enterica serovar Enteritidis Isolated from Diarrhea Patients, Incheon

인천지역 설사환자에서 분리한 Salmonella enterica serovar Enteritidis의 항생제 내성 및 다제내성 양상

  • 황경화 (인천광역시보건환경연구원 질병조사과) ;
  • 오보영 (인천광역시보건환경연구원 질병조사과) ;
  • 김정희 (인천광역시보건환경연구원 질병조사과) ;
  • 김명희 (인천광역시보건환경연구원 질병조사과) ;
  • 제갈승 (인천광역시보건환경연구원 질병조사과) ;
  • 이은주 (인천광역시보건환경연구원 질병조사과) ;
  • 이은정 (인천광역시보건환경연구원 질병조사과) ;
  • 조남규 (인천광역시보건환경연구원 질병조사과) ;
  • 고종명 (인천광역시보건환경연구원 질병조사과) ;
  • 김용희 (인천광역시보건환경연구원 질병조사과)
  • Received : 2009.04.27
  • Accepted : 2009.06.08
  • Published : 2009.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

This study describes the antimicrobial susceptibility and multidrug resistance patterns in 115 isolates of Salmonella enterica serovar Enteritidis from diarrhea patients in Incheon from Jan. 2004 to Dec. 2008. Overall, the highest rate of resistance was found to the following antimicrobial agents: nalidixic acid 54.8%, ampicillin 40.0%, ticarcillin 38.3%, chloramphenicol 20.9%, and tetracycline 17.4%. 91% (104 isolates) were resistant to one or more antimicrobial agents tested. Among the described antimicrobial resistant patterns, the predominant patterns were only nalidixic acid (44.3%), ampicillin-chloramphenicol-ticarcillin (11.3%,) and ampicillin-ticarcillin (10.4%). Overall, the resistant rate to one drug was 51.9%, two drugs 18.2%, three drugs 14.5%, four drugs 5.8%, and five or more drugs 9.7%.

본 연구에서는 2004년 1월부터 2008년 12월까지 인천지역 5개 종합 병 의원에 설사증상으로 입원 또는 내원한 환자의 대변에서 분리한 115주의 S. Enteritidis의 항생제 내성 및 다제내성 양상을 모니터링하였다. 그 결과, 가장 내성율이 높은 항생제는 nalidixic acid (54.8%)이었고, ampicillin (40.0%), ticarcillin (38.3%), chloramphenicol (20.9%), tetracycline (17.4%) 순이었다. 분리균의 91.3%는 1제 이상의 항생제에 내성이 있었다. 항생제 내성 유형을 살펴본 결과 nalidixic acid 단일 내성이 44.3%로 가장 높았으며, ampicillin-chloramphenicol-ticarcillin (11.3%) 및 ampicillin-ticarcillin (10.4%) 순이었다. 전체적으로 1제 내성이 51.9%, 2제 내성 18.2%, 3제 내성 14.5%, 4제 내성 5.8% 그리고 5제 이상 내성은 9.7%이었다.

Keywords

References

  1. 박석기, 박성규, 정지헌, 진영희. 2002. 서울시내 설사환자에서 분리한 살모넬라의항생제 감수성의 년도별 변화 추이. 한국식품위생안전성학회지 17, 61-70
  2. 박석기, 김무상, 이영기. 2006. 최근 5년간 서울시내 식중독 환자에서 분리한 Salmonella enterica serovar Enteritidis의 항생제 감수성 및 다제 내성 특성. 한국식품위생안정성학회지 21, 23-30
  3. 질병관리본부. 2005. 감염병실험실진단 질환별시험법 1
  4. 질병관리본부. 2005. 설사질환 실험실감시사업 연차 실적 발표 자료
  5. 질병관리본부. 2007. 살모넬라균의 혈청형
  6. 항생제의 길잡이. 2008. 대한감염학회. 고려의학
  7. Bruinsma, N., E. Stobberingh, and V. Bogaard. 2003. Antibiotic use and the prevalence of antibiotic resistance in bacteria from healthy volunteers in the Dutch community. Infection 31, 9-14 https://doi.org/10.1007/s15010-002-3035-8
  8. Clinical and Laboratory Standards Institute. 2003. Performance Standards for antimicrobial disk susceptibility tests, approved standard-8th ed, M2-A8
  9. Clinical and Laboratory Standards Institute. 2005. Performance Standards for antimicrobial disk susceptibility testing, fifteenth informational supplement, M100-S15
  10. Erdem, B., S. Ercis, G. Hascelik, D. Gur, S. Gedikoglu, A.D. Aysev, B. Sumerkan, M. Tatman-Otkun, and I. Tuncer. 2005. Antimicrobial resistance patterns and serotype distribution among Salmonella enterica strains in Turkey, 2000-2002. Eur. J. Microbiol. Infect. Dis. 24, 220-225 https://doi.org/10.1007/s10096-005-1293-y
  11. Friedland, I., L. Stinson, M. lkaiddi, S. Harm, and G.L. Woods. 2003. Resistance in Enterobacteriaceae: results of a multicenter surveillance study, 1995-2000. Infect. Control. Hosp. Epidemiol. 24, 607-612 https://doi.org/10.1086/502252
  12. Guillemot, D. 2001. How to evaluate and predicted epidemiologic impact of antibiotic use in humans: the pharmacoepidemiologic approach. Clin. Microbiol. Infect. 7, 19-23 https://doi.org/10.1046/j.1469-0691.2001.00069.x
  13. Gupta, A., N.K. Swarnkar, and S.P. Choudhary. 2001. Changing antibiotic sensitivity in enteric fever. J. Trop. Pediatr. 47, 369-371 https://doi.org/10.1093/tropej/47.6.369
  14. Hakanen, A., P. Kotilainen, P. Huovinene, H. Helenius, and A. Siitone. 2001. Reduced fluoroquinolone susceptibility in Salmonella enterica serotypes in travelers returning from Southeast Asia. Emerg. Infect. Dis. 7, 996-1003 https://doi.org/10.3201/eid0706.010613
  15. Isenbarger, D.W., C.W. Hoge, A. Srijan, C. Pitarangsi, N. Vithayasai, L. Bodhidatta, K.W. Hichey, and P.D. Cam. 2002. Comparative antibiotic resistance of diarrheal pathogens from Vietnam and Thailand, 1996-1999. Emerg. Infect. Dis. 8, 175-180 https://doi.org/10.3201/eid0802.010145
  16. Johnson, D.R., M.A. Love-Dixon, W.J. Brown, D.P. Levine, F.P. Downes, and W.N. Hall. 1992. Delayed detection of an increase in resistant Acinetobacter baumannii at a Detroit hospital. Infect. Control. Hosp. Epidemiol. 13, 394-398 https://doi.org/10.1086/646556
  17. Levy, S.B. 2002. Factors impacting on the problems of antibiotic resistance. 2002. J. Antimicrob. Chemother. 49, 25-30 https://doi.org/10.1093/jac/49.1.25
  18. Mellon, N., C. Benbrook, and K. Benbrook. 1995. Enterococcus faecium strains with van A-mediated high-level glycopeptide resistance isolated from animal foodstuffs and fecal samples of humans in the community. Microb. Drug Resist. 1, 265-272 https://doi.org/10.1089/mdr.1995.1.265
  19. Meyer, K.S., C. Urban, J.A. Eagan, B.J. Berger, and J.J. Rahal. 1993. Nosocomial outbreak of Klebsiela spp. infection resistant to late-generation cephalosporins. Ann. Intern. Med. 119, 353-358 https://doi.org/10.7326/0003-4819-119-5-199309010-00001
  20. Randall, L.P., S.W. Colles, M.K. Osborn, L.J. Piddock, and M.J. Woodwar. 2004. Antibiotic resistance genes, integrons and multiple antibiotic resistance gene in thirty-five serotypes on Salmonella enterica isolated from humans and animals in the UK. J. Antimicrob. Chemother. 53, 208-216 https://doi.org/10.1093/jac/dkh070
  21. Richet, H.M., J. Mohammed, L.C. McDonald, and W.R. Jarvis. 2001. Building communication networks: International network for the study and prevention of emerging antimicrobial resistance. Emerg. Infect. Dis. 7, 319-322 https://doi.org/10.3201/eid0702.010235
  22. Sorensen, T.L. and D. Monnet. 2000. Control of antibiotic use in the community: the Danish experience. Infect. Control Hosp. Epidemiol. 21, 387-389 https://doi.org/10.1086/501778
  23. Threlfall, E.J. and L.R. Ward. 2001. Decreased susceptibility to ciprofloxacin in Salmonella enterica serotype Typhi in the United Kingdom. Emerg. Infect. Dis. 7, 448-450 https://doi.org/10.3201/eid0703.017315
  24. van Den Bogaard, A.E., N. London, and E.E. Stobberingh. 2000. Antimicrobial resistance in pig faecal samples from the Netherlands and Sweden. J. Antimicrob. Chemother. 45, 663-671 https://doi.org/10.1093/jac/45.5.663
  25. Ward, L.R., E.J. Threlfall, and B. Rowe. 1990. Multiple drug resistance in salmonella in England and Wales: a comparison between 1981 and 1988. J. Clin. Pathol. 43, 563-566 https://doi.org/10.1136/jcp.43.7.563
  26. Willems, R.J., J. Top, N. Braak, A. Belkum, and J.D. Endtz. 2000. Host specifity of vancomycin-resistance Enterococcus faecium. J. Infect. Dis. 182, 816-823 https://doi.org/10.1086/315752