Antimicrobial Resistance and Multidrug Resistance Patterns of Salmonella enterica serovar Enteritidis Isolated from Diarrhea Patients, Incheon

인천지역 설사환자에서 분리한 Salmonella enterica serovar Enteritidis의 항생제 내성 및 다제내성 양상

  • 황경화 (인천광역시보건환경연구원 질병조사과) ;
  • 오보영 (인천광역시보건환경연구원 질병조사과) ;
  • 김정희 (인천광역시보건환경연구원 질병조사과) ;
  • 김명희 (인천광역시보건환경연구원 질병조사과) ;
  • 제갈승 (인천광역시보건환경연구원 질병조사과) ;
  • 이은주 (인천광역시보건환경연구원 질병조사과) ;
  • 이은정 (인천광역시보건환경연구원 질병조사과) ;
  • 조남규 (인천광역시보건환경연구원 질병조사과) ;
  • 고종명 (인천광역시보건환경연구원 질병조사과) ;
  • 김용희 (인천광역시보건환경연구원 질병조사과)
  • Received : 2009.04.27
  • Accepted : 2009.06.08
  • Published : 2009.06.30

Abstract

This study describes the antimicrobial susceptibility and multidrug resistance patterns in 115 isolates of Salmonella enterica serovar Enteritidis from diarrhea patients in Incheon from Jan. 2004 to Dec. 2008. Overall, the highest rate of resistance was found to the following antimicrobial agents: nalidixic acid 54.8%, ampicillin 40.0%, ticarcillin 38.3%, chloramphenicol 20.9%, and tetracycline 17.4%. 91% (104 isolates) were resistant to one or more antimicrobial agents tested. Among the described antimicrobial resistant patterns, the predominant patterns were only nalidixic acid (44.3%), ampicillin-chloramphenicol-ticarcillin (11.3%,) and ampicillin-ticarcillin (10.4%). Overall, the resistant rate to one drug was 51.9%, two drugs 18.2%, three drugs 14.5%, four drugs 5.8%, and five or more drugs 9.7%.

본 연구에서는 2004년 1월부터 2008년 12월까지 인천지역 5개 종합 병 의원에 설사증상으로 입원 또는 내원한 환자의 대변에서 분리한 115주의 S. Enteritidis의 항생제 내성 및 다제내성 양상을 모니터링하였다. 그 결과, 가장 내성율이 높은 항생제는 nalidixic acid (54.8%)이었고, ampicillin (40.0%), ticarcillin (38.3%), chloramphenicol (20.9%), tetracycline (17.4%) 순이었다. 분리균의 91.3%는 1제 이상의 항생제에 내성이 있었다. 항생제 내성 유형을 살펴본 결과 nalidixic acid 단일 내성이 44.3%로 가장 높았으며, ampicillin-chloramphenicol-ticarcillin (11.3%) 및 ampicillin-ticarcillin (10.4%) 순이었다. 전체적으로 1제 내성이 51.9%, 2제 내성 18.2%, 3제 내성 14.5%, 4제 내성 5.8% 그리고 5제 이상 내성은 9.7%이었다.

Keywords

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