Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

USE OF CORTICOSTEROIDS IN THE TREATMENT OF LOCALIZED LANGERHANS CELL HISTIOCYTOSIS OF THE MANDIBLE : CASE REPORT

Corticosteroid를 이용한 하악에 발현된 Langerhans Cell Histiocytosis의 치료 : 증례보고

  • Choi, Jung-Yong (Department of Oral Maxillofacial Surgery. St. Mary's Hospital. The Catholic University of Korea) ;
  • Lee, Sang-Hwa (Department of Oral Maxillofacial Surgery. St. Mary's Hospital. The Catholic University of Korea) ;
  • Yoon, Hyun-Joong (Department of Oral Maxillofacial Surgery. St. Mary's Hospital. The Catholic University of Korea)
  • 최정용 (가톨릭대학교 의과대학 성모병원 구강악안면외과) ;
  • 이상화 (가톨릭대학교 의과대학 성모병원 구강악안면외과) ;
  • 윤현중 (가톨릭대학교 의과대학 성모병원 구강악안면외과)
  • Received : 2009.04.02
  • Accepted : 2009.05.14
  • Published : 2009.05.30
Download PDF
⟨ Previous Next ⟩

Abstract

Langerhans cell histiocytosis(LCH), previously known as histiocytosis X, is rare, proliferative disorder in which the accumulation of pathologic Langerhans cell leads to tissue infiltration and destruction. The jaw is involved 10~20% of all LCH and most common oral symptoms are jaw swelling or a palpation mass. Most of subjects are males and disease appears to start before the age of 10 years. An 11 years old girl was referred from pediatric department. Histological examination confirmed the diagnosis LCH. She was treated intra-lesional injection of corticosteroid. The overall outcome was excellent. After a follow-up period of 20 month, the patient present with no evidence of residual disease on Panoramic view and whole body bone scan. We report this early recognized LCH case treated by corticoid injection in good progress with literature review.

Keywords

References

  1. Yasko AW, Fanning CV, Ayala AG et al : Percutaneous techniques for the diagnosis and treatment of localized Langerhans-cell histiocytosis (eosinophilic granuloma of bone). J Bone Joint Surg Am 80 : 219, 1998
  2. Jones AV, Franklin CD : An analysis of oral and maxillofacial pathology found in children over a 30-year period. Int J Paediatr Dent 16 : 19, 2006 https://doi.org/10.1111/j.1365-263X.2006.00683.x
  3. Hartman KS. Histiocytosis X : a review of 114 cases with oral involvement. Oral Surg Oral Med Oral Pathol 49 : 38, 1980 https://doi.org/10.1016/0030-4220(80)90030-4
  4. Cohen M, Zornoza J, Cangir A et al : Direct injection of methylprednisolone sodium succinate in the treatment of solitary eosinophilic granuloma of bone: a report of 9 cases. Radiology 136 : 289, 1980
  5. Ardekian L, Peled M, Rosen D et al : Clinical and radiographic features of eosinophilic granuloma in the jaws: review of 41 lesions treated by surgery and low-dose radiotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87 : 238, 1999 https://doi.org/10.1016/S1079-2104(99)70279-9
  6. McClain KL, Natkunam Y, Swerdlow SH : Atypical cellular disorders. Hematology Am Soc Hematol Educ Program 283, 2004
  7. Stoll m, Freund M, Schmidt H et al : Allogeneic bone marrow transplantation for Langerhans'cell histiocytosis. Cancer 66 : 284, 1990 https://doi.org/10.1002/1097-0142(19900715)66:2<284::AID-CNCR2820660215>3.0.CO;2-O
  8. Glotzbecker MP, Carpentieri DF, Dormans JP : Langerhans cell histiocytosis: a primary viral infection of bone? Human herpes virus 6 latent protein detected in lymphocytes from tissue of children. J Pediatr Orthop 24 : 123, 2004 https://doi.org/10.1097/01241398-200401000-00022
  9. Martinez-Lage JF, Poza M, Cartagena J et al : Solitary eosinophilic granuloma of the pediatric skull and spine. The role of surgery. Childs Nerv Syst 7 : 448. 1991 https://doi.org/10.1007/BF00263187
  10. Yu Q, Wang PZ, Shi HM et al : Radiographic findings in Langerhans' cell disease affecting the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79 : 251, 1995 https://doi.org/10.1016/S1079-2104(05)80292-6
  11. Key SJ, O'Brien CJ, Silvester KC et al : Eosinophilic granuloma: resolution of maxillofacial bony lesions following minimal intervention. Report of three cases and a review of the literature. J Craniomaxillofac Surg 32 : 170, 2004 https://doi.org/10.1016/j.jcms.2004.01.004
  12. Uckan S, Gurol M, Durmus E : Recurrent multifocal Langerhans cell eosinophilic granuloma of the jaws: report of a case. J Oral Maxillofac Surg 54 : 906, 1996 https://doi.org/10.1016/S0278-2391(96)90546-7
  13. Richter MP, D'Angio GJ : The role of radiation therapy in the management of children with histiocytosis X. Am J Pediatr Hematol Oncol 3 : 161, 1981 https://doi.org/10.1097/00043426-198100320-00008
  14. khan MA, Kosugi S, Tomizawa M et al : Effects of radiotherapy on dentofacial regions at early age: case report. Pediatric Dental Journal 4 : 83, 1994
  15. Scaglietti O, Marchetti PG, Bartolozzi P : The effects of methylprednisolone acetate in the treatment of bone cysts. Results of three years follow-up. J Bone Joint Surg Br 61 : 200, 1979
  16. Jones LR, Toth BB, Cangir A. Treatment for solitary eosinophilic granuloma of the mandible by steroid injection: report of a case. J Oral Maxillofac Surg 47 : 306, 1989 https://doi.org/10.1016/0278-2391(89)90238-3
  17. Egeler RM, de Kraker J, Voute PA : Cytosine-arabinoside, vincristine, and prednisolone in the treatment of children with disseminated Langerhans cell histiocytosis with organ dysfunction: experience at a single institution. Med Pediatr Oncol 21 : 265, 1993 https://doi.org/10.1002/mpo.2950210406
  18. Egeler RM, Thompson RC Jr, Voute PA et al : Intralesional infiltration of corticosteroids in localized Langerhans'cell histiocytosis. J Pediatr Orthop 12 : 811, 1992 https://doi.org/10.1097/01241398-199211000-00021
  19. Marusic, A, Raisz L : Cortisol modulates the actions of interleukin-1 alpha on bone formation, resorption, and prostaglandin production in cultured mouse parietal bones. Endocrinology 129 : 2699, 1991 https://doi.org/10.1210/endo-129-5-2699
  20. Haupt R, Nanduri V, Calevo MG et al : Permanent consequences in Langerhans cell histiocytosis patients: a pilot study from the Histiocyte Society-Late Effects Study Group. Pediatr Blood Cancer 42 : 438, 2004 https://doi.org/10.1002/pbc.20021